Galanthamine - CAS 357-70-0
Catalog number:
357-70-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H21NO3
Molecular Weight:
287.36
COA:
Inquire
Targets:
AChE
Description:
Galanthamine, also called Razadyne, found in GALANTHUS and other AMARYLLIDACEAE, a cholinesterase inhibitor prescribed to treat symptoms of mild to moderate Alzheimer's, enhances cholinergic function accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
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Brife Description:
A cholinesterase inhibitor
Appearance:
Off-White to Pale Yellow Solid
Synonyms:
galanthamine; Galantamine; Reminyl; 357-70-0; Lycoremine; (-)-Galanthamine; Galantamin; Lycoremin; Jilkon; Nivalin; Razadyne; Galantamina; Galanthaminum; Galantaminum; Razadyne ER; Galantaminum [INN-Latin]; CHEMBL659; 1qti; Ortho McNeil Neurologics Brand of Galantamine; Ortho-McNeil Neurologics Brand of Galantamine
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
MSDS:
Inquire
Boiling Point:
439.3°C at 760 mmHg
InChIKey:
ASUTZQLVASHGKV-JDFRZJQESA-N
InChI:
1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
Canonical SMILES:
CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
1.Galanthamine as bis-functional ligand for the acetylcholinesterase
Edgar Luttmann, Elmar Linnemann, Gregor Fels. J Mol Model (2002) 8:208–216
Independently from the FlexX scoring methods we developed a scoring procedure for the interaction of galanthamine derivatives with the PAS, more specifically with the indole system of Trp279. In this respect we looked at four parameters: (i) the centroid distance (d in Fig. 2) between the galanthamine a-ring and the unweighted geometric center of the nine indole ring atoms, (ii) the angle (α in Fig. 2) that is spanned between these two aromatic ring planes, (iii) the angle between the normal on Trp279 and the vector between the two centroids (ω in Fig. 2) which corresponds to a co-latitude with respect to polar coordinates, and (iv) the space fill value which determines the relative overlapping volume between a sphere of 5 Å radius around the centroid of Trp279 with the atomic van der Waals radii of the ligand atoms.
2.IDENTIFICATION AND EVALUATION OF PURITY OF THE PARENT SUBSTANCE AND MEDICINAL FORM OF GALANTHAMINE HYDROBROMIDE
I. Yu. Novikova and A. A. Tulaganov. Pharmaceutical Chemistry Journal Vol. 36, No. 7, 2002
It should be noted that all spots are observed on the chromatogram only provided that not less than 75 μg of the drug from a parent substance solution or a medicinal form is applied onto the TLC plate. Upon application of a 50-μg sample, we observed only one additional spot with Rf= 0.54 – 0.55. As the amount of sample applied on the TLC plate is increased to 200 μg, the absorption spots significantly increase and begin to overlap. The most clear separation of the spots of galanthamine hydrobromide and impurities was observed upon application of 75 – 100 μg of the drug from a parent substance solution or a medicinal form. As can be seen from Table 3, the TLC patterns revealed additional spots, the mutual arrangement and coloration of which were the same for the parent substance solution and the medicinal form. From this we may conclude that both samples of galanthamine hydrobromide contained impurities, probably foreign alkaloids introduced in the course of drug manufacture.
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CAS 357-70-0 Galanthamine

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