Fraxin - CAS 524-30-1
Catalog number:
524-30-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H18O10
Molecular Weight:
370.32
COA:
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Description:
Fraxin is extracted from the bark of Fraxinus brngeana DC. It is a glucoside of fraxetin, an O-methylated coumarin. It protects HUVECs from oxidative stress. It has anti-inflammatory effects. It enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice.
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Purity:
>98%
Appearance:
White powder
Synonyms:
8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one;7,8-Dihydroxy-6-methoxycoumarin 8-β-D-glucopyranoside;8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxycoumarin;Fraxetin-8-O-glucoside;2H-1-Benzopyran-2-one, 8-(beta-D-glucopyranosyloxy)-7
Solubility:
Freely soluble in hot water, hot alcohol; sparingly in cold water; practically insoluble in ether
Storage:
2-8ºC
MSDS:
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Application:
Fraxin protects HUVECs from oxidative stress. It has anti-inflammatory effects.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
722.2±60.0 °C | Condition: Press: 760 Torr
Melting Point:
200 °C
Density:
1.634±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
CRSFLLTWRCYNNX-QBNNUVSCSA-N
InChI:
InChI=1S/C16H18O10/c1-23-7-4-6-2-3-9(18)25-14(6)15(11(7)20)26-16-13(22)12(21)10(19)8(5-17)24-16/h2-4,8,10,12-13,16-17,19-22H,5H2,1H3/t8-,10-,12+,13-,16+/m1/s1
Canonical SMILES:
COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC3C(C(C(C(O3)CO)O)O)O)O
1.Simultaneous determination of fraxin and its metabolite, fraxetin, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Wang H1, Xiao B1, Hao Z1, Sun Z2. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:70-4. doi: 10.1016/j.jchromb.2016.02.030. Epub 2016 Feb 23.
For the first time, a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of fraxin and its metabolite, fraxetin, in rat plasma, using esculin as the internal standard (IS). The plasma samples were precipitated with methanol before separation on an Nova-Pak C18 column (150mm×3.9mm, 3μm) using a mobile phase consisting of 0.1% formic acid and methanol (55:45) at a flow rate of 0.8mL/min. The analytes were detected by multiple reaction monitoring in the negative ion mode with the mass transitions at m/z 368.9→ m/z 191.9 (fraxin), m/z 206.9→ m/z 191.8 (fraxetin) and m/z 339.0→ m/z 176.9 (esculin, IS). The results demonstrated that the calibration curves for both analytes have good linearity (r≥0.995) over a concentration range of 5.00-3000ng/mL. The assay was validated according to the regulatory bioanalytical guidelines and proved acceptable.
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CAS 524-30-1 Fraxin

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