Fonazine - CAS 7456-24-8
Catalog number: 7456-24-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H25N3O2S2
Molecular Weight:
391.55
COA:
Inquire
Targets:
Histamine Receptor
Description:
Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine.
Purity:
98%
Appearance:
Powder
Synonyms:
Fonazine; Dimetotiazine; Dimethothiazine; Dimetiotazine; Banistyl; Dimethodin; fonazine mesylate; fonazine monomesylate ;Migristene; Promaquid;10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide;7455-39-2(Dimetotiazine Mesilate)
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
migraine
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
VWNWVCJGUMZDIU-UHFFFAOYSA-N
InChI:
1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
Canonical SMILES:
CC(CN1c2ccccc2Sc3c1cc(cc3)S(=O)(=O)N(C)C)N(C)C
1.Effects of KB-2796 on plasma extravasation following antidromic trigeminal stimulation in the rat.
Hashimoto M;Yamamoto Y;Takagi H Res Commun Mol Pathol Pharmacol. 1997 Jul;97(1):79-94.
We investigated the effects of KB-2796 (1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride), a novel calcium channel blocker, on neurogenic inflammation caused by electrical stimulation in the trigeminal ganglion and on cutaneous reactions induced by inflammatory mediators in rats, by measuring plasma extravasation. Neurogenic inflammation was inhibited by pretreatment with capsaicin (25 mg/kg, s.c.) but not indomethacin (10 mg/kg, i.p.), while phosphoramidon (2.5 mg/kg, i.v.) augmented it. KB-2796 (0.1-1 mg/kg, i.v.) significantly inhibited neurogenic inflammation in a dose dependent manner, without affecting histamine-, bradykinin- or substance P-induced cutaneous reactions. Dimetotiazine (0.3 and 1 mg/kg, i.v.), flunarizine (1 mg/kg, i.v.), mepyramine (1 mg/kg, i.v.) and sumatriptan (1 mg/kg, i.v.) significantly inhibited neurogenic inflammation. However, these compounds also showed complete or partial inhibition of histamine-, bradykinin- or substance P-induced reactions. Nifedipine (0.1 mg/kg, i.v.) did not show marked effects on neurogenic inflammation and cutaneous reactions. The present experiments indicate that neurogenic inflammation is presumably mediated not only by neuropeptides released from trigeminal nerve endings but also by secondarily released histamine, and that KB-2796 like sumatriptan may inhibit neurogenic inflammation caused by trigeminal nerve stimulation probably through inhibition of neuropeptide release but its inhibition may be distinct from the calcium blocking action of the 1,4-dihydropyridine type.
2.Enhancement of the cyclic motor activity of the ovine small intestine by lysergic acid derivatives. Mechanism and significance.
Ruckebusch Y Gastroenterology. 1984 Nov;87(5):1049-55.
The effects of a variety of substances influencing the initiation of cyclic motor events at the gastroduodenal junction were studied in conscious sheep. A significant and long-lasting decrease in the frequency of cyclic events from approximately 100 min to 30-40 min was elicited by the intraduodenal bulb administration of the lysergic acid derivatives methylergonovine and methysergide. This effect was dose-dependent and occurred with smaller dosages than those effective when administered parenterally or more distal in the jejunum. Intraluminal administration of cyproheptadine, fonazine, and metergoline into the duodenal bulb increased the interval between phase III activity. At higher dosages, however, cyproheptadine and metergoline reduced the spiking activity of the antroduodenal junction, without significantly changing the cycle duration of the migrating myoelectric complex on the duodenal bulb or jejunum. After administration of cyproheptadine, fonazine, and metergoline, the cycling activity of the duodenojejunum was irregular for 1-2 days. These findings are compatible with a resetting of the enteric biological clock at a faster rhythm and suggest a selective action via an enteric serotoninergic mechanism involved in the normal pacing of the cyclic motor events of the gut.
3.Comparative effects of selected phenothiazine tranquilizers and antihistaminics on bacterial cells and possible interactions with antibiotics.
Shibl AM;Hammouda Y;Al-Sowaygh I J Pharm Sci. 1984 Jun;73(6):841-3.
Evaluation of the antibacterial effect of phenothiazine antihistaminics (trimeprazine, promethazine, and fonazine) and phenothiazine tranquilizers (promazine, chlorpromazine, triflupromazine, and propiomazine) on Staphylococcus aureus showed that tranquilizers were more active [minimum inhibitory concentration (MIC) 0.5-1.6 micrograms/mL] than antihistaminics (MIC greater than 1.6 micrograms/mL). The antibacterial activity was found to correlate with both the rate of adsorption of these drugs on the bacterial cells and the surface tension of their solutions. Phenothiazine tranquilizers caused rapid and extensive leakage of potassium ions from bacterial cells, while phenothiazine antihistaminics produced relatively slower leakage of these ions. A study of the effect of the phenothiazines on the antibacterial activity of some antibiotics showed that all phenothiazines produced a synergistic effect with erythromycin and an antagonistic effect with tobramycin. Variable effects were observed with chloramphenicol, and no effect was observed with penicillin. Results were explained on the basis of structural characteristics of the phenothiazines.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products


CAS 1082954-71-9 A 987306

A 987306
(CAS: 1082954-71-9)

A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selecti...

CAS 195867-54-0 HTMT dimaleate

HTMT dimaleate
(CAS: 195867-54-0)

HTMT dimaleate is a histamine H1 and H2 receptor agonist with 4x104 fold activity over histamine in H2-mediated effects in natural suppressor cells. HTMT dimale...

CAS 720690-73-3 GSK 189254A

GSK 189254A
(CAS: 720690-73-3)

GSK-189,254 is a H3 histamine receptor inverse agonist. It has subnanomolar affinity for the H3 receptor with Ki of 0.2nM. It possesses stimulant and nootropic ...

CAS 32385-58-3 Imetit dihydrobromide

Imetit dihydrobromide
(CAS: 32385-58-3)

Imetit dihydrobromide is a potent and high affinity agonist at histamine H3 and H4 receptors (Ki = 0.3 and 2.7 nM, respectively). It induces an eosinophil shape...

CAS 10246-75-0 Hydroxyzine pamoate

Hydroxyzine pamoate
(CAS: 10246-75-0)

Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probab...

CAS 23256-33-9 Dimaprit dihydrochloride

Dimaprit dihydrochloride
(CAS: 23256-33-9)

The hydrochloride salt form of Dimaprit, which has been found to be a histamine H2 receptor agonist.

CAS 1163-36-6 Clemizole hydrochloride

Clemizole hydrochloride
(CAS: 1163-36-6)

The hydrochloride salt form of clemizole, which is a histamine H1 antagonist with antitumor activity. It also has hepatitis C antiviral effect through restraini...

CAS 5638-76-6 Betahistine

Betahistine
(CAS: 5638-76-6)

Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma...

Chemical Structure

CAS 7456-24-8 Fonazine

Quick Inquiry

Verification code

Featured Items