Flutamide - CAS 13311-84-7
Catalog number:
13311-84-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H11F3N2O3
Molecular Weight:
276.21
COA:
Inquire
Targets:
Androgen Receptor
Description:
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
SCH-13521
MSDS:
Inquire
1.The effects of pH, temperature and protein concentration on the in vitro binding of flutamide to human serum albumin.
Esmaeilzadeh S1,2, Valizadeh H3, Zakeri-Milani P4. Pharm Dev Technol. 2016 Apr 7:1-10. [Epub ahead of print]
Human serum albumin (HSA) is the most abundant protein in plasma with a high ligand-binding capacity. This capacity impacts the pharmacokinetic properties of therapeutic drugs. In the present study, the binding properties of flutamide to HSA at different temperatures, pHs and percentages of HSA were investigated. Thermodynamic parameters were also determined to describe the nature of binding interaction. A modified ultrafiltration method was used for accurate determination of flutamide-HSA parameters. Ultra filtrate samples containing free flutamide were extracted and analyzed by developed HPLC-UV method. Analysis of binding data was performed in terms of Scatchard, Klotz and Hill plots. Kinetic parameters (n, Ka) were found to be affected by temperature, pH and HSA concentration. However, flutamide-HSA-binding level did not show significant differences under different experimental conditions. The negative value of Gibbs free energy (ΔG) indicated that the binding was spontaneous.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Androgen Receptor Products


CAS 19608-29-8 Cortexolone 17 alpha-propionate

Cortexolone 17 alpha-propionate
(CAS: 19608-29-8)

Cortexolone 17 alpha-propionate, also called as CB-03-01, belonging to the family of ester derivatives of cortexolone, is a potent and topical and peripherally ...

CAS 401900-40-1 Andarine

Andarine
(CAS: 401900-40-1)

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs.

LGD-4033 (Ligandrol)
(CAS: 1165910-22-4)

LGD-4033, also known as VK5211 and Ligandrol, is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wast...

CAS 1242137-16-1 N-Desmethyl Enzalutamide

N-Desmethyl Enzalutamide
(CAS: 1242137-16-1)

N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits...

CAS 427-51-0 Cyproterone acetate

Cyproterone acetate
(CAS: 427-51-0)

Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor ago...

CAS 1182367-47-0 RAD140

RAD140
(CAS: 1182367-47-0)

RAD140, an effective non-steroidal selective androgen receptor modulator, could probably stimulate the increasing of muscle and also has been found to have pote...

CAS 915087-33-1 Enzalutamide

Enzalutamide
(CAS: 915087-33-1)

Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM. It inhibits the activity of prostate cancer cell Ars, which over expressed in prostate ...

LGD-2226
(CAS: 328947-93-9)

LGD-2226 is a selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis, shows to have an anabolic effect on muscle and bon...

MI-136
(CAS: 1628316-74-4)

MI-136, with the potential to treat refractory prostate cancer, inhibits DHT-induced expression of androgen receptor (AR) target genes. In vitro: Treatment with...

CAS 52-01-7 Spironolactone

Spironolactone
(CAS: 52-01-7)

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

CAS 34633-34-6 BX341

BX341
(CAS: 34633-34-6)

BX341, also known as bifluranol, is a new fluorinated bibenzyl anti-androgen and one of a series of bibenzyls designed to present some of the hormonal propertie...

GSK-2881078
(CAS: 1539314-06-1)

GSK-2881078, an indole derivative, has been found to be an androgen receptor modulator that could probably be effective against Cachexia. It is still under Phas...

CAS 1240299-33-5 AZD-3514

AZD-3514
(CAS: 1240299-33-5)

AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity. AZD3514 is being evaluated in a Phase I clinical trial in patie...

CAS 60607-35-4 Topterone

Topterone
(CAS: 60607-35-4)

A steroidal antiandrogen drug

BMS-564929
(CAS: 627530-84-1)

BMS-564929 is a novel androgen receptor (AR) modulator (Ki= 2.11 nM) which has been advanced to clinical trials for the treatment of age-related functional decl...

CAS 154992-24-2 RU 58841

RU 58841
(CAS: 154992-24-2)

RU 58841 is a new non-steroidal antiandrogen which has potential for use in treating androgen-dependent skin disorders such as acne, hirsutism and androgen-depe...

CAS 3546-41-6 Pyrvinium pamoate

Pyrvinium pamoate
(CAS: 3546-41-6)

Pyrvinium pamoate, a nonabsorbed anthelmintic drug, is a potent androgen receptor inhibitor and a selective WNT pathway inhibitor. Pyrvinium pamoate is a potent...

CAS 13311-84-7 Flutamide

Flutamide
(CAS: 13311-84-7)

Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer...

CAS 956104-40-8 ARN-509

ARN-509
(CAS: 956104-40-8)

ARN-509, also known as JNJ-56021927, is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby p...

ORM-15341
(CAS: 1297537-33-7)

ORM-15341, an androgen receptor antagonist, could have potential effect against prostate cancer and commonly found as an active main metabolite of ODM-201. IC50...

Chemical Structure

CAS 13311-84-7 Flutamide

Quick Inquiry

Verification code

Featured Items