1.Drug-sensitivity of El Tor vibrio strains isolated in the Philippines in 1964 and 1965.
Kuwahara S, Goto S, Kimura M, Abe H. Bull World Health Organ. 1967;37(5):763-71.
About 1500 strains of El Tor vibrios, isolated in 1964 and 1965 in the Philippines, were examined for their susceptibilities to 17 drugs. All the strains tested were highly sensitive to dihydroxymethyl-furalazine, and most were highly sensitive to tetracycline hydrochloride, chloramphenicol and erythromycin, and moderately sensitive to novobiocin, dihydrostreptomycin sulfate, kanamycin and neomycin. They showed a remarkable fluctuation of sensitivity to ampicillin, cefaloridine, cefalotin and sulfafurazole, and a high resistance to benzylpenicillin sodium, oleandomycin and spiramycin.Experimental confirmation was provided of the fact that El Tor vibrios and non-agglutinable vibrios can be distinguished from classical cholera vibrios by their resistance to polymyxin B and colistin.Highly streptomycin-resistant strains, and to a lesser extent ampicillin- and sulfafurazole-resistant strains, were relatively often isolated from cholera patients who had been treated with antibiotics.
2.Antibiotic-resistant strains of E1 Tor vibrio in the Philippines and the use of furalazine for chemotherapy.
Kobari K, Takakura I, Nakatomi M, Sogame S, Uylangco C. Bull World Health Organ. 1970;43(3):365-71.
Among 1109 patients with bacteriologically confirmed El Tor cholera admitted to the San Lazaro Hospital, Manila, in 1969, 11 patients continued to excrete vibrios of the same biotype and serotype in stools for more than 1 week in spite of antibiotic treatment.The strains isolated from these patients all belonged to the Ogawa serotype and were all highly resistant to streptomycin and chloramphenicol, and a few of them were resistant also to tetracycline. Other streptomycin-resistant strains of El Tor vibrio were detected, 5 in the Greater Manila area and 1 in Bacolod.The antibiotic-resistant strains showed a high sensitivity to 3 kinds of antimicrobial chemicals, particularly dihydroxymethyl furalazine.Furalazine was given to 33 adults and 15 children with bacteriologically confirmed cholera, and its effect in reducing the duration of diarrhoea and excretion of vibrios was investigated in comparison with the same number of cases treated with chloramphenicol.