Formononetin - CAS 485-72-3
Catalog number: 485-72-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H12O4
Molecular Weight:
268.26
COA:
Inquire
Targets:
Others
Description:
Formononetin is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Formononetol, Biochanin B
MSDS:
Inquire
1.Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression.
Guo YH1, Wang Y1, Xin M1. Pharm Biol. 2016 Feb 26:1-6. [Epub ahead of print]
Context Formononetin is a typical phytoestrogen, which is a bioactive component found in red clover plants. Previous studies have shown that formononetin inhibits the proliferation of several types of cancer cells, including prostate cancer and osteosarcoma. However, how formononetin affects the proliferation of CNE2 is not clear. Objective The objective of this study is to investigate the effects of formononetin on nasopharyngeal carcinoma cells in vitro, along with the underlying mechanism. Materials and methods CNE2 cells were incubated with various concentrations of formononetin (0, 0.1, 0.2, 0.3 and 1 μM) for 48 h. Cell proliferation was measured by [3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay, while the rate of apoptosis was measured by flow cytometry. Bcl-2 and bax mRNA expression levels were determined by real time polymerase chain reaction (RT-PCR), while p-ERK1/2 and bcl-2 protein expression levels were quantified by Western blotting.
2.Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression.
Guo YH1, Wang Y1, Xin M1. Pharm Biol. 2016 Feb 26:1-6. [Epub ahead of print]
Context Formononetin is a typical phytoestrogen, which is a bioactive component found in red clover plants. Previous studies have shown that formononetin inhibits the proliferation of several types of cancer cells, including prostate cancer and osteosarcoma. However, how formononetin affects the proliferation of CNE2 is not clear. Objective The objective of this study is to investigate the effects of formononetin on nasopharyngeal carcinoma cells in vitro, along with the underlying mechanism. Materials and methods CNE2 cells were incubated with various concentrations of formononetin (0, 0.1, 0.2, 0.3 and 1 μM) for 48 h. Cell proliferation was measured by [3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay, while the rate of apoptosis was measured by flow cytometry. Bcl-2 and bax mRNA expression levels were determined by real time polymerase chain reaction (RT-PCR), while p-ERK1/2 and bcl-2 protein expression levels were quantified by Western blotting.
3.Methoxyisoflavones formononetin and isoformononetin inhibit the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.
Mansoori MN1, Tyagi AM, Shukla P, Srivastava K, Dev K, Chillara R, Maurya R, Singh D. Menopause. 2016 May;23(5):565-76. doi: 10.1097/GME.0000000000000646.
OBJECTIVE: Recent studies have shown that immune system plays a major role in pathophysiology of postmenopausal osteoporosis. Previously we have shown that phytoestrogens like daidzein and medicarpin exhibit immunoprotective effects, by virtue of which they alleviate bone loss. With this background, methoxyisoflavones like formononetin (formo) and isoformononetin (isoformo) that have been studied for preventing bone loss in ovariectomized rats were tested for their immunomodulatory effects in estrogen-deficient bone loss mice model.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1021-11-0 Guanoxyfen sulfate

Guanoxyfen sulfate
(CAS: 1021-11-0)

Guanoxyfen sulfate is an inhibitor of vasoconstrictor responses to sympathetic nerve stimulation. It could potentiate the actions of adrenaline and noradrenalin...

ITX-5061
(CAS: 848144-15-0)

ITX-5061 is a scavenger receptor B1 antagonist. Preclinical studies show that ITX-5061 is a selective inhibitor of HCV entry into hepatocytes. It can prevent vi...

CAS 843782-19-4 Neuromedin S (rat)

Neuromedin S (rat)
(CAS: 843782-19-4)

Neuromedin S, a novel neuropeptide of 36 amino acids isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and F...

Ciraparantag
(CAS: 1438492-26-2)

Ciraparantag, also called as PER977, a synthetic, cationic small molecule, has potential to be a simple, inexpensive universal anticoagulation reversal agent.

CAS 353519-63-8 HLM006474

HLM006474
(CAS: 353519-63-8)

HLM 006474 acts as an E2F transcription factor inhibitor, preventing DNA binding activity. This results in the induction of apoptosis in breast cancer cells.

CAS 1354359-53-7 JW 480

JW 480
(CAS: 1354359-53-7)

JW 480 has been found to be a potent and selective inhibitor of KIAA1363 (AADACL1), which is a kind of serine hydrolase enzyme.

CAS 290821-39-5 Cimiracemoside D

Cimiracemoside D
(CAS: 290821-39-5)

Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.

CAS 915365-57-0 Cot inhibitor-1

Cot inhibitor-1
(CAS: 915365-57-0)

Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Epithalon
(CAS: 307297-39-8)

Epithalon is a synthetic tetra-peptide used to regulate the cell cycle through up-regulation of telomerase activity showing anticancer and anti-tumor metastati...

CAS 151988-33-9 Ac2-26

Ac2-26
(CAS: 151988-33-9)

Ac2-26 is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothe...

CAS 73334-07-3 Iopromide

Iopromide
(CAS: 73334-07-3)

Iopromide is a contrast medium produced by Bayer Healthcare. It is a low osmolar, non-ionic contrast agent for intravascular use. It can be used in radiographic...

CAS 538-71-6 Domiphen Bromide

Domiphen Bromide
(CAS: 538-71-6)

Domiphen bromide is a quaternary ammonium antiseptic with actions as a cationic surfactant.

CAS 477-90-7 Bergenin

Bergenin
(CAS: 477-90-7)

Bergenin is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.It shows a potent immunomodulatory effect.

CAS 41964-07-2 MLR 1023

MLR 1023
(CAS: 41964-07-2)

Tolimidone is an allosteric Lyn kinase activator with EC50 value of 63 nM. It has been shown to reduce blood glucose levels in mice.

CAS 16200-50-3 PYR-0503

PYR-0503
(CAS: 16200-50-3)

PYR-0503, a pyrrole compound, could be commonly used in production of sorts of important compounds like some anticancer drugs and porphyrins.

CAS 79756-69-7 TPI-1

TPI-1
(CAS: 79756-69-7)

TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulate...

MK-B 251
(CAS: 40396-69-8)

MK-B 251 is a synthetic bio-active chemical.

CAS 129639-79-8 abafungin

abafungin
(CAS: 129639-79-8)

Abafungin is a broad-spectrum antifungal agent with a novel mechanism of action originated by York Pharma. In Aug 2009, Phase-III for Dermatomycoses in Japan an...

CAS 121-32-4 Ethyl vanillin

Ethyl vanillin
(CAS: 121-32-4)

Ethyl vanillin, a kind of flavorant, could be commonly used in the production of food like chocolate. FEMA No: 2464.

CB 3731
(CAS: 80015-07-2)

CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase.

Chemical Structure

CAS 485-72-3 Formononetin

Quick Inquiry

Verification code

Featured Items