|Description||Gabapentin is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive.|
S(-)-BAY K 8644
S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the...
Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and r...
Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Tetracaine hydrochlorideis a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activit...
Cinnarizine, with antiallergic and anti-vasoconstricting activity, is a calcium channel blocker to treat cerebral apoplexy, post-trauma cerebral symptoms, and c...
Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.
OPC 13463 is one of the metabolites of pranidipine. Pranidipine is a long acting calcium channel antagonist of the dihydropyridine group.
The hydrochloride salt form of Lercanidipine, a dihydropyridine derivative, could be used as an antihypertensive agent through influencing the L-type Ca2+ chann...
PD0176078 is a novel N-type calcium channel blocker.
The hydrochloride salt form of Fendiline, a benzenepropanamine derivative, has been found to be a calcium channel blocker and alpha2-adrenergic receptor antagon...
Dopropidil, also called as ORG 30701, is a cardioactive drug to be classified as a calcium antagonist with combined class I and class VI antiarrhythmic properti...
Mesuximide is a succinimide anticonvulsant medication. The therapeutic efficacy of methosuximide is due to its pharmacologically active metabolite, N-desmethylm...
Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.
A calcium channel modulator that blocks aortic contraction (IC50= 0.8 μM)
Lavendustin C, also known as HDBA and NSC 666251, inhibits Ca2+/CaMKII (calmodulin kinase II) (IC50=0.2 μM), EGFR tyrosine kinase (IC50=44 nM) and SRC (IC50=0.5...
NNC 55-0396 dihydrochloride
NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is used in the treatment of primary (essential) hypertension to decrease bloo...
Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.
The hydrochloride salt form of Efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channel...