Gambogic acid - CAS 2752-65-0
Catalog number: B0005-464620
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Chemical Family:
Other Natural Compounds
Gambogic acid, which can be found in the herbs of Garcinia hanburyi Hook. F, is a potent anticancer agent and has been found effective against various types of cancer cells. Gambogic acid has significant anti-inflammatory properties and can possibly constitute a prototype anti-inflammatory drug with therapeutic efficacy in the treatment of inflammatory diseases such as RA.
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-464620 50 mg $198 In stock
Bulk Inquiry
Yellow Solid
beta-Guttiferin; (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid
Canonical SMILES:
1. Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells
Hongyan Gu • Shuyun Rao • Jie Zhao • Jia Wang • Rong Mu • Jingjing Rong • Lei Tao • Qi Qi. J Cancer Res Clin Oncol (2009) 135:1777–1782
Gambogic acid is known as an anticancer compound since it was characterized to be an apoptosis inducer. Induction of mitochondrial-dependent and -independent apoptosis pathway by Gambogic acid had been evidenced before (Pandey et al. 2007; Zhao et al. 2004). As a broad-spectrum repressor of cancer cell growth, GA inhibited MCF-7 cell growth in a time- and concentration-dependent manner (Gu et al. 2008a, b). In this study, we demonstrated that Gambogic acid induced human breast cancer cells MCF-7 apoptosis by reducing bcl-2 expression via p53 and highlighted the importance of p53 in GA induced cell apoptosis. Since the 50% inhibiting concentration (IC50) of Gambogic acid to MCF-7 cells was approximately 4 M (Gu et al. 2008a,b) and this concentration of GA caused less cell death but was suYcient to enhance p53 expression (see Fig. S1 in Electronic Supplementary Material) compared to the higher concentration such as 8μm, we decided to use 4 μm Gambogic acid as the optimal experimental condition.
2. Gambogic Acid Sensitizes Ovarian Cancer Cells to Doxorubicin Through ROS-Mediated Apoptosis
Jianxia Wang • Zhixiang Yuan. Cell Biochem Biophys (2013) 67:199–206
Gambogic acid is the principle active component derived from gamboge, a dry resin of various Garcinia species. The therapeutic effects of gambogic acid including anti-inflammatory, anti-oxidant, anti-viral, and anti-infectious have been recorded in Traditional Chinese Medicine documents. In addition, it is reported that gambogic acid could induce apoptosis in human breast cancer cells and hepatoma cells. Studies also reveal that gambogic acid can significantly suppress the growth of various cancer cells in vitro and in vivo. Besides its role as a single-agent anticancer drug, gambogic acid exhibited synergistic effect with conventional chemother-apeutics including 5-fluoracil, oxaliplatin, and docetaxel against human gastric intestinal cancer cells and with proteasome inhibitor murine hepatoma cells. However, whether gambogic acid could enhance cytotoxicity of Dox has yet to be investigated.
3. PEG–PLGA–PLL nanoparticles in combination with gambogic acid for reversingmultidrug resistance of K562/A02 cells to daunorubicin
Peipei Xu, Ruju Wang, Jian Li, Jian Ouyanga and Bing Chen*. RSC Adv.,2015, 5,61051–61059
The natural product gambogic acid (GA, C38H44O8) is the active ingredient of gamboge, the resin purified from Garcinia hanburyi. GA has demonstrated diverse effects such as anti-oxidant, anti-inflammatory and anti-infection properties. GA has also been used as a promising anticancer agent to inhibit the growth of various cancer cells; studies have shown that GA can enhance the apoptosis of MG-63 and K562/A02 cells when combined with cisplatin (CDDP) and DNR, respectively, indicating the synergistic effect of GA with CDDP and DNR. Substantial research has stated that GA can resynthesise cancer cells which have required resistance to anticancer drugs, such as GC-823/Doc cell lines of gastric cancer to docetaxel and K562/A02 cell lines of leukaemia to adriamycin. However, the clinical application of GA has been impeded because of poor aqueous solubility, severe side effects and toxicity in normal cells and tissues. Thus, GA should be modied with particular materials.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Other Natural Compounds Products


(CAS: 5119-48-2)

WITHAFERIN A, also referred to as D004, NSC 101088, used as an important medicinal herb for over 3000 years, is a steroidal lactone derived from Acnistus arbore...

