FTY720 - CAS 162359-56-0
Catalog number: B0084-060268
Category: Inhibitor
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LPL Receptor
Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM.
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Catalog Number Size Price Stock Quantity
B0084-060268 5 g $298 In stock
B0084-060268 10 g $498 In stock
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Fingolimod hydrochloride; FTY720; FTY 720; FTY-720
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1.Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery.
Resop RS1, Douaisi M2, Craft J2, Jachimowski LC3, Blom B3, Uittenbogaart CH4. J Allergy Clin Immunol. 2016 Apr 4. pii: S0091-6749(16)00290-6. doi: 10.1016/j.jaci.2015.12.1339. [Epub ahead of print]
BACKGROUND: The mechanisms that govern the egress of mature thymocytes from the human thymus to the periphery remain understudied yet are of utmost importance to the field of basic immunology, as well as T-cell reconstitution in various immunodeficiencies. We examined the expression and function of sphingosine-1-phosphate (S1P) receptors in human thymocyte egress.
2.Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.
Willems LM1, Zahn N1, Ferreirós N2, Scholich K2, Maggio N3,4, Deller T1, Vlachos A5,6. Acta Neuropathol Commun. 2016 Mar 31;4(1):28. doi: 10.1186/s40478-016-0303-x.
A hallmark of several major neurological diseases is neuronal cell death. In addition to this primary pathology, secondary injury is seen in connected brain regions in which neurons not directly affected by the disease are denervated. These transneuronal effects on the network contribute considerably to the clinical symptoms. Since denervated neurons are viable, they are attractive targets for intervention. Therefore, we studied the role of Sphingosine-1-phosphate (S1P)-receptor signaling, the target of Fingolimod (FTY720), in denervation-induced dendritic atrophy. The entorhinal denervation in vitro model was used to assess dendritic changes of denervated mouse dentate granule cells. Live-cell microscopy of GFP-expressing granule cells in organotypic entorhino-hippocampal slice cultures was employed to follow individual dendritic segments for up to 6 weeks after deafferentation. A set of slice cultures was treated with FTY720 or the S1P-receptor (S1PR) antagonist VPC23019.
3.Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia.
Nazari M1, Keshavarz S2, Rafati A3, Namavar MR4, Haghani M5. Brain Res Bull. 2016 Apr 8. pii: S0361-9230(16)30078-8. doi: 10.1016/j.brainresbull.2016.04.004. [Epub ahead of print]
Fingolimod (FTY720) is a known sphingosine-1-phosphate (S1P) receptor agonist. Several studies have shown the therapeutic efficacy of FTY720 in neurodegenerative disorders. However, the neuroprotective mechanisms in brain ischemia have not been adequately studied. Therefore, the present study aimed to investigate the effects of FTY720 on the impairment of learning and memory and hippocampal synaptic plasticity induced by middle cerebral artery occlusion (MCAO) in ischemic brain injury. Twenty eight male rats were randomly divided into four groups of control (n=7), sham (n=8), ischemic-reperfusion+vehicle (I/R+V; n=7), and I/R+FTY720 (n=6). After 1hour of the occlusion of artery, the filament was gently withdrawn to allow reperfusion for the next 7 days. The animals first received a dose of FTY720 (0.5mg/Kg) or its vehicle (intra-peritoneal) twenty-four hours before surgery in I/R+FTY720 and I/R+V groups, respectively. The administration of FTY720 or its vehicle continued every other day.
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CAS 162359-56-0 FTY720

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