Gatifloxacin hydrochloride - CAS 121577-32-0
Catalog number: 121577-32-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H23ClFN3O4
Molecular Weight:
411.86
COA:
Inquire
Targets:
Antibacterial
Description:
Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Gatifloxacin hydrochloride
MSDS:
Inquire
1.Synergistic combination dry powders for inhaled antimicrobial therapy: formulation, characterization and in vitro evaluation.
Lee SH1, Teo J2, Heng D3, Ng WK1, Chan HK4, Tan RB5. Eur J Pharm Biopharm. 2013 Feb;83(2):275-84. doi: 10.1016/j.ejpb.2012.09.002. Epub 2012 Sep 23.
In combination antimicrobial therapy, the desired outcome is to broaden the antimicrobial spectrum and to achieve a possible synergistic effect. However, adverse antagonistic species may also emerge from such combinations, leading to treatment failure with serious consequences. It is therefore imperative to screen the drug candidates for compatibility and possible antagonistic interactions. The aim of this work was to develop a novel synergistic dry powder inhaler (DPI) formulation for antimicrobial combination therapy via the pulmonary route. Binary (ciprofloxacin hydrochloride and gatifloxacin hydrochloride, SD-CIP/GAT) and ternary (ciprofloxacin hydrochloride, gatifloxacin hydrochloride, and lysozyme, SD-CIP/GAT/LYS) combinations were prepared via spray-drying on a BUCHI® Nano Spray Dryer B-90. The powder morphologies were spherical with a slightly corrugated surface and all within the respirable size range. The powders yielded fine particle fractions (of the loaded dose) of over 40% when dispersed using an Aerolizer® at 60 L/min.
2.Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas.
Sharma N1, Samal A, Sharma R, Tandon R, Titiyal JS, Satpathy G, Sen S, Vajpayee RB. Eye Contact Lens. 2012 Sep;38(5):295-9.
PURPOSE: To evaluate demographic, clinical, and microbiological profile of eye donors and efficacy of 0.3% gatifloxacin hydrochloride in microbial decontamination of donor corneas.
3.Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.
Arthanari S1, Mani G, Jang JH, Choi JO, Cho YH, Lee JH, Cha SE, Oh HS, Kwon DH, Jang HT. Artif Cells Nanomed Biotechnol. 2014 Dec 15:1-6. [Epub ahead of print]
The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds.
4.Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.
Pawar MD1, Rathna GV2, Agrawal S3, Kuchekar BS4. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:126-37. doi: 10.1016/j.msec.2014.11.037. Epub 2014 Nov 12.
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (Tg) of PNIPAM. Similarly Tg and melting temperature (Tm) of PCL were shifted.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


Antibiotic-202
(CAS: 1616113-45-1)

Antibiotic-202 has antibacterial property.

ABT-255
(CAS: 186293-38-9)

ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative ...

CAS 59-87-0 Nitrofural

Nitrofural
(CAS: 59-87-0)

Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

CAS 127-79-7 Sulfamerazine

Sulfamerazine
(CAS: 127-79-7)

Sulfamerazine is a sulfonamide antibacterial.

CAS 68401-82-1 Ceftizoxime sodium

Ceftizoxime sodium
(CAS: 68401-82-1)

A semisynthetic cephalosporin antibiotic for the treatment of infections due to susceptible strains of microorganisms.

CAS 141702-36-5 Faropenem daloxate

Faropenem daloxate
(CAS: 141702-36-5)

Faropenem daloxate is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influe...

CAS 163680-77-1 Pazufloxaxin methanesulfonate

Pazufloxaxin methanesulfonate
(CAS: 163680-77-1)

Pazufloxaxin methanesulfonate is a fluoroquinolone broad-spectrum antibacterial which potent actions against both gram-positive and gram-negative bacteria.

CAS 32887-01-7 Mecillinam

Mecillinam
(CAS: 32887-01-7)

Mecillinam is an extended-spectrum penicillin antibiotic as an active antibacterial against gram-negative bacteria.

CAS 111696-23-2 Cefetamet Pivoxil Hydrochloride

Cefetamet Pivoxil Hydrochloride
(CAS: 111696-23-2)

The hydrochloride salt form of Cefetamet pivoxil, one of the third generation cephalosporin antibiotics, could be effective in the treatment for sorts of infect...

CAS 69-53-4 Ampicillin

Ampicillin
(CAS: 69-53-4)

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family and is roughly equivalent to its successor, amoxicillin in terms of spectrum a...

CAS 127-58-2 Sulfamerazine sodium salt

Sulfamerazine sodium salt
(CAS: 127-58-2)

Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial syn...

CAS 96036-03-2 Meropenem

Meropenem
(CAS: 96036-03-2)

Meropenem is bactericidal except against Listeria monocytogenes, where it is bacteriostatic. It inhibits bacterial wall synthesis like other β-lactam antibiotic...

CAS 18472-51-0 Chlorhexidine digluconate

Chlorhexidine digluconate
(CAS: 18472-51-0)

Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation stu...

CAS 61036-62-2 Teicoplanin

Teicoplanin
(CAS: 61036-62-2)

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections. Teicoplanin is a semisynthetic glycopeptide antibiotic with a spectrum...

CAS 165800-04-4 Eperezolid

Eperezolid
(CAS: 165800-04-4)

Eperezolid(PNU-100592) is a oxazolidinone antibacterial agent, Eperezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibili...

CAS 1071638-38-4 MAC13243

MAC13243
(CAS: 1071638-38-4)

MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA.

CAS 113359-04-9 Cefozopran

Cefozopran
(CAS: 113359-04-9)

Cefozopran is a fourth-generation cephalosporin.

CAS 57-67-0 Sulfaguanidine

Sulfaguanidine
(CAS: 57-67-0)

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

CAS 120410-24-4 Biapenem

Biapenem
(CAS: 120410-24-4)

Biapenem (INN) is a carbapenem antibiotic. It has in vitro activity against anaerobes.

CAS 57-68-1 Sulfamethazine

Sulfamethazine
(CAS: 57-68-1)

Sulfadimidine or sulfamethazine is a sulfonamide antibacterial.

Chemical Structure

CAS 121577-32-0 Gatifloxacin hydrochloride

Quick Inquiry

Verification code

Featured Items