Garjasmin - CAS 144868-43-9
Catalog number: 144868-43-9
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H12O5
Molecular Weight:
224.2
COA:
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Chemical Family:
Iridoids
Description:
Garjasmin is a natural iridoid found in the herbs of Nauclea officinalis.
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Purity:
>98%
Appearance:
Powder
Synonyms:
(2aS,4aS,7aS,7bS)-2a,4a,7a,7b-Tetrahydro-2a-hydroxy-2H-1,7-dioxacyclopent[cd]indene-5-carboxylic acid methyl ester
MSDS:
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Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Two new bioactive iridoids from Rothmannia wittii.
Chaipukdee N;Kanokmedhakul K;Kanokmedhakul S;Lekphrom R;Pyne SG Fitoterapia. 2016 Sep;113:97-101. doi: 10.1016/j.fitote.2016.07.007. Epub 2016 Jul 16.
The first reported study of the isolation and identification of compounds from the bark and fruit of Rothmannia wittii yielded two new iridoids, 6β-hydroxy-10-O-acetylgenipin (1) and 10-O-acetylmacrophyllide (2) together with six known iridoids; 6β-hydroxygenipin (3), genipin (4), garjasmine (5), cerbinal (6), and mixture of β-gardiol (7) and α-gardiol (8); benzoic acid (9); vanillic acid (10); and stigmasterol (11). Their structures were elucidated by spectroscopic methods. Iridoid 1 showed antimycobacterial activity against Mycobacterium tuberculosis with a MIC value of 12.50μg/mL. Iridoid 2 showed cytotoxicity against the NCI-H187 cancer cell line with an IC50 value of 6.82μg/mL. In addition, 2 and 5 exhibited weak cytotoxic activity against KB and MCF-7 cell lines, while 4 was active against the NCI-H187 cancer cell line.
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