Funapide - CAS 1259933-16-8
Catalog number: 1259933-16-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H14F3NO5
Molecular Weight:
429.35
COA:
Inquire
Targets:
Sodium Channel
Description:
Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
UNII-A5595LHJ2L; A5595LHJ2L; XEN-401-S; TV-45070; (7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
chronic painconditions
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
NEBUOXBYNAHKFV-NRFANRHFSA-N
InChI:
InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1
Canonical SMILES:
C1C2(C3=CC=CC=C3N(C2=O)CC4=CC=C(O4)C(F)(F)F)C5=CC6=C(C=C5O1)OCO6
Current Developer:
Teva Pharmaceutical Industries; Xenon Pharmaceuticals
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 2609-46-3 Amiloride

Amiloride
(CAS: 2609-46-3)

Amiloride, a pyrazine derivative potassium-sparing diuretic, is a blocker of sodium channel in renal epithelial cells. Amiloride blocked the low threshold Ca2+ ...

CAS 550-83-4 Propoxycaine hydrochloride

Propoxycaine hydrochloride
(CAS: 550-83-4)

Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine used to control the pain of intramuscular injection of penicillin as well as in dentis...

CAS 6108-05-0 Lidocaine hydrochloride monohydrate

Lidocaine hydrochloride monohydrate
(CAS: 6108-05-0)

Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...

CAS 66794-74-9 Encainide Hydrochloride

Encainide Hydrochloride
(CAS: 66794-74-9)

Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated so...

T-1095
(CAS: 209746-59-8)

T-1095, with potential antidiabetic effect, is an inhibitor of renal Na+-glucose cotransporters that may provide a novel way to treating diabetes.

PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

CAS 536-43-6 Dyclonine Hydrochloride

Dyclonine Hydrochloride
(CAS: 536-43-6)

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.

CAS 85-79-0 Dibucaine

Dibucaine
(CAS: 85-79-0)

Dibucaine is an anesthetic of the amide type. It is mainly used for surface anesthesia and now restricted to use in spinal and topical anesthesia. It reduced th...

CAS 1234365-97-9 Tenapanor HCl

Tenapanor HCl
(CAS: 1234365-97-9)

Tenapanor, also known as AZD-1722 and RDX 5791, is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. Tenapanor ...

PF-04856264
(CAS: 1235397-05-3)

This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...

CAS 1443373-17-8 AM-2099

AM-2099
(CAS: 1443373-17-8)

AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50= 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM).

Sodium Channel inhibitor 1
(CAS: 1198117-23-5)

Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatm...

AZD-3161
(CAS: 1369501-46-1)

AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.

CAS 28721-07-5 Oxcarbazepine

Oxcarbazepine
(CAS: 28721-07-5)

Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50...

Nav1.7 inhibitor
(CAS: 1355631-24-1)

Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia.

CAS 1432913-36-4 GX-674

GX-674
(CAS: 1432913-36-4)

GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly express...

CAS 54143-56-5 Flecainide Acetate

Flecainide Acetate
(CAS: 54143-56-5)

Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle

Eleclazine
(CAS: 1443211-72-0)

Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and en...

Funapide
(CAS: 1259933-16-8)

Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...

CAS 212778-82-0 Elpetrigine

Elpetrigine
(CAS: 212778-82-0)

Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...

Quick Inquiry

Verification code

Featured Items