Gatifloxacin hydrochloride - CAS 121577-32-0
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Not Intended for Therapeutic Use. For research use only.
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Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
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Gatifloxacin hydrochloride
1.Synergistic combination dry powders for inhaled antimicrobial therapy: formulation, characterization and in vitro evaluation.
Lee SH1, Teo J2, Heng D3, Ng WK1, Chan HK4, Tan RB5. Eur J Pharm Biopharm. 2013 Feb;83(2):275-84. doi: 10.1016/j.ejpb.2012.09.002. Epub 2012 Sep 23.
In combination antimicrobial therapy, the desired outcome is to broaden the antimicrobial spectrum and to achieve a possible synergistic effect. However, adverse antagonistic species may also emerge from such combinations, leading to treatment failure with serious consequences. It is therefore imperative to screen the drug candidates for compatibility and possible antagonistic interactions. The aim of this work was to develop a novel synergistic dry powder inhaler (DPI) formulation for antimicrobial combination therapy via the pulmonary route. Binary (ciprofloxacin hydrochloride and gatifloxacin hydrochloride, SD-CIP/GAT) and ternary (ciprofloxacin hydrochloride, gatifloxacin hydrochloride, and lysozyme, SD-CIP/GAT/LYS) combinations were prepared via spray-drying on a BUCHI® Nano Spray Dryer B-90. The powder morphologies were spherical with a slightly corrugated surface and all within the respirable size range. The powders yielded fine particle fractions (of the loaded dose) of over 40% when dispersed using an Aerolizer® at 60 L/min.
2.Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas.
Sharma N1, Samal A, Sharma R, Tandon R, Titiyal JS, Satpathy G, Sen S, Vajpayee RB. Eye Contact Lens. 2012 Sep;38(5):295-9.
PURPOSE: To evaluate demographic, clinical, and microbiological profile of eye donors and efficacy of 0.3% gatifloxacin hydrochloride in microbial decontamination of donor corneas.
3.Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.
Arthanari S1, Mani G, Jang JH, Choi JO, Cho YH, Lee JH, Cha SE, Oh HS, Kwon DH, Jang HT. Artif Cells Nanomed Biotechnol. 2014 Dec 15:1-6. [Epub ahead of print]
The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds.
4.Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.
Pawar MD1, Rathna GV2, Agrawal S3, Kuchekar BS4. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:126-37. doi: 10.1016/j.msec.2014.11.037. Epub 2014 Nov 12.
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (Tg) of PNIPAM. Similarly Tg and melting temperature (Tm) of PCL were shifted.
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CAS 121577-32-0 Gatifloxacin hydrochloride

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