|Targets||Factor Xa | Ser/Thr Protease|
|Description||Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis.|
|Synonyms||4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate; Gabexate; Gabexate mesylate; gabexate mesilate. Arodate; Megacart; Megacert; Mesyl Gabexate; Arodate.|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor. Study in vitro showed that it inhibited exogenous uPA in human chronic w...
Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It...
Fondaparinux sodium is a factor Xa inhibitor that mediates the interaction of herparin with antithrombins. It is used for the prevention of venous thromboemboli...
GSK583 is a selective receptor-interacting serine/threonine-protein kinase 2 (RIP2 Kinase) inhibitor and the RIP2K binding IC50 is 5 nM. GSK583 can inhibit both...
Leupeptin reversibly inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B ...
Edoxaban is an oral factor Xa (FXa) inhibitor, also contraindicated in patients with active pathological bleeding.
Nafamostat is a broad spectrum serine protease inhibitor and kallikrein inhibitor. It inhibits blood coagulation and used as an anticoagulant. It is also a poss...
BMS-344577 is aroylguanidine-based lactam derivative, which is a potent FXa inhibitor (FXa IC(50)=4 nM, EC(2xPT)=7 microM).