Frovatriptan Succinate - CAS 158930-09-7
Catalog number: 158930-09-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H23N3O5
Molecular Weight:
361.40
COA:
Inquire
Targets:
5-HT Receptor
Description:
Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Frovatriptan succinate; (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide butanedioate;1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-, butanedioate (1:1);Sb-209509ax;Vml 251
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
InChIKey:
WHTHWNUUXINXHN-SBSPUUFOSA-N
InChI:
InChI=1S/C14H17N3O.C4H6O4/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8)/t9-;/m1./s1
Canonical SMILES:
CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N.C(CC(=O)O)C(=O)O
1.[Frovatriptan possibly causing acute myocardial infarction].
Møller-Helgestad OK1, Kaltoft AK, Kasch H. Ugeskr Laeger. 2015 Mar 23;177(13):V10140537.
Globally migraine affects more than 10% of the adult population and it is treated with simple analgesics, combined with a triptan for a stronger treatment effect. Triptans cause arterial vasoconstriction, and this is a case report of vasospasm-induced acute myocardial infarction in a 61-year-old woman with frequent episodic migraine attacks treated with triptans. She was possibly also suffering from medication overuse headache. We suggest that regular frovatriptan use may have contributed to the myocardial infarction and that long-term triptan use may have caused the medication overuse headache.
2.Variability of the characteristics of a migraine attack within patients.
Viana M1, Sances G2, Ghiotto N2, Guaschino E2, Allena M2, Nappi G2, Goadsby PJ3, Tassorelli C4. Cephalalgia. 2015 Oct 23. pii: 0333102415613612. [Epub ahead of print]
BACKGROUND: Migraine attacks may present different features in different patients and also within the same patient. The percentage of patients reporting stereotyped attacks and those reporting attacks with different phenotypes has not been the object of specific investigations.
3.Factors associated with frovatriptan response in patients with migraine: A prospective, observational study.
Seo JG1, Park SP2. Cephalalgia. 2015 Jul 13. pii: 0333102415596443. [Epub ahead of print]
BACKGROUND: Almost one-third of patients with migraine do not adequately respond to triptans. We examined factors contributing to frovatriptan response in patients with migraine.
4.The therapeutic armamentarium in migraine is quite elderly.
Martelletti P1. Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):175-7. doi: 10.1517/17425255.2015.982089. Epub 2014 Dec 1.
Global Burden of Disease 2010 study considers migraine as one of the most important noncommunicable diseases in the world, classifying it third in terms of global prevalence (14.70%): it sums up the 54.19% of all the years of life lived with disabilities caused by the rest of all neurological disorders. This Editorial provides an historical excursus of old and new-entry molecules in migraine therapeutic area. Drugs for acute treatment such as triptans date back to the early 1990s with the appearance of sumatriptan and the following six triptans in the years immediately after (zolmitriptan, rizatriptan, naratriptan, eletriptan, almotriptan, frovatriptan). Prophylaxis drugs, dedicated to patients with medium/high frequency of crises, show as last entries topiramate and botulinum toxin type A. The use of this preventative group, with its intrinsic limits, is mandatory to reduce the risk of migraine chronification, a highly harmful clinical phenomenon that produces as its natural consequence the medication overuse headache.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 170911-68-9 Donitriptan hydrochloride

Donitriptan hydrochloride
(CAS: 170911-68-9)

The hydrochloride salt form of Donitriptan, which is a novel 5-HT derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors a...

CAS 13523-86-9 Pindolol

Pindolol
(CAS: 13523-86-9)

Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).

CAS 149007-54-5 (S)-WAY 100135 dihydrochloride

(S)-WAY 100135 dihydrochloride
(CAS: 149007-54-5)

(S)-WAY 100135 dihydrochloride is a potent and selective 5-HT1A receptor antagonist (IC50 = 15 nM).

CAS 168986-60-5 RS 67333 hydrochloride

RS 67333 hydrochloride
(CAS: 168986-60-5)

RS 67333 hydrochloride is a selective, high affinity partial agonist toward 5-HT4 receptor with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 ...

CAS 740873-06-7 Naluzotan

Naluzotan
(CAS: 740873-06-7)

Naluzotan is a selective 5-HT1A receptor partial agonist under the development of EPIX Pharmaceuticals. It is a serotonergic drug for the treatment of generaliz...

CAS 361-37-5 Methysergide

Methysergide
(CAS: 361-37-5)

Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide for the treatment of vascular headache

CAS 179756-85-5 Eptapirone

Eptapirone
(CAS: 179756-85-5)

Eptapirone, a triazine derivative, has been found to be a 5-HT1A receptor agonist and was once studied as an antidepressant agent. pKi: 8.33.

CAS 139290-69-0 MDL 100151

MDL 100151
(CAS: 139290-69-0)

MDL 100151 is the racemic MDL 100907 and a selective 5-HT2A antagonist.

CAS 158876-82-5 Rupatadine

Rupatadine
(CAS: 158876-82-5)

Rupatadine, with the potential to treat allergic rhinitis and urticaria, is a potent and long-lasting dual antagonist of PAF/H1. in vitro: Without affecting con...

CAS 133920-70-4 FK 960

FK 960
(CAS: 133920-70-4)

FK 960 is a somatostatin receptor agonist and a 5-HT agonist activating both serotonin and somatostatin production as a cognitive enhancer. The phase II clinica...

CAS 634908-75-1 WAY-100635 maleate

WAY-100635 maleate
(CAS: 634908-75-1)

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist for 5-HT ( IC50= 0.95 ± 0.12 nM ), and also exhibits agonist activity at dopamine ...

CAS 191592-09-3 5-HT2 antagonist 1

5-HT2 antagonist 1
(CAS: 191592-09-3)

A potent antagonist of 5-HT2 receptor

CAS 1171123-46-8 EMD 386088 hydrochloride

EMD 386088 hydrochloride
(CAS: 1171123-46-8)

EMD 386088 hydrochloride is a potent and selective 5-HT6 receptor agonist (EC50 = 1.0 nM) (IC50 = 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1...

CAS 85181-40-4 Tropanyl-3,5-dimethylbenzoate

Tropanyl-3,5-dimethylbenzoate
(CAS: 85181-40-4)

Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist.

CAS 1539266-32-4 NBOH-2C-CN hydrochloride

NBOH-2C-CN hydrochloride
(CAS: 1539266-32-4)

NBOH-2C-CN hydrochloride is a selective 5-HT2A agonist.

PR-073

PR-073 is a novel 5-HT7 antagonist, which can inhibit immune responses and treat inflammatory bowel disease (IBD). Preclinical studies demonstrated that PR-073 ...

CAS 58-39-9 Perphenazine

Perphenazine
(CAS: 58-39-9)

Perphenazine is a typical antipsychotic. a piperazinyl phenothiazine, used to treat psychosis

CAS 172895-39-5 LY 266097 hydrochloride

LY 266097 hydrochloride
(CAS: 172895-39-5)

LY 266097 hydrochloride is a 5-HT2B receptor antagonist. It can attenuate amphetamine-induced locomotion in the rat.

LY 293284
(CAS: 141318-62-9)

LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A ...

CAS 199673-74-0 LY 334370 hydrochloride

LY 334370 hydrochloride
(CAS: 199673-74-0)

LY 334370 hydrochloride is a 5-HT1F receptor agonist. It shows antimigraine effects.

Chemical Structure

CAS 158930-09-7 Frovatriptan Succinate

Quick Inquiry

Verification code

Featured Items