Gambogic acid - CAS 2752-65-0
Catalog number: B0005-464620
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Gambogic acid, which can be found in the herbs of Garcinia hanburyi Hook. F, is a potent anticancer agent and has been found effective against various types of cancer cells. Gambogic acid has significant anti-inflammatory properties and can possibly constitute a prototype anti-inflammatory drug with therapeutic efficacy in the treatment of inflammatory diseases such as RA.
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B0005-464620 50 mg $198 In stock
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Yellow Solid
beta-Guttiferin; (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid
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1. Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells
Hongyan Gu • Shuyun Rao • Jie Zhao • Jia Wang • Rong Mu • Jingjing Rong • Lei Tao • Qi Qi. J Cancer Res Clin Oncol (2009) 135:1777–1782
Gambogic acid is known as an anticancer compound since it was characterized to be an apoptosis inducer. Induction of mitochondrial-dependent and -independent apoptosis pathway by Gambogic acid had been evidenced before (Pandey et al. 2007; Zhao et al. 2004). As a broad-spectrum repressor of cancer cell growth, GA inhibited MCF-7 cell growth in a time- and concentration-dependent manner (Gu et al. 2008a, b). In this study, we demonstrated that Gambogic acid induced human breast cancer cells MCF-7 apoptosis by reducing bcl-2 expression via p53 and highlighted the importance of p53 in GA induced cell apoptosis. Since the 50% inhibiting concentration (IC50) of Gambogic acid to MCF-7 cells was approximately 4 M (Gu et al. 2008a,b) and this concentration of GA caused less cell death but was suYcient to enhance p53 expression (see Fig. S1 in Electronic Supplementary Material) compared to the higher concentration such as 8μm, we decided to use 4 μm Gambogic acid as the optimal experimental condition.
2. Gambogic Acid Sensitizes Ovarian Cancer Cells to Doxorubicin Through ROS-Mediated Apoptosis
Jianxia Wang • Zhixiang Yuan. Cell Biochem Biophys (2013) 67:199–206
Gambogic acid is the principle active component derived from gamboge, a dry resin of various Garcinia species. The therapeutic effects of gambogic acid including anti-inflammatory, anti-oxidant, anti-viral, and anti-infectious have been recorded in Traditional Chinese Medicine documents. In addition, it is reported that gambogic acid could induce apoptosis in human breast cancer cells and hepatoma cells. Studies also reveal that gambogic acid can significantly suppress the growth of various cancer cells in vitro and in vivo. Besides its role as a single-agent anticancer drug, gambogic acid exhibited synergistic effect with conventional chemother-apeutics including 5-fluoracil, oxaliplatin, and docetaxel against human gastric intestinal cancer cells and with proteasome inhibitor murine hepatoma cells. However, whether gambogic acid could enhance cytotoxicity of Dox has yet to be investigated.
3. PEG–PLGA–PLL nanoparticles in combination with gambogic acid for reversingmultidrug resistance of K562/A02 cells to daunorubicin
Peipei Xu, Ruju Wang, Jian Li, Jian Ouyanga and Bing Chen*. RSC Adv.,2015, 5,61051–61059
The natural product gambogic acid (GA, C38H44O8) is the active ingredient of gamboge, the resin purified from Garcinia hanburyi. GA has demonstrated diverse effects such as anti-oxidant, anti-inflammatory and anti-infection properties. GA has also been used as a promising anticancer agent to inhibit the growth of various cancer cells; studies have shown that GA can enhance the apoptosis of MG-63 and K562/A02 cells when combined with cisplatin (CDDP) and DNR, respectively, indicating the synergistic effect of GA with CDDP and DNR. Substantial research has stated that GA can resynthesise cancer cells which have required resistance to anticancer drugs, such as GC-823/Doc cell lines of gastric cancer to docetaxel and K562/A02 cell lines of leukaemia to adriamycin. However, the clinical application of GA has been impeded because of poor aqueous solubility, severe side effects and toxicity in normal cells and tissues. Thus, GA should be modied with particular materials.
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CAS 2752-65-0 Gambogic acid

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