|Targets||HMG-CoA Reductase (HMGCR)|
|Description||Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR) with IC50 of 8 nM. It belongs to a class of the statin drug and is structurally distinct from the fungal derivatives of this therapeutic class. It binds of the substrate HMG-CoA with Ki value of 0.3 nM but not with respect to binding of NADPH. It is marketed under the trade name Lescol® and is used to treat hypercholesterolemia and to prevent cardiovascular disease. It induces G2/M phase arrest and has antilipemic effect.|
|Synonyms||XU-62320; XU 62320; XU62320; Cranoc;Lescol;(+)-(3R,5S)-fluvastati;(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid;6-Heptenoic acid,7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,[R*,S*-(E)]-|
|Solubility||10 mM in DMSO|
|Application||Fluvastatin is used to treat hypercholesterolemia and to prevent cardiovascular disease. It has antilipemic effect.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Kilogram to ton|
|Boiling Point||681.8±55.0 °C | Condition: Press: 760 Torr|
|Melting Point||193.9-196.9 °C|
|Density||1.23±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
Atorvastatin, a HMG-CoA reductase inhibitor, could be used to reduce cholesterol and prevent cardiovascular related disease.
Meglutol is a hypolipidemic agent which inhibits the activity of hydroxymethylglutarryl CoA reductases.
Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase dep...
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
Pitavastatin calcium is a novel member of the medication class of statins.
Pravastatin is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase with IC...
Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR) with IC50 of 8 nM. It belongs to a class of the statin drug and is ...