Gatifloxacin hydrochloride - CAS 121577-32-0
Catalog number: 121577-32-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H23ClFN3O4
Molecular Weight:
411.86
COA:
Inquire
Targets:
Antibacterial
Description:
Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Gatifloxacin hydrochloride
MSDS:
Inquire
1.Synergistic combination dry powders for inhaled antimicrobial therapy: formulation, characterization and in vitro evaluation.
Lee SH1, Teo J2, Heng D3, Ng WK1, Chan HK4, Tan RB5. Eur J Pharm Biopharm. 2013 Feb;83(2):275-84. doi: 10.1016/j.ejpb.2012.09.002. Epub 2012 Sep 23.
In combination antimicrobial therapy, the desired outcome is to broaden the antimicrobial spectrum and to achieve a possible synergistic effect. However, adverse antagonistic species may also emerge from such combinations, leading to treatment failure with serious consequences. It is therefore imperative to screen the drug candidates for compatibility and possible antagonistic interactions. The aim of this work was to develop a novel synergistic dry powder inhaler (DPI) formulation for antimicrobial combination therapy via the pulmonary route. Binary (ciprofloxacin hydrochloride and gatifloxacin hydrochloride, SD-CIP/GAT) and ternary (ciprofloxacin hydrochloride, gatifloxacin hydrochloride, and lysozyme, SD-CIP/GAT/LYS) combinations were prepared via spray-drying on a BUCHI® Nano Spray Dryer B-90. The powder morphologies were spherical with a slightly corrugated surface and all within the respirable size range. The powders yielded fine particle fractions (of the loaded dose) of over 40% when dispersed using an Aerolizer® at 60 L/min.
2.Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas.
Sharma N1, Samal A, Sharma R, Tandon R, Titiyal JS, Satpathy G, Sen S, Vajpayee RB. Eye Contact Lens. 2012 Sep;38(5):295-9.
PURPOSE: To evaluate demographic, clinical, and microbiological profile of eye donors and efficacy of 0.3% gatifloxacin hydrochloride in microbial decontamination of donor corneas.
3.Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.
Arthanari S1, Mani G, Jang JH, Choi JO, Cho YH, Lee JH, Cha SE, Oh HS, Kwon DH, Jang HT. Artif Cells Nanomed Biotechnol. 2014 Dec 15:1-6. [Epub ahead of print]
The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds.
4.Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.
Pawar MD1, Rathna GV2, Agrawal S3, Kuchekar BS4. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:126-37. doi: 10.1016/j.msec.2014.11.037. Epub 2014 Nov 12.
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared. Non-woven nanofibers of various compositions were fabricated using an electrospinning technique. The morphology of the nanofibers was analyzed by an environmental scanning electron microscope. The morphology was influenced by the concentration of polymer, drug, and polymer blend composition. Fourier transform infrared spectroscopy analysis showed the shift in bands due to hydrogen ion interactions between polymers and drug. Thermogram of PNIPAM/PCL/EA with Gati recorded a shift in lower critical solution temperature (LCST) and glass transition temperature (Tg) of PNIPAM. Similarly Tg and melting temperature (Tm) of PCL were shifted.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 1257426-19-9 TBA-354

TBA-354
(CAS: 1257426-19-9)

TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamani...

CAS 58-71-9 Cephalothin sodium

Cephalothin sodium
(CAS: 58-71-9)

Cephalothin sodium is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally used to pr...

CAS 69-52-3 Ampicillin sodium

Ampicillin sodium
(CAS: 69-52-3)

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

CAS 127045-41-4 Pazufloxacin

Pazufloxacin
(CAS: 127045-41-4)

Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmona...

CAS 32887-01-7 Mecillinam

Mecillinam
(CAS: 32887-01-7)

Mecillinam is an extended-spectrum penicillin antibiotic as an active antibacterial against gram-negative bacteria.

CAS 34642-77-8 Amoxicillin Sodium

Amoxicillin Sodium
(CAS: 34642-77-8)

Amoxicillin Sodium is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.

CAS 74578-69-1 Ceftriaxone Sodium

Ceftriaxone Sodium
(CAS: 74578-69-1)

Ceftriaxone Sodium is an antibiotic, a third-generation cephalosporin. It has broad-spectrum activity against Gram-positive bacteria and expanded Gram-negative ...

CAS 127-58-2 Sulfamerazine sodium salt

Sulfamerazine sodium salt
(CAS: 127-58-2)

Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial syn...

CAS 87450-64-4 ATH-18534

ATH-18534
(CAS: 87450-64-4)

ATH-18534 is an antibacterial agent.

CAS 4697-14-7 Ticarcillin disodium

Ticarcillin disodium
(CAS: 4697-14-7)

Ticarcillin disodium a carboxypenicillin used to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cel...

CAS 113-98-4 Penicillin G potassium

Penicillin G potassium
(CAS: 113-98-4)

Penicillin G potassium is a fast-acting antibiotic, used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas.

CAS 98079-51-7 Lomefloxacin

Lomefloxacin
(CAS: 98079-51-7)

Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms, which is commonly used to ...

CAS 57-67-0 Sulfaguanidine

Sulfaguanidine
(CAS: 57-67-0)

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

CAS 56796-39-5 Cefmetazole Sodium

Cefmetazole Sodium
(CAS: 56796-39-5)

Cefmetazole Sodium , contains an N-methylthiotetrazole side chain, is a semisynthetic cephamycin antibiotic with a broad spectrum of activity as a second-genera...

CAS 120410-24-4 Biapenem

Biapenem
(CAS: 120410-24-4)

Biapenem (INN) is a carbapenem antibiotic. It has in vitro activity against anaerobes.

CAS 1192500-31-4 Avibactam free acid

Avibactam free acid
(CAS: 1192500-31-4)

Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftaroline in the U....

CAS 26605-69-6 Sodium Indanylcarbinicillin

Sodium Indanylcarbinicillin
(CAS: 26605-69-6)

Sodium Indanylcarbinicillin, a penicillin-derived, has been used as a β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the...

CAS 14769-73-4 Levamisole

Levamisole
(CAS: 14769-73-4)

Levamisole, a thiazole derivative, has been found to be an antibiotic used to against parasitic worm infections and could also have potential activity in antica...

CAS 84294-96-2 Enoxacin hydrate

Enoxacin hydrate
(CAS: 84294-96-2)

Enoxacin hydrate is a synthetic antibiotic belonging to quinolone carboxylic acid compound. It is bactericidal and has a postantibiotischen effect. It is a broa...

CAS 13009-99-9 Mafenide Acetate

Mafenide Acetate
(CAS: 13009-99-9)

Mafenide is a bacteriostatic antibiotic with a broad activity against Gram positive, Gram negative bacteria and Clostridia. Mafenide acetate penetrates eschar a...

Chemical Structure

CAS 121577-32-0 Gatifloxacin hydrochloride

Quick Inquiry

Verification code

Featured Items