Forsythoside E - CAS 93675-88-8
Catalog number: 93675-88-8
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Molecular Formula:
Chemical Family:
2-(3,4-Dihydroxyphenyl)Ethyl 6-O-(6-Deoxy-Alpha-L-Mannopyranosyl)-Beta-D-Glucopyranoside
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1.New phenylethanoid glycosides from the fruits of forsythia suspense (thunb.) vahl.
Wang FN;Ma ZQ;Liu Y;Guo YZ;Gu ZW Molecules. 2009 Mar 25;14(3):1324-31. doi: 10.3390/molecules14031324.
Forsythosides H-J (1-3), three new caffeoyl phenylethanoid glycosides (CPGs), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl., together with six known phenylethanoid glycosides: Forsythoside A (4), Forsythoside F (5), Forsythoside E (6), 2-(3,4-dihydroxyphenyl)ethyl-beta-D-glucopyranoside (7), phenethyl alcohol beta-D-xylo-pyranosyl-(1-->6)-beta-D-glucopyranoside (8) and calceolarioside B (9). Their structures were determined by spectroscopic and chemical methods.
2.Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus.
Bao J;Ding RB;Liang Y;Liu F;Wang K;Jia X;Zhang C;Chen M;Li P;Su H;Wan JB;Wang Y;He C Am J Chin Med. 2017;45(7):1513-1536. doi: 10.1142/S0192415X17500823. Epub 2017 Sep 25.
Forsythiae Fructus, Lianqiao in Chinese, is one of the most fundamental herbs in Traditional Chinese Medicine. Both green Forsythia (GF) and ripe Forsythia (RF) are referred to Forsythiae Fructus in medicinal applications. In most cases, they are used without distinction. In this study, a metabolomics approach was performed to compare componential differences of two Forsythiae Fructus aqueous extracts subtypes. Principal component analysis (PCA) score plots from the UPLC-MS data showed clear separation between the two subtypes, indicating there are significant differences in the chemical components between GF and RF. Meanwhile, the anticancer activity of them was also compared. GF exhibited much stronger antitumor activity than RF against B16-F10 murine melanoma both in vitro and in vivo. 15 chemical compounds were identified as specific markers for distinguishing GF and RF. Among these marker compounds, forsythoside I, forsythoside A, forsythoside E and pinoresinol were demonstrated to be key important active compounds that account for the different anticancer efficacies of GF and RF. Our data suggest that GF and RF should be distinctively used in clinical applications, particularly in the anticancer formulas, in which GF should be preferentially prescribed.
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Chemical Structure

CAS 93675-88-8 Forsythoside E

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