Galangin - CAS 548-83-4
Catalog number:
548-83-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10O5
Molecular Weight:
270.2
COA:
Inquire
Targets:
Others
Description:
Galangin is a flavonoid naturally found in herbs acts as an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
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Purity:
≥98%
Appearance:
Yellow powder
Synonyms:
3,5,7-Trihydroxyflavone; 3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on; 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Anti-proliferation/CYP1A1 inhibitor/vasodilator
Quality Standard:
Enterprise Standard/CP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
VCCRNZQBSJXYJD-UHFFFAOYSA-N
InChI:
1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
Canonical SMILES:
C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
1.Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress.
Madduma Hewage SR1, Piao MJ1, Kim KC1, Cha JW1, Han X1, Choi YH2, Chae S3, Hyun JW1. Biomol Ther (Seoul). 2015 Mar;23(2):165-73. doi: 10.4062/biomolther.2014.130. Epub 2015 Mar 1.
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
2.Combined Autodock and comparative molecular field analysis study on predicting 5-lipoxygenase inhibitory activity of flavonoids isolated from Spatholobus suberectus Dunn.
Jiang S, Huang K, Liu W, Fu F, Xu J. Z Naturforsch C. 2015;70(3-4):103-13. doi: 10.1515/znc-2014-4110.
5-Lipoxygenase (5-LOX) plays a key role in the pathway of leukotriene biosynthesis. To predict the inhibitory activity of flavonoid inhibitors against 5-LOX from Spatholobus suberectus Dunn, Autodock 4.2 and comparative molecular field analysis (CoMFA) were employed. For the positive inhibitors (n=7), the value of the coefficient of determination (R2) between the binding free energy, calculated using Autodock 4.2, and the experimental pIC50 is 0.838. In the training set (n=21) of inhibitors against 5-LOX, the R2 of non-cross-validated partial least squares analysis between the actual and predicted pIC50 values, using the no-validation with the optimum number of components set to 6, is 0.997 (p=0.000). For the model generated by CoMFA, the contribution of electrostatic and steric factors are 0.522 and 0.478, respectively. Among the flavonoids of S. suberectus, liquiritigenin, catechin, butin, 3',4',7-trihydroxyflavone, plathymenin, and gallocatechin are the more potent inhibitors of 5-LOX based on the calculated binding free energy and the predicted pIC50 value.
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CAS 548-83-4 Galangin

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