FR 171113 - CAS 173904-50-2
Category: Inhibitor
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Molecular Formula:
C19H11Cl3N2O4S
Molecular Weight:
469.73
COA:
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Targets:
Protease-Activated Receptors (PARs)
Description:
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist displaying significant antiplatelet activity in vitro. It inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.
Brife Description:
PAR1 antagonist
Purity:
≥98% by HPLC
Synonyms:
FR 171113; FR171113; FR-171113; 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
MSDS:
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InChIKey:
SDGLYCKTPKZBGI-DALCUZTNSA-N
InChI:
InChI=1S/C19H11Cl3N2O4S/c1-28-16(25)9-15-18(27)24(12-5-2-10(20)3-6-12)19(29-15)23-17(26)13-7-4-11(21)8-14(13)22/h2-9H,1H3/b15-9+,23-19?
Canonical SMILES:
COC(=O)C=C1C(=O)N(C(=NC(=O)C2=C(C=C(C=C2)Cl)Cl)S1)C3=CC=C(C=C3)Cl
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