1.[Interleukin-2 for the treatment of cows with malignant catarrhal fever].
Braun U, Hässig M, Previtali M, Franchini M, Vögtlin A, Storset AK, Ackermann M. Schweiz Arch Tierheilkd. 2015 Jan;157(1):31-8.
The goal of this study was to investigate whether administration of interleukin-2 (IL-2) would improve the outcome of cows with malignant catarrhal fever (MCF). The study population consisted of ten healthy control cows and 22 cows with MCF. Nineteen cows with MCF and all of the controls were treated with either 2'500 U IL-2 or 25'000 U IL-2, administered intravenously. Three cows with MCF were not treated with IL-2 (MCF controls). All of the cows with MCF received danofloxacin, flunixin meglumine and intravenous fluid therapy. Blood samples for haematological and biochemical evaluation were collected once daily for six days in all cows. Of the 19 cows treated with IL-2, 13 were eutha nized because of deterioration. All cows with MCF that did not receive IL-2 died. The clinical condition of six cows treated with 2'500 U IL-2 gradually improved. Sur viving cows had significantly higher total leukocyte counts than cows that died or were euthanized.
2.Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine.
Howard JT1, O'Nan AT1, Maltecca C1, Baynes RE2, Ashwell MS1. PLoS One. 2015 Sep 14;10(9):e0137830. doi: 10.1371/journal.pone.0137830. eCollection 2015.
Characterizing the variability in transcript levels across breeds and sex in swine for genes that play a role in drug metabolism may shed light on breed and sex differences in drug metabolism. The objective of the study is to determine if there is heterogeneity between swine breeds and sex in transcript levels for genes previously shown to play a role in drug metabolism for animals administered flunixin meglumine or fenbendazole. Crossbred nursery female and castrated male pigs (n = 169) spread across 5 groups were utilized. Sires (n = 15) of the pigs were purebred Duroc, Landrace, Yorkshire or Hampshire boars mated to a common sow population. Animals were randomly placed into the following treatments: no drug (control), flunixin meglumine, or fenbendazole. One hour after the second dosing, animals were sacrificed and liver samples collected. Quantitative Real-Time PCR was used to measure liver gene expression of the following genes: SULT1A1, ABCB1, CYP1A2, CYP2E1, CYP3A22 and CYP3A29.
3.Clinical management of dietary induced urolithiasis associated with balanoposthitis in a Boer goat.
Abba Y1, Abdullah FF2, Daud NH3, Shaari RB3, Tijjani A1, Sadiq MA4, Mohammed K4, Adamu L4, Mohd AM1. Open Vet J. 2015;5(1):30-3. Epub 2015 Apr 10.
A Boer-Kajang cross male goat was presented to the Veterinary Hospital, University Malaysia Kelantan with a history of dysuria, hematuria and restlessness. The goat was intensively managed (confined to the pen) and fed with only palm kernel cake for the last three months. Physical examination revealed that the goat was dull, depressed, having an inflamed penis and prepuce with blood stained urine dripping from the penis. The differential diagnoses were obstructive urolithiasis, urinary tract infection and balanoposthitis. Based on the history, clinical signs, physical examination, urinalysis, ultrasonagraphy and feed analysis, the goat was diagnosed with obstructive urolithiasis and balanoposthitis. Treatment was instituted by amputation of the urethral process and retrograde urohydropulsion to relieve the blockade. Sulfadiazine-trimethoprim (Norodine(®)24) 15mg/kg, I.M; flunixin meglumine 2.2mg/kg, I.M; vitamin B complex 1ml/10kg, I.M and ammonium chloride 300mg/kg orally were administered.
4.Clinical features and management of equine postoperative ileus (POI): Survey of Diplomates of the American Colleges of Veterinary Internal Medicine (ACVIM), Veterinary Surgeons (ACVS) and Veterinary Emergency and Critical Care (ACVECC).
Lefebvre D1, Hudson NP1, Elce YA2, Blikslager A3, Divers TJ4, Handel IG1, Tremaine WH5, Pirie RS1. Equine Vet J. 2015 Oct 26. doi: 10.1111/evj.12520. [Epub ahead of print]
REASONS FOR PERFORMING THE STUDY: A recent survey of European Colleges (ECEIM and ECVS) revealed the different strategies implemented by, and some of the challenges facing, European clinicians presented with cases of postoperative ileus (POI). It was concluded that further comparative analysis of opinions, canvassed from additional colleges of equine veterinary specialism worldwide, would provide valuable additional insight into current POI knowledge on a more global scale.