Frovatriptan Succinate - CAS 158930-09-7
Catalog number:
158930-09-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H23N3O5
Molecular Weight:
361.40
COA:
Inquire
Targets:
5-HT Receptor
Description:
Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.
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Purity:
98%
Appearance:
Powder
Synonyms:
Frovatriptan succinate; (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide butanedioate;1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-, butanedioate (1:1);Sb-209509ax;Vml 251
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
InChIKey:
WHTHWNUUXINXHN-SBSPUUFOSA-N
InChI:
InChI=1S/C14H17N3O.C4H6O4/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8)/t9-;/m1./s1
Canonical SMILES:
CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N.C(CC(=O)O)C(=O)O
1.[Frovatriptan possibly causing acute myocardial infarction].
Møller-Helgestad OK1, Kaltoft AK, Kasch H. Ugeskr Laeger. 2015 Mar 23;177(13):V10140537.
Globally migraine affects more than 10% of the adult population and it is treated with simple analgesics, combined with a triptan for a stronger treatment effect. Triptans cause arterial vasoconstriction, and this is a case report of vasospasm-induced acute myocardial infarction in a 61-year-old woman with frequent episodic migraine attacks treated with triptans. She was possibly also suffering from medication overuse headache. We suggest that regular frovatriptan use may have contributed to the myocardial infarction and that long-term triptan use may have caused the medication overuse headache.
2.Variability of the characteristics of a migraine attack within patients.
Viana M1, Sances G2, Ghiotto N2, Guaschino E2, Allena M2, Nappi G2, Goadsby PJ3, Tassorelli C4. Cephalalgia. 2015 Oct 23. pii: 0333102415613612. [Epub ahead of print]
BACKGROUND: Migraine attacks may present different features in different patients and also within the same patient. The percentage of patients reporting stereotyped attacks and those reporting attacks with different phenotypes has not been the object of specific investigations.
3.Factors associated with frovatriptan response in patients with migraine: A prospective, observational study.
Seo JG1, Park SP2. Cephalalgia. 2015 Jul 13. pii: 0333102415596443. [Epub ahead of print]
BACKGROUND: Almost one-third of patients with migraine do not adequately respond to triptans. We examined factors contributing to frovatriptan response in patients with migraine.
4.The therapeutic armamentarium in migraine is quite elderly.
Martelletti P1. Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):175-7. doi: 10.1517/17425255.2015.982089. Epub 2014 Dec 1.
Global Burden of Disease 2010 study considers migraine as one of the most important noncommunicable diseases in the world, classifying it third in terms of global prevalence (14.70%): it sums up the 54.19% of all the years of life lived with disabilities caused by the rest of all neurological disorders. This Editorial provides an historical excursus of old and new-entry molecules in migraine therapeutic area. Drugs for acute treatment such as triptans date back to the early 1990s with the appearance of sumatriptan and the following six triptans in the years immediately after (zolmitriptan, rizatriptan, naratriptan, eletriptan, almotriptan, frovatriptan). Prophylaxis drugs, dedicated to patients with medium/high frequency of crises, show as last entries topiramate and botulinum toxin type A. The use of this preventative group, with its intrinsic limits, is mandatory to reduce the risk of migraine chronification, a highly harmful clinical phenomenon that produces as its natural consequence the medication overuse headache.
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CAS 158930-09-7 Frovatriptan Succinate

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