Gabapentin enacarbil - CAS 478296-72-9
Catalog number: 478296-72-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
Calcium Channel
Description:
Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin.
Publictions citing BOC Sciences Products
  • >> More
Purity:
0.98
Synonyms:
Horizant; Regnite; XP-13512
MSDS:
Inquire
1.Modified-Release Formulations of Second-Generation Antiepileptic Drugs: Pharmacokinetic and Clinical Aspects.
Anderson GD1, Saneto RP2. CNS Drugs. 2015 Aug;29(8):669-81. doi: 10.1007/s40263-015-0268-5.
Modified-release or extended-release (XR) formulations are used to decrease the frequency of dosing for drugs with rapid elimination, to improve convenience and adherence. Use of a modified-release formulation can decrease the peak to trough fluctuations in serum concentrations and theoretically improve the therapeutic benefit of the drug, by decreasing adverse events associated with the higher peak concentrations. Once-daily formulations of lamotrigine (Lamictal XR(®)), levetiracetam (Keppra XR(®)), oxcarbazepine (Oxtellar XR(®), Apydan(®) extent) and topiramate (Qudexy XR™, Trokendi XR™) are approved for the treatment of focal and/or generalized onset seizures. Other seizure medications have been approved for non-epileptic symptoms. Gabapentin XR (Gralise(®)) is approved for the treatment of post-herpetic neuralgias. Gabapentin enacarbil XR (Horizant(®)) is a prodrug of gabapentin and is indicated for treatment of post-herpetic neuralgia and restless leg syndrome, a novel indication.
2.Gabapentin enacarbil and morphine administered in combination versus alone: a double-blind, randomized, pharmacokinetic, and tolerability comparison.
Chen C1, Upward J2, Arumugham T3, Stier B3, Davy M2. Clin Ther. 2015 Feb 1;37(2):349-57. doi: 10.1016/j.clinthera.2014.10.015. Epub 2014 Nov 20.
PURPOSE: Coadministration of morphine with oral gabapentin has been shown to increase plasma gabapentin concentrations. This study evaluated whether there was any interaction between gabapentin enacarbil (GEn), which is a prodrug of gabapentin, and morphine in terms of pharmacokinetics, pharmacodynamics, safety, and tolerability.
3.The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome.
Avidan AY1, Lee D2, Park M3, Jaros MJ4, Shang G5, Kim R5. CNS Drugs. 2016 Apr 11. [Epub ahead of print]
OBJECTIVE: The aim was to assess gabapentin enacarbil (GEn) treatment effects on quality of life (QOL) and mood in adults with moderate-to-severe primary restless legs syndrome (RLS).
4.Impact of Data Imputation Methodology on Pain Assessment over 24 Hours in a Randomized, Placebo-Controlled Study of Gabapentin Enacarbil in Patients with Neuropathic Pain Associated with Postherpetic Neuralgia.
Calkins AM1, Gudin J2, Gidal B3, Jaros MJ4, Kim R5, Shang G6. Pain Med. 2016 Jan 6. pii: pnv072. [Epub ahead of print]
OBJECTIVE: To assess the impact of gabapentin enacarbil on primary and secondary pain endpoints using three data imputation methodologies in a randomized phase II study of adult patients with postherpetic neuralgia.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Calcium Channel Products


CAS 357400-13-6 NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride
(CAS: 357400-13-6)

NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)

CAS 484-12-8 Osthole

Osthole
(CAS: 484-12-8)

Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also reg...

CAS 14663-23-1 Dantrolene Sodium

Dantrolene Sodium
(CAS: 14663-23-1)

Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...

OPC 13463
(CAS: 73372-63-1)

OPC 13463 is one of the metabolites of pranidipine. Pranidipine is a long acting calcium channel antagonist of the dihydropyridine group.

CAS 128229-52-7 TAMOLARIZINE

TAMOLARIZINE
(CAS: 128229-52-7)

Tamolarizin is a calcium antagonist originated by Nippon Chemiphar. Tamolarizin can induce the increase of GABA in the cerebellum and medulla oblongata followin...

S(-)-BAY K 8644
(CAS: 98625-26-4)

S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the...

CAS 26864-56-2 Penfluridol

Penfluridol
(CAS: 26864-56-2)

Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutic...

CAS 63675-72-9 Nisoldipine

Nisoldipine
(CAS: 63675-72-9)

Nisoldipine is a calcium channel blocker, specific for L-type Cav1.2 with IC50 of 10 nM.

CAS 1380341-99-0 GAL-021

GAL-021
(CAS: 1380341-99-0)

GAL-021 a novel intravenous BKCa-channel blocker potentially for the treatment of respiratory depression.

CAS 116644-53-2 Mibefradil

Mibefradil
(CAS: 116644-53-2)

Mibefradil, a calcium channel blocker, has modest selectivity for T-type Ca2+ channels so that could be used in the treatment of sorts of cardiovascular disease...

CAS 116308-56-6 Watanipidine monohydrochloride

Watanipidine monohydrochloride
(CAS: 116308-56-6)

Watanipidine, also called as AE 0047 or Calbren, is a calcium channel antagonist.

CAS 68291-97-4 Zonisamide

Zonisamide
(CAS: 68291-97-4)

Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and r...

CAS 60142-96-3 Gabapentin

Gabapentin
(CAS: 60142-96-3)

Gabapentin is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also note...

CAS 30484-77-6 Flunarizine Dihydrochloride

Flunarizine Dihydrochloride
(CAS: 30484-77-6)

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

CAS 123524-52-7 Azelnidipine

Azelnidipine
(CAS: 123524-52-7)

Azelnidipine is a dihydropyridine calcium channel blocker.

CAS 21829-25-4 Nifedipine

Nifedipine
(CAS: 21829-25-4)

Nifedipine is a dihydropyridine calcium channel blocker that primarily blocks L-type calcium channels.Its main uses are as an antianginal (especially inPrinzmet...

Mirogabalin
(CAS: 1138245-13-2)

This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which...

PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

CAS 180090-15-7 CP-​060

CP-​060
(CAS: 180090-15-7)

CP-​060 is a novel type of Ca(2+) antagonist possessing both Ca(2+) overload inhibition, with antioxidant and cardioprotective activities.

ABT-639
(CAS: 1235560-28-7)

ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found to have potential effect against neuropathic and nociceptive pain in studies. It...

Chemical Structure

CAS 478296-72-9 Gabapentin enacarbil

Quick Inquiry

Verification code

Featured Items