Flutamide - CAS 13311-84-7
Catalog number: 13311-84-7
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Androgen Receptor
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
SCH13521; SCH-13521; SCH 13521; Flucinom; Flugerel; Niftolid; Eulexin; Apimid; Chimax; Drogenil; Euflex; Eulexine; Flucinome; Fluken; Flulem; Flutabene; Flutacan; FlutaGry; Flutamex; Flutamin; Flutan; Flutaplex; Fugerel; Grisetin; Oncosal; Profamid; Prostacur; Prostadirex; Prostica; Prostogenat; Tafenil; Tecnoflut; Testotard. FLUT.
Canonical SMILES:
1.The effects of pH, temperature and protein concentration on the in vitro binding of flutamide to human serum albumin.
Esmaeilzadeh S1,2, Valizadeh H3, Zakeri-Milani P4. Pharm Dev Technol. 2016 Apr 7:1-10. [Epub ahead of print]
Human serum albumin (HSA) is the most abundant protein in plasma with a high ligand-binding capacity. This capacity impacts the pharmacokinetic properties of therapeutic drugs. In the present study, the binding properties of flutamide to HSA at different temperatures, pHs and percentages of HSA were investigated. Thermodynamic parameters were also determined to describe the nature of binding interaction. A modified ultrafiltration method was used for accurate determination of flutamide-HSA parameters. Ultra filtrate samples containing free flutamide were extracted and analyzed by developed HPLC-UV method. Analysis of binding data was performed in terms of Scatchard, Klotz and Hill plots. Kinetic parameters (n, Ka) were found to be affected by temperature, pH and HSA concentration. However, flutamide-HSA-binding level did not show significant differences under different experimental conditions. The negative value of Gibbs free energy (ΔG) indicated that the binding was spontaneous.
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CAS 13311-84-7 Flutamide

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