Fluticasone furoate - CAS 397864-44-7
Catalog number: B0084-475694
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C27H29F3O6S
Molecular Weight:
538.59
COA:
Inquire
Targets:
Glucocorticoid Receptor
Description:
Fluticasone furoate is a synthetic corticosteroid derived from fluticasone as a selective high affinity glucocorticoid agonist, MRP4 inhibitor;
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-475694 50 mg $998 In stock
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Purity:
≥98%
Appearance:
White to Off-White Solid
Synonyms:
Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-;Gw 685698x;Unii-js86977wnv;Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbony
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
For treatment of seasonal allergic rhinitis.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Grams-Kilos
Melting Point:
250-252 °C
InChIKey:
XTULMSXFIHGYFS-VLSRWLAYSA-N
InChI:
1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
Canonical SMILES:
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
Current Developer:
GlaxoSmithKline
1.Deposition of intranasal glucocorticoids - preliminary study.
Rapiejko P1, Sosnowski TR2, Sova J3, Jurkiewicz D4. Otolaryngol Pol. 2015 Dec 31;69(6):30-8. doi: 10.5604/00306657.1184545.
INTRODUCTION: Intranasal glucocorticoids are the treatment of choice in the therapy of rhinitis. The differences in efficiency of particular medications proven by therapeutic index may result from differences in composition of particular formulations as well as from diverse deposition in nasal cavities. Intranasal formulations of glucocorticoids differ in volume of a single dose in addition to variety in density, viscosity and dispenser nozzle structure. The aim of this report was to analyze the deposition of most often used intranasal glucocorticoids in the nasal cavity and assessment of the usefulness of a nose model from a 3D printer reflecting anatomical features of a concrete patient.
2.Population pharmacokinetics of inhaled fluticasone furoate and vilanterol in adult and adolescent patients with asthma.
Allen A, Siederer S, Yang S. Int J Clin Pharmacol Ther. 2016 Apr;54(4):269-81. doi: 10.5414/CP202438.
OBJECTIVES: Population pharmacokinetic (PK) methods were used to characterize the PK of fluticasone furoate (FF) and vilanterol (VI) in patients with asthma following once daily inhaled FF/VI and FF and to identify significant covariates that impact the PK.
3.Inhaled corticosteroids and the increased risk of pneumonia: what's new? A 2015 updated review.
Iannella H1, Luna C2, Waterer G3. Ther Adv Respir Dis. 2016 Feb 18. pii: 1753465816630208. [Epub ahead of print]
There is a considerable amount of evidence that supports the possibility of an increased risk of pneumonia associated with prolonged use of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD). However, as yet, no statistically significant increase in pneumonia-related 30-day mortality in patients on ICS has been demonstrated. The lack of objective pneumonia definitions and radiological confirmations have been a major source of bias, because of the similarities in clinical presentation between pneumonia and acute exacerbations of COPD. One of the newer fluticasone furoate studies overcomes these limitations and also provides an assessment of a range of doses, suggesting that the therapeutic window is quite narrow and that conventional dosing has probably been too high, although the absolute risk may be different compared to other drugs. Newer studies were not able to rule out budesonide as responsible for pneumonia, as previous evidence suggested, and there is still need for evidence from head-to-head comparisons in order to better assess possible intra-class differences.
4.Population Pharmacokinetics Modeling of Inhaled Umeclidinium for Adult Patients with Asthma.
Yang S1,2, Lee L3, Pascoe S4. Eur J Drug Metab Pharmacokinet. 2016 Mar 30. [Epub ahead of print]
BACKGROUND: Umeclidinium (UMEC; a long-acting anti-muscarinic) in combination with fluticasone furoate (an inhaled corticosteroid) is in development for asthma treatment. This secondary analysis aimed to develop a population pharmacokinetic model characterizing UMEC in adults with asthma, and evaluated the impact of covariates on pharmacokinetic parameters.
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CAS 397864-44-7 Fluticasone furoate

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