FR-221647 - CAS 256461-28-6
Catalog number: 256461-28-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H17N3O2
Molecular Weight:
259.3
COA:
Inquire
Targets:
Adenosine Deaminase
Description:
FR-221647 is a non-nucleoside adenosine deaminase inhibitor.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
1-(1-hydroxy-4-phenylbutan-2-yl)imidazole-4-carboxamide; FR-221647; FR 221647; FR221647
MSDS:
Inquire
InChIKey:
ZUYUIKKHHBEVHL-UHFFFAOYSA-N
InChI:
1S/C14H17N3O2/c15-14(19)13-8-17(10-16-13)12(9-18)7-6-11-4-2-1-3-5-11/h1-5,8,10,12,18H,6-7,9H2,(H2,15,19)
Canonical SMILES:
C1=CC=C(C=C1)CCC(CO)N2C=C(N=C2)C(=O)N
1.Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.
Terasaka T;Nakanishi I;Nakamura K;Eikyu Y;Kinoshita T;Nishio N;Sato A;Kuno M;Seki N;Sakane K Bioorg Med Chem Lett. 2003 Mar 24;13(6):1115-8.
We searched for non-nucleoside inhibitors of adenosine deaminase by rational structure-based de novo design and succeeded in the discovery of 1-(1-hydroxy-4-phenyl-2-butyl)imidazole-4-carboxamide (FR221647: K(i)=5.9 microM to human ADA) as a novel inhibitor with moderate activity and good pharmacokinetics compared with the known inhibitors pentostatin and EHNA.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adenosine Deaminase Products


CAS 53910-25-1 Pentostatin

Pentostatin
(CAS: 53910-25-1)

Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells. Pent...

FR-221647
(CAS: 256461-28-6)

FR-221647 is a non-nucleoside adenosine deaminase inhibitor.

CAS 14432-09-8 1-Deazaadenosine

1-Deazaadenosine
(CAS: 14432-09-8)

1-Deazaadenosine is an adenosine deaminase inhibitor and has been found to show antitumor activity in some leukemia cell lines.

CAS 58337-38-5 EHNA hydrochloride

EHNA hydrochloride
(CAS: 58337-38-5)

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosine deaminase. EHNA i...

FR-234938
(CAS: 256461-79-7)

FR-234938, with anti-inflammatory property, is a non-nucleoside recombinant human adenosine deaminase enzyme inhibitor.

CAS 4291-63-8 Cladribine

Cladribine
(CAS: 4291-63-8)

Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

Quick Inquiry

Verification code

Featured Items