|Description||Flurizan, also called Tarenflurbil, is a nonsteroidal anti-inflammatory drug which inhibits γ-secretase activity leading to preventing the formation of the amyloid β peptide (Aβ42) from amyloid β precursor protein (APP).|
|Brife Description||Reduces Aβ42 levels (Amyloid-β: IC50 = 280 µM (human); γ-secretase inhibitor|
|Synonyms||(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid; 257-264-7; 501W00OOWA; flurizan; MPC-7869; MPC7869; tarenflurbil; Tarenflurbil; (R)-Flurbiprofen; Flurizan; R-Flurbiprofen; 51543-40-9; (R)-2-Flurbiprofen; MPC-7869; (2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid; (R)-2-Flubiprofen; (2r)-2-(3-Fluoro-4-Phenyl-Phenyl)propanoic Acid; UNII-501W00OOWA; (-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid; CHEMBL190083; CHEBI:38666; (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid; E-7869; (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (R)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid; Flurwood; (2R)-2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid; Urbifen, Ansaid, Flurwood, Froben, Flurbiprofen; Furbiprofen; TruNoc; NSC685699; NCGC00016654-01; (-)-Flurbiprofen; FLP; CAS-5104-49-4; S1679_Selleck; Tocris-1769;|
|Solubility||Soluble to 49 mM at 25ºC in DMSO, to 49 mM at 25ºC in ethanol, to <1 mM at 25ºC in water, to ~25 mM in DMF, and to ~0.9 mM in PBS (pH 7.2).|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -31℃ for long term (months to years).|
|Boiling Point||162.4℃ at 760 mmHg|
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