Fluticasone propionate - CAS 80474-14-2
Catalog number: B0084-301395
Category: Inhibitor
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Molecular Formula:
C25H31F3O5S
Molecular Weight:
500.57
COA:
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Targets:
Glucocorticoid Receptor
Description:
Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-301395 100 mg $390 In stock
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Brife Description:
corticosteroid, asthma and allergic rhinitis
Purity:
>98%
Synonyms:
Fluticasone Propionate, Cutivate, Flixonase, Flixotide, Flonase, Flovent; DSSTox_CID_25511; DSSTox_RID_80922; DSSTox_GSID_45511; NCGC00016943-01
Solubility:
Water: 0.51 mg/L
MSDS:
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Application:
the treatment of asthma and allergic rhinitis
Melting Point:
272-273 °C
InChIKey:
WMWTYOKRWGGJOA-ZHLGSTKJSA-N
InChI:
InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16?,18+,19+,22+,23+,24+,25+/m1/s1
Canonical SMILES:
CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
1.Oral Low-Dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients with Severe COPD: A Pilot Clinical Trial.
Cosío BG, Shafiek H, Iglesias A, Yanez A, Cordova R, Palou A, Rodriguez-Roisin R, Peces-Barba G, Pascual S, Gea J, Sibila O, Barnes PJ, Agusti A. Chest. 2016 Apr 20. pii: S0012-3692(16)48561-2. doi: 10.1016/j.chest.2016.04.011. [Epub ahead of print]
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation. In vitro and ex-vivo observations suggest that this inflammatory response is partially resistant to the effect of corticosteroids, and that low-dose theophylline can restore this response via enhancement of histone deacetylase activity (HDAC). Whether or not this occurs in vivo, and what are its potential clinical consequences is unclear.
2.[Efficacy of fluticasone propionate aerosol versus budesonide suspension in treatment of recurrent wheezing caused by bronchiolitis].
Lan WP1, Wang J, Dai CL, Pan JH. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Apr;18(4):316-9.
OBJECTIVE: To investigate the efficacy of fluticasone propionate aerosol (flixotide) versus budesonide suspension in the treatment of recurrent wheezing caused by bronchiolitis.
3.Long-Term Fluticasone Propionate/Formoterol Fumarate Combination Therapy Is Associated with a Low Incidence of Severe Asthma Exacerbations.
Papi A1, Mansur AH2, Pertseva T3, Kaiser K4, McIver T5, Grothe B6, Dissanayake S6. J Aerosol Med Pulm Drug Deliv. 2016 Apr 22. [Epub ahead of print]
BACKGROUND: A primary goal of asthma management is the reduction of exacerbation risk. We assessed the occurrence of oral corticosteroid-requiring exacerbations (OCS exacerbations) with long-term fluticasone/formoterol therapy, and compared it with the occurrence of similar events reported with other inhaled corticosteroid/long acting β2-agonist (ICS/LABA) combinations.
4.Once-daily fluticasone furoate and vilanterol for adolescents and adults with symptomatic asthma: A systematic review with meta-analysis.
Rodrigo GJ1, Plaza V2. Ann Allergy Asthma Immunol. 2016 Apr 22. pii: S1081-1206(16)30096-5. doi: 10.1016/j.anai.2016.03.035. [Epub ahead of print]
BACKGROUND: Fluticasone furoate and vilanterol is a new inhaled corticosteroid (ICS) and long-acting β2-agonist (LABA) combination developed for once-daily administration via a dry powder inhaler.
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CAS 80474-14-2 Fluticasone propionate

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