Furilazole - CAS 121776-33-8
Catalog number:
121776-33-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H13Cl2NO3
Molecular Weight:
278.13
COA:
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Targets:
Others
Description:
Furilazole, an oxazole derivative, is a herbicide commonly used for gramineous crops.
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Purity:
98%
Appearance:
Powder
Synonyms:
(RS)-3-Dichloroacetyl-5-(2-furanyl)-2,2-dimethyl-1,3-oxazolidine
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
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Application:
Furilazole is a herbicide commonly used for gramineous crops.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
MCNOFYBITGAAGM-UHFFFAOYSA-N
InChI:
InChI=1S/C11H13Cl2NO3/c1-11(2)14(10(15)9(12)13)6-8(17-11)7-4-3-5-16-7/h3-5,8-9H,6H2,1-2H3
Canonical SMILES:
CC1(N(CC(O1)C2=CC=CO2)C(=O)C(Cl)Cl)C
1.Simultaneous detection of fluquinconazole and flusilazole in lettuce using gas chromatography with a nitrogen phosphorus detector: decline patterns at two different locations.
Im SJ1, Rahman MM1, Abd El-Aty AM2,3, Kim SW1, Kabir H1, Farha W1, Lieu T1, Lee YJ1, Jung DI1, Choi JH1, Shin HC2, Im GJ4, Hong SM4, Shim JH1. Biomed Chromatogr. 2016 Jun;30(6):946-52. doi: 10.1002/bmc.3634. Epub 2015 Nov 12.
Method validations in addition to decline patterns of fluquinconazole and flusilazole in lettuce grown under greenhouse conditions at two different locations were investigated. Following the application of fluquinconazole and flusilazole at a dose rate of 20 mL/20 L water, lettuce samples were collected randomly for up to 7 days post-application, and simultaneously extracted with acetone, purified through solid-phase extraction, analyzed via gas chromatography with a nitrogen phosphorus detector, and confirmed through gas chromatography-mass spectrometry. The linearity was excellent, with determination coefficients (R(2) ) between 0.9999 and 1.0. The method was validated in triplicate at two different spiking levels (0.2 and 1.0 mg/kg) with satisfactory recoveries between 75.7 and 97.9% and relative standard deviations of <9. The limit of quantification was 0.01 mg/kg. Both analytes declined very quickly, as can be seen from the short half-life time of <4 days.
2.Flusilazole induces spatio-temporal expression patterns of retinoic acid-, differentiation- and sterol biosynthesis-related genes in the rat Whole Embryo Culture.
Dimopoulou M1, Verhoef A2, van Ravenzwaay B3, Rietjens IM4, Piersma AH2. Reprod Toxicol. 2016 Apr 14. pii: S0890-6238(16)30053-3. doi: 10.1016/j.reprotox.2016.04.003. [Epub ahead of print]
Embryotoxic responses are critically dependent on the timing of exposure during embryo development. Here, we examined the time- dependent developmental effects in rat embryos exposed to flusilazole (FLU), and their link to retinoic acid (RA) mediated pathways. To this end, we assessed the effects of 4h exposure of rat embryos in vitro to 300μM FLU during four developmental time windows (0-4, 4-8, 24-28 and 44-48h), evaluating morphological parameters, expression and localization of five genes directly or indirectly linked with the RA pathway. These were RA- (Cyp26a1 and Dhrs3), differentiation- (Gbx2 and Cdx1) and sterol biosynthesis- (Cyp51) related genes. Extended exposure for 48h to 300μM FLU resulted in morphological changes, typical for triazoles and RA, while the 4h exposure times did not. Time dependent significant upregulation of the five selected genes was observed. These results corroborate that the embryotoxic responses to FLU are correlated with the regulation of the RA pathway.
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CAS 121776-33-8 Furilazole

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