FR-194921 - CAS 202646-80-8
Catalog number: 202646-80-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H23N5O
Molecular Weight:
385.46
COA:
Inquire
Targets:
Adenosine Receptor
Description:
FR-194921 is a potent, selective and orally active antagonist for central adenosine A1 receptors that displays high affinity and selectivity for the adenosine A1 receptor (Ki= 2.9 nM) and did not show species differences in binding affinity.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
2-(1-methylpiperidin-4-yl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3-one; FR-194921; FR 194921; FR194921; 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-3(2H)-pyridazinone
MSDS:
Inquire
InChIKey:
YHDRUTMZCJZJAL-UHFFFAOYSA-N
InChI:
1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3
Canonical SMILES:
CN1CCC(CC1)N2C(=O)C=CC(=N2)C3=C4C=CC=CN4N=C3C5=CC=CC=C5
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adenosine Receptor Products


CAS 155271-17-3 KF21213

KF21213
(CAS: 155271-17-3)

KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 n...

XAC

XAC is an adenosine receptor antagonist (IC50 = 1.8 and 114 nM at A1 and A2 receptors, respectively). XAC inhibits adenosine-induced vasodilation and exhibits p...

CAS 280570-45-8 VUF 5574

VUF 5574
(CAS: 280570-45-8)

VUF 5574 is a potent and competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM) that displays ≥ 2500-fold selectivity over A1 and A2A receptors.

CAS 2122196-16-9 PSB 0777 ammonium salt

PSB 0777 ammonium salt
(CAS: 2122196-16-9)

PSB 0777 is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors), with subtype selectivity for A2A receptors over A1...

CVT5440
(CAS: 531506-64-6)

CVT5440 is a selective, high affinity A(2B) adenosine receptor antagonist. It may has the potential treatment of asthma and has good selectivity.

CAS 155270-99-8 Istradefylline

Istradefylline
(CAS: 155270-99-8)

A very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM)

CAS 161167-65-3 Rolofylline metabolite M1-cis

Rolofylline metabolite M1-cis
(CAS: 161167-65-3)

Rolofylline metabolite M1-cis, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist.

CAS 28128-33-8 8-Aminoadenine

8-Aminoadenine
(CAS: 28128-33-8)

8-Aminoadenine is an adenine receptor agonist with Ki value of 0.0341 μM in HEK293 cells expressing an adenine binding site. It shows 190-fold increased potency...

CAS 53296-10-9 CV 1808

CV 1808
(CAS: 53296-10-9)

CV 1808 has been found to be an adenosine A2 receptor agonist and could probably be used as an antihypertensive as well as antipsychotic agent.

CAS 1246018-36-9 ST4206

ST4206
(CAS: 1246018-36-9)

ST4206 is a potent adenosine A2A antagonist. ST4206 showed neuroprotective effects against rotenone induced alterations instriatal slice preparations,supporting...

FR-194921
(CAS: 202646-80-8)

FR-194921 is a potent, selective and orally active antagonist for central adenosine A1 receptors that displays high affinity and selectivity for the adenosine A...

CAS 160943-06-6 Rolofylline metabolite M1-trans

Rolofylline metabolite M1-trans
(CAS: 160943-06-6)

Rolofylline metabolite M1-trans, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist.

CAS 192053-05-7 MRS 1334

MRS 1334
(CAS: 192053-05-7)

MRS 1334 is a potent and highly specific antagonist for the human adenosine A3 receptor (Ki= are 2.69 nM at hA3).

CAS 36396-99-3 N6-Cyclohexyladenosine

N6-Cyclohexyladenosine
(CAS: 36396-99-3)

N6-Cyclohexyladenosine is a derivative of Adenosine, a selective A1 receptor agonist with EC50 = 8.2 nM.

CAS 121241-87-0 N-0861 racemate

N-0861 racemate
(CAS: 121241-87-0)

N-0861 racemate is the racemate of N-0861 which appears to be an effective and selective A1 adenosine receptor antagonist in humans.

Neladenoson dalanate
(CAS: 1239309-58-0)

Neladenoson dalanate is a potent adenosine A1 receptor agonist originated by Bayer HealthCare Pharmaceuticals. It is applicated for the treatment of Chronic hea...

CAS 103626-26-2 (±)-5'-Chloro-5'-deoxy-ENBA

(±)-5'-Chloro-5'-deoxy-ENBA
(CAS: 103626-26-2)

(±)-5'-Chloro-5'-deoxy-ENBA is a selective adenosine A1 receptor agonist (Ki = 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). It i...

CAS 152918-18-8 CF-101

CF-101
(CAS: 152918-18-8)

CF101 is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models...

CAS 137862-53-4 Valsartan

Valsartan
(CAS: 137862-53-4)

Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

CAS 28822-58-4 IBMX

IBMX
(CAS: 28822-58-4)

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading...

Quick Inquiry

Verification code

Featured Items