FTI-276 - CAS 170006-72-1
Catalog number:
170006-72-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Description:
FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene.
Publictions citing BOC Sciences Products
  • >> More
Synonyms:
FTI-276; FTI276; FTI 276.
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Chemical Structure

CAS 170006-72-1 FTI-276

Quick Inquiry

Verification code

Featured Items