|Description||Gabapentin is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive.|
GV-58, a pupin derivative, has been found to be a P/Q-type Ca²⁺-channel agonist that could be used to against neuromuscular weakness. IC50: 7.21/8.81 uM (N-type...
The hydrochloride salt form of Lercanidipine, a dihydropyridine derivative, could be used as an antihypertensive agent through influencing the L-type Ca2+ chann...
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels.
Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also reg...
Amlodipine maleate is a long-acting dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker). It inhibits the movement of calcium ion...
S(-)-BAY K 8644
S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the...
Lercanidipine hydrochloride, a dihydropyridine compound, is a third generation calcium channel antagonist which shows longer duration of action of the past two ...
McN5691, an antihypertensive agent, is a voltage-sensitive calcium channel blocker.
NNC 55-0396 dihydrochloride
NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)
This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which...
Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by ...
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset ...
Nisoldipine is a calcium channel blocker, specific for L-type Cav1.2 with IC50 of 10 nM.
Mibefradil dihydrochloride hydrate
The dihydrochloride hydrate salt form of Mibefradil which is a calcium channel blocker with modest selectivity for T-type Ca2+ channels so that it could be used...
Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia as a p...
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is used in the treatment of primary (essential) hypertension to decrease bloo...
NS-638 is a small nonpeptide Ca(2+)-channel blocker.
Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...