|Description||FR-122047 is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 values is 0.028μM for COX-1 and 65 μM for COX-2. FR-122047 displays 2300 fold greater selectivity towards inhibition of COX-1 over COX-2. It shows analgesic, anti-platelet and anti-inflammatory properties. No development was reported for the treatment of Pain, Rheumatoid arthritis and Thrombosis.|
|Appearance||Pale yellow solid|
|Synonyms||FR 122047 hydrochloride;1-[[4,5-bis-(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride|
|Solubility||water to 10 mM 1eq. HCl to 5 mM DMSO to 100 mM ethanol to 25 mM|
|Application||Pain; Rheumatoid arthritis; Thrombosis|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator Fujisawa|
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FR 122047 hydrochloride
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