|Description||Gabapentin is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive.|
CGS 9343B is a calmodulin (CaM) antagonist that inhibits calmodulin-stimulated cAMP phosphodiesterase activity (an IC50 = 3.3 nM). It also prevents estrogen-ind...
L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxid...
Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.
Flindokalner, an anxiolytic agent, is a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Flindokalner can b...
Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...
Lavendustin C, also known as HDBA and NSC 666251, inhibits Ca2+/CaMKII (calmodulin kinase II) (IC50=0.2 μM), EGFR tyrosine kinase (IC50=44 nM) and SRC (IC50=0.5...
Calmidazolium chloride has been found to be a calcium channel protein inhibitor as well as a calmodulin antagonist.
CI 951 is a dihydronaphthyridine Ca2+ channel antagonist and it may be applicated for the treatment of focal cerebral ischemia. CI 951 has potential as a cerebr...
Tetrandrine is a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore. Tetrandrine exhibits very broad pharmacological acti...
ω-Conotoxin GVIA is a peptide neurotoxin first isolated from the marine snail Conus geographus L. It selectively and reversibly blocks specific voltage-dependen...
Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. It could also present as the hydro...
NP-118809 is a N-type calcium channel blocker exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain...
Efonidipine hydrochloride monoethanolate
The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders.
Nisoldipine is a calcium channel blocker, specific for L-type Cav1.2 with IC50 of 10 nM.
Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels.
Watanipidine, also called as AE 0047 or Calbren, is a calcium channel antagonist.
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is used in the treatment of primary (essential) hypertension to decrease bloo...
Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
Nicardipine is a calcium channel blocker used to treat high blood pressure and angina.