Fluvoxamine maleate - CAS 61718-82-9
Catalog number: B0084-073281
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and sigma-1 receptor agonist.
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B0084-073281 5 g $238 In stock
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Related CAS:
54739-18-3 (free base)
White Solid
(E)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate; DU-23000; MK-264; Dumirox; Faverin; Fevarin; Floxyfral; Luvox; Maveral
Store at -20°C
Melting Point:
Canonical SMILES:
1.The effects of fluvoxamine on the steady-state plasma concentrations of escitalopram and desmethylescitalopram in depressed Japanese patients.
Yasui-Furukori N1, Tsuchimine S, Kubo K, Ishioka M, Nakamura K, Inoue Y. Ther Drug Monit. 2016 Mar 21. [Epub ahead of print]
BACKGROUND: The aim of this study was to determine the impact of fluvoxamine, an inhibitor of CYP2C19, on the pharmacokinetics of escitalopram, a substrate of CYP2C19.
2.A Review of Pharmacologic Treatment for Compulsive Buying Disorder.
Soares C1, Fernandes N2, Morgado P2,3,4. CNS Drugs. 2016 Apr 11. [Epub ahead of print]
At present, no treatment recommendations can be made for compulsive buying disorder. Recent studies have found evidence for the efficacy of psychotherapeutic options, but less is known regarding the best pharmacologic treatment. The purpose of this review is to present and analyze the available published evidence on the pharmacological treatment of compulsive buying disorder. To achieve this, we conducted a review of studies focusing on the pharmacological treatment of compulsive buying by searching the PubMed/MEDLINE database. Selection criteria were applied, and 21 studies were identified. Pharmacological classes reported included antidepressants, mood stabilizers, opioid antagonists, second-generation antipsychotics, and N-methyl-D-aspartate receptor antagonists. We found only placebo-controlled trials for fluvoxamine; none showed effectiveness against placebo. Three open-label trials reported clinical improvement with citalopram; one was followed by a double-blind discontinuation.
3.Yokukansan improves behavioral and psychological symptoms of dementia by suppressing dopaminergic function.
Takeyoshi K1, Kurita M2, Nishino S3, Teranishi M4, Numata Y5, Sato T5, Okubo Y4. Neuropsychiatr Dis Treat. 2016 Mar 15;12:641-9. doi: 10.2147/NDT.S99032. eCollection 2016.
Although three drugs, risperidone, yokukansan, and fluvoxamine, have shown equal efficacy in treating behavioral and psychological symptoms of dementia (BPSD) in our previous study, their mechanisms of action are different from one another. Monoamines have attracted attention for their key roles in mediating several behavioral symptoms or psychological symptoms through synaptic signaling. We aimed to clarify the monoamines changed by treatment with each drug in patients with BPSD. The main purpose of this study was to determine whether plasma levels of catecholamine metabolites are correlated with pharmacological treatments. This was an 8-week, rater-blinded, randomized, flexible-dose, triple-group trial. In total, 90 subjects were recruited and subsequently three different drugs were allocated to 82 inpatients with BPSD. We examined BPSD data from patients who completed 8 weeks of treatment. Eventually, we analyzed 42 patients (yokukansan: 17; risperidone: 9; fluvoxamine: 16).
4.Serotonin syndrome presenting as pulmonary edema.
Shah ND1, Jain AB2. Indian J Pharmacol. 2016 Jan-Feb;48(1):93-5. doi: 10.4103/0253-7613.174575.
Serotonin syndrome (SS) is a potentially life-threatening condition resulting from excessive central and peripheral serotonergic activity. Clinically, it is a triad of mental-status changes, neuromuscular abnormalities, and autonomic disturbances. It can be caused by intentional self-poisoning, overdose, or inadvertent drug interactions. We report the case of a 58-year-old male with type 2 diabetes mellitus and obsessive compulsive disorder who developed pulmonary edema as a possible complication of SS. SS was caused by a combination of three specific serotonin re-uptake inhibitors (fluoxetine, fluvoxamine, and sertraline), linezolid, and fentanyl. The hospital course was further complicated by difficult weaning from the ventilator. SS was identified and successfully treated with cyproheptadine and lorazepam. The case highlights the importance of effective consultation-liaison and prompt recognition of SS as the presentation may be complex in the presence of co-morbid medical illness.
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CAS 61718-82-9 Fluvoxamine maleate

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