Gatifloxacin - CAS 112811-59-3
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
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AM-1155, CG5501, BMS-206584
1.A Surveillance Bacteriological Study of Acute Bacterial Rhinosinusitis in Thailand and the Clinical Responses to the Culture-directed Antibiotics.
Thanaviratananich S, Chusakul S, Moungthong G, Luxameechanporn T, Tantilipikorn P, Fooanant S, Aeumjaturapat S, Sribenjalux P, Makachen N, Chainansamit S, Chaiyasate S, Bunnag C. J Med Assoc Thai. 2015 Aug;98 Suppl 7:S204-16.
OBJECTIVE: To examine: 1) types of bacteria and antimicrobial sensitivity of commonly used antibiotics for acute bacterial rhinosinusitis (ABRS) in Thailand, 2) the effectiveness of using antibiotics according to antimicrobial sensitivity, and 3) the effectiveness of using antibiotics according to the Thai clinical practice guidelines (CPG) of ABRS.
2.A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.
Pham Thanh D1, Karkey A2, Dongol S2, Ho Thi N1, Thompson CN1,3,4, Rabaa MA1,3, Arjyal A2, Holt KE5, Wong V6, Tran Vu Thieu N1, Voong Vinh P1, Ha Thanh T1, Pradhan A7, Shrestha SK7, Gajurel D7, Pickard D6, Parry CM4,8, Dougan G6, Wolbers M1,3, Dolecek C1,3 Elife. 2016 Mar 11;5. pii: e14003. doi: 10.7554/eLife.14003.
The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S. Typhi isolates were genome sequenced and clinical observations, treatment failures and fever clearance times (FCTs) were stratified by lineage. Most fluoroquinolone-resistant S. Typhi belonged to a specific H58 subclade. Treatment failure with S. Typhi-H58 was significantly less frequent with ceftriaxone (3/31; 9.7%) than gatifloxacin (15/34; 44.1%)(Hazard Ratio 0.19, p=0.002). Further, for gatifloxacin-treated patients, those infected with fluoroquinolone-resistant organisms had significantly higher median FCTs (8.2 days) than those infected with susceptible (2.96) or intermediately resistant organisms (4.01)(pS. Typhi clade internationally, but there are no data regarding disease outcome with this organism.
3.Prevalence and Characterization of Cronobacter sakazakii in Retail Milk-Based Infant and Baby Foods in Shaanxi, China.
Li Z1, Ge W1, Li K1, Gan J1, Zhang Y2, Zhang Q1, Luo R3, Chen L4, Liang Y1, Wang Q1, Xi M1, Xia X1, Wang X1, Yang B1. Foodborne Pathog Dis. 2016 Apr;13(4):221-7. doi: 10.1089/fpd.2015.2074. Epub 2016 Feb 17.
Cronobacter sakazakii (formerly Enterobacter sakazakii) is an opportunistic pathogen that causes meningitis, sepsis, and necrotizing enterocolitis in neonates and infants through consumption of contaminated milk-based foods. In this study, the prevalence of C. sakazakii in 705 retail milk-based infant and baby food samples was investigated in 12 cities in Shaanxi, China, in 2010 and 2012. One hundred and nineteen samples (16.9%) were C. sakazakii positive. The isolates were further characterized for antimicrobial susceptibility to 14 antibiotics, pulsed-field gel electrophoresis profiles, and presence of the virulence genes. Samples of brand W, Y, A, and G in 2010 and 2012 were C. sakazakii positive. All isolates recovered in 2010 and 2012 were susceptible to levofloxacin and cefoperazone. In 2012, no isolate was resistant to gentamicin, cefoxitin, chloramphenicol, gatifloxacin, ciprofloxacin, and ceftriaxone. Antibiotic resistance of the isolates was most commonly found to rifampicin, amoxicillin-clavulanic acid, streptomycin, tetracycline, and ampicillin in both 2010 and 2012, except to trimethoprim/sulfamethoxazole in 2012.
4.Characterization of melt-quenched and milled amorphous solids of gatifloxacin.
Hattori Y1, Suzuki A1, Otsuka M1. Drug Dev Ind Pharm. 2016 Apr 24:1-20. [Epub ahead of print]
The objectives of this study were to characterize and investigate the differences in amorphous states of gatifloxacin. We prepared two types of gatifloxacin amorphous solids coded as M and MQ using milling and melt-quenching methods, respectively. The amorphous solids were characterized via x-ray diffraction (XRD), non-isothermal differential scanning calorimetry (DSC), and time-resolved near-infrared (NIR) spectroscopy. Both solids displayed halo XRD patterns characteristic of amorphous solids; however, in the non-isothermal DSC profiles, these amorphous solids were distinguished by their crystallization and melting temperatures. The Kissinger-Akahira-Sunose plots of non-isothermal crystallization temperatures at various heating rates indicated a lower activation energy of crystallization for the amorphous solid M than that of MQ. These results support the differentiation between two amorphous states with different physical and chemical properties.
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CAS 112811-59-3 Gatifloxacin

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