G-TPP - CAS 1131626-46-4
Catalog number: 1131626-46-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C52H65N3O8P
Molecular Weight:
890.85
COA:
Inquire
Targets:
Hsp90
Description:
G-TPP is a mitochondria-targeted Hsp90 inhibitor that increases cell death in HeLa and MCF7 cells, consistently inhibits cell death induced by oxidative stress and mitochondrial dysfunction induced by PINK1 mutation in mouse embryonic fibroblast cells and DA cell models such as SH-SY5Y and SN4741 cells. Additionally, G-TPP also suppresses the defective locomotive activity and DA neuron loss in Drosophila PINK1 null mutants.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
G-TPP is a mitochondria-targeted Hsp90 inhibitor
Purity:
>98%
Appearance:
Solid powder
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Hsp90 Products


CAS 940289-57-6 VER-49009

VER-49009
(CAS: 940289-57-6)

VER-49009 is a pyrazole compound inhibitor of Hsp90, IC50 47 nM. It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cance...

BIIB028
(CAS: 911398-13-5)

BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may lead to the proteasomal degradation of these proteins and the inhibition of tumor ce...

CAS 908112-43-6 SNX-2112

SNX-2112
(CAS: 908112-43-6)

SNX-2112 is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGF...

KF-25706
(CAS: 184537-25-5)

KF25706 is derivative of radicicol, binds to the Hsp90 chaperone machinery, IC50 39nM.

CAS 934343-74-5 Hsp990

Hsp990
(CAS: 934343-74-5)

Hsp980 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.  Hsp980 binds to and inhibits the acti...

CAS 819812-04-9 KW-2478

KW-2478
(CAS: 819812-04-9)

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be ...

CAS 70563-58-5 Herbimycin A

Herbimycin A
(CAS: 70563-58-5)

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL...

CAS 1134156-31-2 VER-155008

VER-155008
(CAS: 1134156-31-2)

VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.It targets the nucleotide-binding doma...

CAS 959763-06-5 CH5138303

CH5138303
(CAS: 959763-06-5)

CH5138303 is a novel and potent Hsp90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd=0.52nM) and strong in vitro cell growth inhibi...

PU-H71 trihydrochloride

PU-H71 trihydrochloride is a potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM) that inhibits cell growth and induces cell apoptosis in triple-neg...

NW457
(CAS: 1373761-12-6)

NW-457 is a potent Hsp90 inhibitor with no detectable hepatocytotoxicity in vitro. It synergizes with ionizing irradiation to induce chromatin condensation, nuc...

NXD30001
(CAS: 1223580-83-3)

NXD30001 inhibits Hsp90, potentially resulting in decreased tumor growth.

CAS 888216-25-9 Ganetespib

Ganetespib
(CAS: 888216-25-9)

Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhib...

Ratester
(CAS: 854485-83-9)

Radester is a hybrid composed of radicicol's resorcinol and geldanamycin’s benzoquinone part structures and exhibits good cellular activity against MCF7 breast ...

CAS 958025-66-6 MPC-3100

MPC-3100
(CAS: 958025-66-6)

MPC-3100 targets the N-terminal ATP-binding site of Hsp90 and blocks the activity of ATPase. In the Her2-luciferase degradation assay, MPC-3100 reduces this cli...

CAS 12772-57-5 Radicicol

Radicicol
(CAS: 12772-57-5)

Radiocicol is an antifungal antibiotic. It inhibits heat Hsp90 activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induc...

Sansalvamide A
(CAS: 227084-43-7)

Sansalvamide A binds directly to Hsp90 and modulate Hsp90's binding with client proteins.

Pochonin D
(CAS: 544712-82-5)

Pochocin D is a patent Hsp90 inhibitor. IC50 80.0nM.

CAS 303-81-1 Novobiocin

Novobiocin
(CAS: 303-81-1)

Novobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the interaction of both p23 and Hsp70 co-chaperones ...

CAS 848695-25-0 BIIB021

BIIB021
(CAS: 848695-25-0)

BIIB021 is An orally active, purine-scaffold, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. BIIB021 that is ...

Quick Inquiry

Verification code

Featured Items