Formononetin - CAS 485-72-3
Catalog number: 485-72-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H12O4
Molecular Weight:
268.26
COA:
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Targets:
Others
Description:
Formononetin is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
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Purity:
>98%
Synonyms:
Formononetol, Biochanin B
MSDS:
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1.Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression.
Guo YH1, Wang Y1, Xin M1. Pharm Biol. 2016 Feb 26:1-6. [Epub ahead of print]
Context Formononetin is a typical phytoestrogen, which is a bioactive component found in red clover plants. Previous studies have shown that formononetin inhibits the proliferation of several types of cancer cells, including prostate cancer and osteosarcoma. However, how formononetin affects the proliferation of CNE2 is not clear. Objective The objective of this study is to investigate the effects of formononetin on nasopharyngeal carcinoma cells in vitro, along with the underlying mechanism. Materials and methods CNE2 cells were incubated with various concentrations of formononetin (0, 0.1, 0.2, 0.3 and 1 μM) for 48 h. Cell proliferation was measured by [3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay, while the rate of apoptosis was measured by flow cytometry. Bcl-2 and bax mRNA expression levels were determined by real time polymerase chain reaction (RT-PCR), while p-ERK1/2 and bcl-2 protein expression levels were quantified by Western blotting.
2.Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression.
Guo YH1, Wang Y1, Xin M1. Pharm Biol. 2016 Feb 26:1-6. [Epub ahead of print]
Context Formononetin is a typical phytoestrogen, which is a bioactive component found in red clover plants. Previous studies have shown that formononetin inhibits the proliferation of several types of cancer cells, including prostate cancer and osteosarcoma. However, how formononetin affects the proliferation of CNE2 is not clear. Objective The objective of this study is to investigate the effects of formononetin on nasopharyngeal carcinoma cells in vitro, along with the underlying mechanism. Materials and methods CNE2 cells were incubated with various concentrations of formononetin (0, 0.1, 0.2, 0.3 and 1 μM) for 48 h. Cell proliferation was measured by [3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay, while the rate of apoptosis was measured by flow cytometry. Bcl-2 and bax mRNA expression levels were determined by real time polymerase chain reaction (RT-PCR), while p-ERK1/2 and bcl-2 protein expression levels were quantified by Western blotting.
3.Methoxyisoflavones formononetin and isoformononetin inhibit the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.
Mansoori MN1, Tyagi AM, Shukla P, Srivastava K, Dev K, Chillara R, Maurya R, Singh D. Menopause. 2016 May;23(5):565-76. doi: 10.1097/GME.0000000000000646.
OBJECTIVE: Recent studies have shown that immune system plays a major role in pathophysiology of postmenopausal osteoporosis. Previously we have shown that phytoestrogens like daidzein and medicarpin exhibit immunoprotective effects, by virtue of which they alleviate bone loss. With this background, methoxyisoflavones like formononetin (formo) and isoformononetin (isoformo) that have been studied for preventing bone loss in ovariectomized rats were tested for their immunomodulatory effects in estrogen-deficient bone loss mice model.
4.Plasma isoflavones in Malaysian men according to vegetarianism and by age.
Hod R1, Kouidhi W2, Mohd MA3, Husain R4. Asia Pac J Clin Nutr. 2016 Mar;25(1):89-96. doi: 10.6133/apjcn.2016.25.1.02.
in English, Chinese流行病学研究表明东南亚乳腺癌、前列腺癌和心血管疾病的发病率较低,素食 在这些地区备受欢迎,传统饮食中富含植物雌激素。本研究根据年龄评估了马 来西亚素食和非素食男性血浆中异黄酮的含量。通过高效液相色谱-串联质谱 法(LCMSMS)测定血浆中大豆异黄酮、染料木素、雌马酚(一种大豆异黄 酮的代谢产物)、芒柄花素、鹰嘴豆芽素A、雌酮、雌二醇和睾酮的浓度。按 照年龄(18-34 岁、35-44 岁和45-67 岁)测定了225 名研究对象的血浆异黄酮 和性激素的浓度。在所有年龄组,尤其是45-67 岁组,素食者循环异黄酮浓度 高于非素食者,在45-67 岁组,除雌马酚外的所有异黄酮,素食者均显著高于 杂食者。相反,在18-34 岁组,素食者的大豆异黄酮、睾酮和雌酮的浓度显著 高于非素食者。在这个年龄组中,雌酮、雌二醇和睾酮与一些异黄酮之间有弱 的相关性。本研究提供了马来西亚素食和非素食男性植物雌激素状态的第一手 资料。.
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CAS 485-72-3 Formononetin

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