CAS 22798-96-5 Ecdysterone 20,22-monoacetonide

Ecdysterone 20,22-monoacetonide
(CAS: 22798-96-5)

Ecdysterone 20,22-monoacetonide isolated from the roots of Cyanotis arachnoidea C. B. Clarke.

CAS 56-84-8 L(+)-Aspartic acid

L(+)-Aspartic acid
(CAS: 56-84-8)

L-Aspartic Acid is a non-essential amino acid found in food sources and dietary supplements. L-Aspartic Acid is one of the 20 proteinogenic amino acids; the bui...

Dregeoside A11
(CAS: 89020-11-1)

Dregeoside A11 isolated from the herbs of Dregea volubilis.

CAS 77-92-9 Citric Acid

Citric Acid
(CAS: 77-92-9)

Citric acid is a weak organic acid that is known as a commodity chemical, as more than a million tonnes are produced every year by mycological fermentation on a...

Methyl 4-O-feruloylquinate
(CAS: 195723-10-5)

Methyl 4-O-feruloylquinate is a natural compound found in several plants.

CAS 139051-27-7 Anemarsaponin B

Anemarsaponin B
(CAS: 139051-27-7)

Anemarsaponin B could inhibit PAF-induced rabbitplatelet aggregation in vitro.

CAS 526-87-4 Conduritol A

Conduritol A
(CAS: 526-87-4)

Conduritol A isolated from the barks of Marsdenia condurango. It has an effect on regulating the metabolism of blood lipid.

CAS 13190-97-1 Solanesol

(CAS: 13190-97-1)

Solanesol, a high molecular weight isoprenoid alcohol isolated from tobacco leaf, could protect ethanol-induced L02 cell damage, which might be attributed to th...

CAS 1220891-22-4 3,4-Dihydro-3,4-dihydroxynaphthalen-1(2H)-one

(CAS: 1220891-22-4)

3,4-Dihydro-3,4-dihydroxynaphthalen-1(2H)-one isolated from the herb of Impatiens balsamina.

(CAS: 145033-48-3)

Digalactosyldiacylglycerol is a natural compound found in several plants.

CAS 13059-93-3 alpha-Terthienylmethanol

(CAS: 13059-93-3)

alpha-Terthienylmethanol isolated from the herbs of Eclipta alba. It inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub...

CAS 23696-85-7 damascenone

(CAS: 23696-85-7)

CAS 481-18-5 α-Spinasterol

(CAS: 481-18-5)

Alpha-Spinasterol, a natural steroid found in the roots of Bupleurum chinense DC, exhibits the activity of anti-inflammatory and antinociceptive effects against...

CAS 463-40-1 α-Linolenic acid

α-Linolenic acid
(CAS: 463-40-1)

α-Linolenic acid (ALA) is an omega-3 fatty acid that occurs as the glyceride in most drying oils. It has an inhibitory effect on prostaglandin thus reduces infl...

CAS 91652-78-7 Senkyunolide C

Senkyunolide C
(CAS: 91652-78-7)

<br/>Senkyunolide C is a natural compound found in several plants.

CAS 465-13-4 Neritaloside

(CAS: 465-13-4)

Neritaloside isolated from the herbs of Nerium indicum Mill. It exhibits central nervous system depressant activity in mice

CAS 6217-54-5 Docosahexaenoic acid

Docosahexaenoic acid
(CAS: 6217-54-5)

Docosahexaenoic acid (DHA) is an omega-3 fatty acid found in fish oil and a major component of excitable membranes of the retina and brain. It decreases the lev...

CAS 171422-85-8 Otophylloside B 4'''-O-β-D-cymaropyranoside

Otophylloside B 4'''-O-β-D-cymaropyranos
(CAS: 171422-85-8)

Otophylloside B 4'''-O-β-D-cymaropyranoside is a steroid compound isolated from the leaves of Cryptolepis buchanani.

CAS 177602-14-1 Glycerol 1-(26-hydroxyhexacosanoate)

Glycerol 1-(26-hydroxyhexacosanoate)
(CAS: 177602-14-1)

Glycerol 1-(26-hydroxyhexacosanoate) comes from the herbs of Isodon sculponeata

Chemical Structure

CAS 2752-65-0 Gambogic acid

Quick Inquiry

Verification code

Featured Items