Gatifloxacin hydrochloride - CAS 121577-32-0
Catalog number:
121577-32-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H23ClFN3O4
Molecular Weight:
411.86
COA:
Inquire
Targets:
Antibacterial
Description:
Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Gatifloxacin hydrochloride
MSDS:
Inquire
1.Synergistic combination dry powders for inhaled antimicrobial therapy: formulation, characterization and in vitro evaluation.
Lee SH1, Teo J2, Heng D3, Ng WK1, Chan HK4, Tan RB5. Eur J Pharm Biopharm. 2013 Feb;83(2):275-84. doi: 10.1016/j.ejpb.2012.09.002. Epub 2012 Sep 23.
In combination antimicrobial therapy, the desired outcome is to broaden the antimicrobial spectrum and to achieve a possible synergistic effect. However, adverse antagonistic species may also emerge from such combinations, leading to treatment failure with serious consequences. It is therefore imperative to screen the drug candidates for compatibility and possible antagonistic interactions. The aim of this work was to develop a novel synergistic dry powder inhaler (DPI) formulation for antimicrobial combination therapy via the pulmonary route. Binary (ciprofloxacin hydrochloride and gatifloxacin hydrochloride, SD-CIP/GAT) and ternary (ciprofloxacin hydrochloride, gatifloxacin hydrochloride, and lysozyme, SD-CIP/GAT/LYS) combinations were prepared via spray-drying on a BUCHI® Nano Spray Dryer B-90. The powder morphologies were spherical with a slightly corrugated surface and all within the respirable size range. The powders yielded fine particle fractions (of the loaded dose) of over 40% when dispersed using an Aerolizer® at 60 L/min.
2.Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas.
Sharma N1, Samal A, Sharma R, Tandon R, Titiyal JS, Satpathy G, Sen S, Vajpayee RB. Eye Contact Lens. 2012 Sep;38(5):295-9.
PURPOSE: To evaluate demographic, clinical, and microbiological profile of eye donors and efficacy of 0.3% gatifloxacin hydrochloride in microbial decontamination of donor corneas.
3.Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.
Arthanari S1, Mani G, Jang JH, Choi JO, Cho YH, Lee JH, Cha SE, Oh HS, Kwon DH, Jang HT. Artif Cells Nanomed Biotechnol. 2014 Dec 15:1-6. [Epub ahead of print]
The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds.
4.Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.
Pawar MD1, Rathna GV2, Agrawal S3, Kuchekar BS4. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:126-37. doi: 10.1016/j.msec.2014.11.037. Epub 2014 Nov 12.
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (Tg) of PNIPAM. Similarly Tg and melting temperature (Tm) of PCL were shifted.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 130-16-5 Cloxiquine

Cloxiquine
(CAS: 130-16-5)

Cloxiquine, a quinoline derivative, could be commonly used as anti-infective and antioxidant agent.

CAS 168828-58-8 Sutezolid

Sutezolid
(CAS: 168828-58-8)

Sutezolid, also called as PNU-100480, is an oxazolidinone antibacterial compound to reach Phase-II clinical research for Tuberculosis.

CAS 78110-38-0 Aztreonam

Aztreonam
(CAS: 78110-38-0)

Aztreonam inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-bin...

CAS 54-85-3 Isoniazid

Isoniazid
(CAS: 54-85-3)

Isoniazid is a prodrug and must be activated by bacterial catalase.

CAS 96036-03-2 Meropenem

Meropenem
(CAS: 96036-03-2)

Meropenem is bactericidal except against Listeria monocytogenes, where it is bacteriostatic. It inhibits bacterial wall synthesis like other β-lactam antibiotic...

CAS 165800-04-4 Eperezolid

Eperezolid
(CAS: 165800-04-4)

Eperezolid(PNU-100592) is a oxazolidinone antibacterial agent, Eperezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibili...

CAS 9001-63-2 Lysozyme

Lysozyme
(CAS: 9001-63-2)

Lysozyme is an antimicrobial enzyme produced by animals, damaging bacterial cell walls via hydrolysis between residues in peptidoglycan walls.

CAS 123171-59-5 Cefepime Dihydrochloride Monohydrate

Cefepime Dihydrochloride Monohydrate
(CAS: 123171-59-5)

Cefepime is an extended-spectrum parenteral cephalosporin antibiotic active in vitro against a broad spectrum of gram-positive and gram-negative aerobic bacteri...

CAS 1404-90-6 Vancomycin

Vancomycin
(CAS: 1404-90-6)

Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.

CAS 113617-63-3 Orbifloxacin

Orbifloxacin
(CAS: 113617-63-3)

Orbifloxacin is a third generation of fluoroquinolone that exhibits increased antibacterial activity against the Enterobacteriaceae, gram-negative and gram-posi...

CAS 179033-51-3 Timcodar

Timcodar
(CAS: 179033-51-3)

Timcodar, a pyridine derivative, has been found to be a p-glycoprotein inhibitor as well as nerve growth factor stimulant and was once studied in the treatment ...

CAS 74610-55-2 Tylosin tartrate

Tylosin tartrate
(CAS: 74610-55-2)

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.

CAS 64-72-2 Chlortetracycline HCl

Chlortetracycline HCl
(CAS: 64-72-2)

Chlortetracycline HCl is the first identified tetracycline antibiotic.

CAS 1476-53-5 Novobiocin Sodium

Novobiocin Sodium
(CAS: 1476-53-5)

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and ...

CAS 229016-73-3 Ceftaroline fosamil

Ceftaroline fosamil
(CAS: 229016-73-3)

Ceftaroline fosamil, a cephalosporin antibiotic, is active against methicillin-resistant Staphylococcus aureus (MRSA) and Gram-positive bacteria.

CAS 1695-77-8 Spectinomycin

Spectinomycin
(CAS: 1695-77-8)

Spectinomycin, a derivative of streptomyces spectabilis, has been found to be effective against gram-negative bacteria.

CAS 55-56-1 Chlorhexidine

Chlorhexidine
(CAS: 55-56-1)

Chlorhexidine is a disinfectant and topical anti-infective agent for reduction of pocket depth in patients with adult periodontitis.

CAS 74849-93-7 Cefpiramide sodium

Cefpiramide sodium
(CAS: 74849-93-7)

Cefpiramide sodium is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity. It was more active against Acinetobacter spp. and ...

CAS 32887-03-9 Pivmecillinam hydrochloride

Pivmecillinam hydrochloride
(CAS: 32887-03-9)

Pivmecillinam hydrochloride is the hydrochloride salt of Pivmecillinam, which is the pivoxil ester form of penicillin and active against gram-negative organisms...

CAS 50370-12-2 Cefadroxil

Cefadroxil
(CAS: 50370-12-2)

Cefadroxilis a broad-spectrum antibiotic of the cephalosporin type as a first-generation cephalosporin antibiotic used to treat urinary tract infections

Chemical Structure

CAS 121577-32-0 Gatifloxacin hydrochloride

Quick Inquiry

Verification code

Featured Items