|Description||Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. It is is a non-depolarising muscle relaxant.|
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reductio...
Biperiden is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker. It is used for the adjunctive treatment of all forms of Park...
Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors.
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially coup...
Tiotropium Bromide, an azoniatricyclo derivative, is a mAChR antagonist that could be used as bronchodilation agent and smooth muscle relaxant.
Tolterodine has a high affinity and specificity for muscarinic receptors in vitro and it exhibits selectivity for the urinary bladder over salivary glands in vi...
Xanomeline is a Muscarinic M1 and M4 receptor agonist under the development of Eli Lilly, though it is also known to act as a M5 receptor antagonist. Xanomeline...
Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic.
A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
Tubocurarine hydrochloride pentahydrate
Tubocurarine is a toxic alkaloid. It is an acetylcholine receptor (AChR)-blocking agent. Tubocurarine is now rarely used as an adjunct for clinical anesthesia b...
A selective muscarinic receptor stimulant, used to treat cerebral palsy.
Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced c...
Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-ch...
Cevimeline hydrochloride is a selective M1 receptor agonist.
5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladde...
Alvameline, also known as Lu25-109, is a partial M1agonist and M2/M3antagonist that was progressed into clinical studies for the treatment of Alzheimer's diseas...
Darifenacin hydrobromide is an antispasmodic muscarinic antagonist, selective for blocking the M3 muscarinic acetylcholine receptor, which is primarily responsi...
Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 μM in concentration-dependent manner.
Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.