Gallic acid - CAS 149-91-7
Catalog number: 149-91-7
Not Intended for Therapeutic Use. For research use only.
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Gallic acid is a natural phenolic compound, it has cytotoxic activity in relation to their radical modulating activity, induce apoptosis by different mechanisms, and gallic acid produces higher amounts of radicals and more efficiently scavenged the superoxide anion radical. Gallic acid also exhibits the activitise of anti-tyrosinase,antioxidant and anti-inflammatory.
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3,4,5-trihydroxybenzoic acid
anti-tyrosinase; antioxidant; anti-inflammatory
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1. Intermolecular Interactions in Aqueous Solutions of Gallic Acid at 296–306 K According to Spectrof luorimetry and Densimetry Data
K. R. Grigoryan and L. S. Sargsyan. Russian Journal of Physical Chemistry A, 2015, Vol. 89, No. 12, pp. 2234–2237
Gallic acid (3, 4, 5-trihydroxybenzoic acid, GA) and its derivatives are biologically active. They belong to the family of easily hydrolyzable natural polyphenolic compounds. The field of application of natural polyphenols is quite wide: they are mainly used as antimicrobial, antibacterial, and antioxidant agents. The preferential intermolecular interactions in aqueous solutions of polyphenolic compounds affect their reactivity, which plays a crucial role in regulating the interactions between Gallic acid (GA) and biological compounds. Data on preferential intermolecular interactions can be obtained by means of spectroscopy (electronic absorption and f luorescence) and conventional study methods (e.g., viscometry, densimetry). To thoroughly study the interactions between Gallic acid (GA) and biomolecules (in particular, proteins), we need a comprehensive understanding how GA behaves in aqueous solutions, depending on different physicochemical parameters of the solution (e.g., solvent type, presence of a co-solvent, pH, temperature, concentration of a compound). Below, we present the results from the studies on the effect of temperature and concentration on intermolecular interactions in aqueous Gallic acid (GA) solutions by means of f luorescence spectroscopy and densimetry.
2. TLC Densitometric Method for the Quantification of Eugenol and Gallic Acid in Clove
S. B. Pathak, K. Niranjan, H. Padh, M. Rajani*. Chromatographia 2004, 60, August (No. 3/4)
Accurately weighed 0.5 g quantities of powder of different samples of clove were separately extracted with methanol (4 • 25 mL) under reflux (30 min each time) in a water bath. The pooled extracts of each sample were concentrated and transferred to separate 100 mL volumetric flasks individually and their volumes were made up with methanol. These solutions were used for the estimation of gallic acid in the samples. Preliminary TLC experiments showed that amount of eugenol was much higher than the amount of gallic acid in the sample extract. Hence, it was found to be necessary to dilute the sample extract, so that the concentration of eugenol in the sample extract applied falls within the calibration range. For the estimation of eugenol, 1 mL aliquot of each sample solution was diluted to 5 mL with methanol.
3. Isolation and TLC Densitometric Quantification of Gallicin, Gallic Acid, Lupeol and b-Sitosterol from Bergia suffruticosa, a Hitherto Unexplored Plant
Sheetal Anandjiwala, Honnegowda Srinivasa, Mandapati Rajani. Chromatographia 2007, 66, November (No. 9/10)
The free radical scavenging activity of the whole plant of B. suffruticosa reported by us earlier and its use as a poultice on sores can be attributed among others to the presence of all these four compounds since all of them were reported to have antioxidant and anti-inflammatory activities. The antimicrobial activity of B. suffruticosa can be attributed to the presence of gallicin, gallic acid andβ-sitosterol. The ethnomedical use of the plant in stomach troubles can be attributed to the presence of gallic acid as it was reported to show gastric protective action. Since gallicin, gallic acid, lupeol and β-sitosterol have shown to possess interesting biological activities, by virtue they can serve as biomarkers.
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CAS 149-91-7 Gallic acid

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