Frentizole - CAS 26130-02-9
Catalog number:
26130-02-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H13N3O2S
Molecular Weight:
299.35
COA:
Inquire
Targets:
Amyloid-β
Description:
Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly improved activity (IC50 = 200 lM) compared to thioflavine T(IC50 = 230 lM).
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Brife Description:
An FDA-approved immunosuppressive drug, a novel inhibitor of the Aβ–ABAD interaction (IC50 = 200 lM)
Appearance:
Solid powder
Synonyms:
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; 7EY946394I; frentizole; mono-hydrate of frentizole; FRENTIZOLE; 26130-02-9; Frentizol; Compound 53616; MLS000555007; CHEMBL128988; UNII-7EY946394I; 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; NCGC00160657-01; SMR000147124; 1-(6-Methoxy-benzothiazol-2-yl)-3-phenyl-urea; DSSTox_CID_26279; DSSTox_RID_81505; 1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylurea; DSSTox_GSID_46279; CAS-26130-02-9; Frentizolum; Frenazole; AC1Q4EVH; Frentizole (USAN/INN); Opera_ID_1653; Frentizol [INN-Spanish]; Frentizolum [INN-Latin]; AC1L1PF2; Oprea1_516941; cid_33334; MLS001201824; Bio-0413; Frentizole [USAN:INN:BAN]; SCHEMBL599582; DTXSID5046279; HMS2233G12; HMS3370C02; ZINC8994439; Tox21_111964; 3684AH; BDBM50189352; STK078558; ZINC08994439; AKOS001049350; Tox21_111964_1; 7EY946394I; CS-0841; MCULE-7561551977; NCGC00160657-03; AK468739; DR001179; HE329695; HY-15374; LY 53616; ST50103599; 1-(6-Methoxy-2-benzothiazolyl)-3-phenylurea; 1-(6-methoxybenzothiazol-2-yl)-3-phenylurea; D00159; W-5046; Urea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-; 3-(6-methoxy-1,3-benzothiazol-2-yl)-1-phenylurea; N-(6-methoxybenzothiazol-2-yl)(phenylamino)carboxamide; T0510-0233
Solubility:
DMSO: ≥ 3 mg/mL
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -22℃ for long term (months to years).
MSDS:
Inquire
Application:
Anti-Alzheimer agents; Amyloid-β inhibitor
InChIKey:
JHBWYQRKOUBPCA-UHFFFAOYSA-N
InChI:
1S/C15H13N3O2S/c1-20-11-7-8-12-13(9-11)21-15(17-12)18-14(19)16-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
Canonical SMILES:
COC1=CC2=C(C=C1)N=C(S2)NC(=O)NC3=CC=CC=C3
1.Comparative effects of azathioprine, cyclophosphamide and frentizole on cellular immunity in mice.
Smith SR, Terminelli C, Kipilman CT, Smith Y. J Immunopharmacol. 1981;3(2):133-70.
This report extends previous observations on the immunosuppressive properties of cyclophosphamide (CPA), azathioprine and frentizole (15) to include murine models of cellular immunity. Systemic and local graft vs host reactions (GVHR) were most effectively suppressed by CPA. In contrast to frentizole, both CPA and azathioprine were found to inhibit the proliferation of parental T-cells in a systemic GVHR. However, CPA was the only agent capable of inhibiting the proliferation of T-cells following contact sensitization with oxazolone. Mice pretreated with a high dose of CPA or frentizole prior to inoculation with the murine sarcoma virus exhibited accelerated tumor growth. However, there was no accelerated growth of murine sarcoma virus induced tumors or an SaI spindle cell fibrosarcoma during rather prolonged therapy with immunosuppressive doses of CPA, azathioprine or frentizole. Normal mice treated with CPA showed a more drastic reduction in lymphoid elements of the spleen and thymus than mice treated with azathioprine or frentizole.
2.Frentizole therapy in systemic lupus erythematosus.
Sabharwal UK, Vaughan JH, Kaplan RA, Robinson CA, Curd JG. Arthritis Rheum. 1980 Dec;23(12):1376-80.
Seven corticosteroid dependent patients with active systemic lupus erythematosus (SLE) were given frentizole in order to assess its effect on their clinical manifestations. Three patients exhibited slight clinical improvement, 2 patients did not change, and 2 deteriorated. Five of the 7 patients developed subclinical and reversible liver damage related to frentizole. This study, although preliminary and uncontrolled, suggests that frentizole is of limited value in the management of patients with SLE.
3.The immunomodulatory action of frentizole, a novel immunosuppressive agent.
Hatfield SM, Hartley LW, Schmidtke JR. Immunopharmacology. 1982 Dec;5(2):169-79.
The in vitro effects of frentizole and methylprednisolone on human PBL were examined. Both drugs exhibited differential effects on lymphocyte subpopulations. Frentizole was more effective in suppressing human lymphocytes responding to Con A and PWM, than it was in cells activated by PHA, specific antigen, or alloantigen. Methylprednisolone, on the other hand, was more inhibitory for cells stimulated by PHA, specific antigen, or alloantigen. These data suggest that frentizole has a preferential effect on the cytotoxic/suppressor subpopulation of human T lymphocytes while methylprednisolone appears to preferentially affect the helper/inducer subset. Differences in potency between the two drugs were also observed. Methylprednisolone was better able to maintain its inhibitory effects during longer periods of culture than frentizole. Both agents were less effective if their addition to the culture was delayed 24-48 hrs and neither drug was very effective in overcoming the adjuvant action of poly A:U on mitogenically activated human PBL.
4.Frentizole therapy of thrombocytopenia in systemic lupus erythematosus and refractory idiopathic thrombocytopenic purpura.
O'Duffy JD, Colgan JP, Phyliky RL, Ferguson RH. Mayo Clin Proc. 1980 Oct;55(10):601-5.
Frentizole, an immunosuppressive phenylurea agent, used in a dosage of 4 mg/kg per day, was found to produce quick elevation of platelet counts in three thrombocytopenic patients. Two have systemic lupus erythematosus, and one has resistant idiopathic thrombocytopenic purpura. Corticosteroid dosage could be reduced in all three patients, and thus far platelet counts are being maintained at "safe" levels. Although major toxicity has limited the utility of frentizole, its effect on the platelet counts of these thrombocytopenic patients is of interest.
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CAS 26130-02-9 Frentizole

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