|Description||Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials.|
|Synonyms||UNII-A5595LHJ2L; A5595LHJ2L; XEN-401-S; TV-45070; (7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Teva Pharmaceutical Industries; Xenon Pharmaceuticals|
OD1 is a rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator. It exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5. OD1 can induce sponta...
PF 04885614 is a potent and selective Nav1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), with selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNa...
Tetrodotoxin, citrate (1:1) (salt)
Tetrodotoxin, citrate (1:1) (salt), also called as TTX citrate, is the citrate salt of tetrodotoxin. Tetrodotoxin is a neurotoxin that reversibly and selectivel...
4,9-Anhydrotetrodotoxin is a derivative of tetrodotoxin, which is a potent neurotoxin and can be isolated from pufferfish. It is also a selective and potent Nav...
Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...
VX-150 is a NaV1.8 blocker which is currently in a phase II clinical trial for the treatment of patients with acute pain. Study shows that VX-150 significantly ...
Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, sta...
Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And ...
Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium c...
ProTx II is a selective NaV1.7 channel blocker with 100-fold selectivity over other sodium channel subtypes.
This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...
QX 314 chloride
QX 314 chloride, a membrane-impermeant lidocaine derivative, is a blocker of voltage-activated Na+ channels. QX-314 elicits a long-lasting decrease in the respo...
A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).
Lidocaine hydrochloride monohydrate
Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...
ProTx III, isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens, is a potent Nav1.7 blocker (IC50 = 2.5 nM) and also inhibits Nav...
BDS I is a reversible Kv3.4 potassium channel blocker (IC50 = 47 nM) and Nav1.7 channel agonist. BDS I potentiates TTX-sensitive sodium currents in rat small do...
A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). A 887826 is effective on reducing tactile all...
PA 1 dihydrochloride is a photoswitchable epithelial sodium channel blocker with IC50 values of 90 and 390 nM for αβγ and δβγENaCs in the trans conformation.
Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.
PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50= 31nM) for the treatment of pain. But P...