|Description||This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma in Japan.|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator: Fujisawa|
This active molecular is a Leukotriene B4 antagonist. PD- 127443 is also a 5-lipoxygenase and cyclooxygenase inhibitor and it has been reported to have antiinfl...
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) (IC50= 0.28 μM) and also an inhibitor of 5-lipoxygenase (IC50= 1.05 μM).
CMI-392 is a dual antagonist of 5-lipoxygenese (IC50= 100 nM) and platelet-activating factor (PAF) receptor (IC50= 10 nM).
A dual inhibitor of cylooxygenase and 5-lipoxygenase
ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
Enazadrem phosphate is a 5-lipoxygenase inhibitor as an Antipsoriatic agent.
Zileuton sodium is an inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes(LTB4, LTC4, LTD4 and LTE4) formation with an IC50 value of 0.5μM. Zileuton sod...
Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.
ICI 211965 is a selective 5-lipoxygenase inhibitor and it may be useful in regulating production of those interleukins involved in joint cartilage destruction.
LY 269415 is a 5-Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties in vitro. But no development was re...
PF04191834 is a novel, potent and selective non-redox 5-lipoxygenase(5-LOX) inhibitor with an IC50 value of 229 +/- 20 nM. It inhibits 5-LOX in human blood cell...
Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms o...
This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma ...
A topically effective inhibitor of 5-lipoxygenase (5-LO)
Tenidap is one of the nonsteroidal antiinflammatory drugs. It is a COX1/2 and 5-lipoxygenase inhibitor. Tenidap preferentially inhibits COX-1 and IC50 value is...