Gabapentin - CAS 60142-96-3
Catalog number: 60142-96-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H17NO2
Molecular Weight:
171.24
COA:
Inquire
Targets:
Calcium Channel
Description:
Gabapentin is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive.
Purity:
>98%
MSDS:
Inquire
InChIKey:
UGJMXCAKCUNAIE-UHFFFAOYSA-N
InChI:
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
Canonical SMILES:
C1CCC(CC1)(CC(=O)O)CN
1.The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome.
Avidan AY1, Lee D2, Park M3, Jaros MJ4, Shang G5, Kim R5. CNS Drugs. 2016 Apr 11. [Epub ahead of print]
OBJECTIVE: The aim was to assess gabapentin enacarbil (GEn) treatment effects on quality of life (QOL) and mood in adults with moderate-to-severe primary restless legs syndrome (RLS).
2.Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial.
Lewis SC1, Bhattacharya S2, Wu O3, Vincent K4, Jack SA5, Critchley HO6, Porter MA2, Cranley D7, Wilson JA8, Horne AW6. PLoS One. 2016 Apr 12;11(4):e0153037. doi: 10.1371/journal.pone.0153037. eCollection 2016.
TRIAL REGISTRATION: Controlled-Trials.com ISRCTN45178534.
3.Diabetic Sensory and Motor Neuropathy.
N Engl J Med. 2016 Apr 13. [Epub ahead of print]
Diabetic Sensory and Motor Neuropathy Clinical Practice, N Engl J Med 2016;374:1455-1464. In Table 1 (page 1457), in the second entry in the third column, "impaired autonomic dysfunction" should have been "impaired autonomic function." The third entry in the first column should have been "Recognize clinical implications." The fifth entry in the first column should have been "Consider differential diagnosis." In Table 2 (pages 1460-1), the initial dose of topiramate should have been 25 mg/day, and the effective dose 25-100 mg/day. For gabapentin, the upper bound of the confidence interval for the number needed to treat should have been 8.3. The effective dose of amitriptyline should have been 25-150 mg/day. The effective dose of tramadol should have been 100-200 mg/day, and the number needed to treat should have been 4.7. In the final sentence of the second paragraph under Areas of Uncertainty (page 1461), the term "(frank deficiency)" should not have appeared.
4.Analyzing Relationship Between Monoclonal Gammopathy of Undetermined Significance (MGUS) with Different Types of Neuropathy: An Observational Study.
Nabi S1, Kahlon P1, Bozorgnia F2, Arshad A3, Saleem A4, Kuriakose P5. Indian J Hematol Blood Transfus. 2016 Jun;32(2):186-92. doi: 10.1007/s12288-015-0547-9. Epub 2015 May 28.
To analyze multiple variables, including immunoglobulin subtypes in patients with monoclonal gammopathy of undetermined significance (MGUS) and different types of neuropathy. This was a retrospective, single center study done in a tertiary care hospital in the United States. The data was collected for years 2001-2011. Inclusion criteria were the presence of MGUS and neuropathy. Exclusion criteria were the presence of other factors such as diabetes, vitamin B12 deficiency, alcoholism etc. which can cause neuropathy. Patients with IgM MGUS were compared with patients having Non-IgM MGUS. A total of 281 patients were analyzed in this study. The average age at the time of diagnosis of MGUS and neuropathy was 68 years. The most common type of neuropathy was sensorimotor peripheral neuropathy (46 %). The most common location of neuropathy was the lower extremities (68 %). Among our patients, 52 % had their neuropathy symptoms for 1-5 years before presenting to the clinic.
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CAS 60142-96-3 Gabapentin

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