Flunisolide Hemihydrate - CAS 3385-03-3
Catalog number:
3385-03-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H31FO6
Molecular Weight:
434.5
COA:
Inquire
Targets:
Glucocorticoid Receptor
Description:
Flunisolide, a kind of corticosteroid compound, often being used against allergic rhinitis by activating glucocorticoid receptors. It was also found that it mignt have some extent of anti-inflammatory action.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
White solid
Synonyms:
flunisolide;Nasalide;Rhinalar;Syntaris;Aerobid;Nasarel
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Flunisolide is a kind of corticosteroid compound and could often be used against allergic rhinitis by activating glucocorticoid receptors.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
581.8ºC at 760mmHg
Density:
1.33g/cm3
InChIKey:
CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C
InChI:
InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
Canonical SMILES:
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O
1.Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids.
Kew KM1, Beggs S, Ahmad S. Cochrane Database Syst Rev. 2015 May 21;5:CD011316. doi: 10.1002/14651858.CD011316.pub2.
BACKGROUND: Asthma is the most common chronic medical condition among children and is one of the most common causes of hospitalisation and medical visits. Poorly controlled asthma often leads to preventable exacerbations that require additional medications, hospital stays, or treatment in the emergency department.Long-acting beta2-agonists (LABA) are the preferred add-on treatment for children with asthma whose symptoms are not well controlled on inhaled corticosteroids (ICS). The US Food and Drug Administration has issued a 'black box' warning for LABA in asthma, and now recommends that they be used "for the shortest duration of time required to achieve control of asthma symptoms and discontinued, if possible, once asthma control is achieved".
2.Stability and aerodynamic behaviour of glucocorticoid particles prepared by a supercritical fluids process.
Velaga SP1, Bergh S, Carlfors J. Eur J Pharm Sci. 2004 Mar;21(4):501-9.
Particle processing techniques using supercritical fluids (SF) are potential alternative technologies to design particles for inhalation. Powders of budesonide and flunisolide were prepared using solution enhanced dispersion by supercritical fluids (SEDS) process. The aim was to determine thermodynamic stability of different polymorphs of flunisolide including new forms from SEDS technology and to characterise micronised and SEDS produced powders of budesonide and flunisolide for their suitability as inhalation powders. Acetone and methanol solutions of budesonide and flunisolide, with a concentration of 2.5 mg/ml, were used for the particle preparation. The pressure was 100 bar and temperatures were 60 degrees C or 80 degrees C. The flow rates of CO(2) and drug solution were 9 ml/min and 0.3 ml/min, respectively. Chemical purity of different polymorphs of flunisolide was estimated using high performance liquid chromatography (HPLC) and thermal behaviour was determined using differential scanning calorimetry (DSC).
3.Flunisolide for the treatment of asthma.
Melani AS1. Expert Rev Clin Pharmacol. 2014 May;7(3):251-8. doi: 10.1586/17512433.2014.908117. Epub 2014 Apr 9.
Inhaled corticosteroids (ICSs) are recommended for treatment of persistent asthma. Several ICSs are available and delivered by a variety of devices. After the banning of chlorofluorocarbon (CFC), a formulation of hydrofluoroalkane (HFA)-flunisolide marketed with an in-built spacer has been developed, complying with the request of efficacy and safety for children and adults. It delivers an aerosol with mass median aerodynamic diameter smaller than that of the CFC-formulation (1.2 vs 3.8 m). The extrafine aerosol and the add-on spacer are peculiarities of HFA-flunisolide with respect to the traditional ICSs, assuring larger lung deposition, lower oro-pharyngeal dose and targeting small airways. HFA-flunisolide with the spacer is effective at one-third the dose of CFC-flunisolide delivered without spacer. HFA-flunisolide may be considered an effective alternative to currently available ICSs for asthma management of adult and pediatric patients 6 years of age and older.
4.Inhaled corticosteroids in children with persistent asthma: effects on growth.
Zhang L1, Prietsch SO, Ducharme FM. Cochrane Database Syst Rev. 2014 Jul 17;7:CD009471. doi: 10.1002/14651858.CD009471.pub2.
BACKGROUND: Treatment guidelines for asthma recommend inhaled corticosteroids (ICS) as first-line therapy for children with persistent asthma. Although ICS treatment is generally considered safe in children, the potential systemic adverse effects related to regular use of these drugs have been and continue to be a matter of concern, especially the effects on linear growth.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Glucocorticoid Receptor Products


PF-04171327
(CAS: 1044535-58-1)

PF-04171327 is a dissociated agonist of the glucocorticoid receptor (DAGR), which is a selective high-affinity partial agonist of the GR. It has potent anti-inf...

CAS 50-04-4 Cortisone acetate

Cortisone acetate
(CAS: 50-04-4)

Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.

CAS 1177-87-3 Dexamethasone Acetate

Dexamethasone Acetate
(CAS: 1177-87-3)

The acetate-protect form of Dexamethasone which is a glucocorticoid and could be used as a anti-inflammatory agent.

CAS 50-23-7 Hydrocortisone

Hydrocortisone
(CAS: 50-23-7)

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

CAS 356-12-7 Fluocinonide

Fluocinonide
(CAS: 356-12-7)

Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

CAS 50-24-8 Prednisolone

Prednisolone
(CAS: 50-24-8)

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

CAS 638-94-8 Desonide

Desonide
(CAS: 638-94-8)

Desonide is the generic name of a low potency topical corticosteroid that has been available since the 1970s. It is primarily used to treat atopic dermatitis (e...

CHF-6162

CHF-6162 is an agonist of glucocorticoid receptor (GR) (IC50 = 0.24nM), which shows greater potency than fluticasone and budesonide in a radioligand binding ass...

AL 082D06
(CAS: 256925-03-8)

AL 082D06, also called as D-06, is a selective nonsteroidal antagonist of glucocorticoid receptor (GR) (Ki= 210 nM) without significant activity on AR, PR, MR a...

CAS 73771-04-7 Prednicarbate

Prednicarbate
(CAS: 73771-04-7)

Prednicarbate is a glucocorticoid receptor agonist. It is a synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-infla...

CAS 50-02-2 Dexamethasone

Dexamethasone
(CAS: 50-02-2)

Dexamethasone is a glucocorticoid with anti-inflammatory activity that reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differen...

CAS 124-94-7 Triamcinolone

Triamcinolone
(CAS: 124-94-7)

Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topic...

CAS 22427-39-0 Ginsenoside Rg1

Ginsenoside Rg1
(CAS: 22427-39-0)

Ginsenoside Rg1 is extrected from the roots of Panax ginseng C. A. Mey. It has estrogen-like activity and should be classified as a novel class of potent phytoe...

CAS 125-02-0 Prednisolone Sodium Phosphate

Prednisolone Sodium Phosphate
(CAS: 125-02-0)

The disodium phosphate salt form of Prednisolone which has anti-inflammatory and immunsuppressive effect for behaving as a glucocorticoid.

CAS 84371-65-3 Mifepristone

Mifepristone
(CAS: 84371-65-3)

Mifepristone is a progesterone receptor antagonist(IC50= 0.2 nM) and a glucocorticoid receptor antagonist(IC50= 2.6 nM). It is used as an abortifacient in the f...

Betamethasone hydrochloride
(CAS: 956901-32-9)

Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause...

CAS 80474-14-2 Fluticasone propionate

Fluticasone propionate
(CAS: 80474-14-2)

Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever...

CAS 51022-69-6 Amcinonide

Amcinonide
(CAS: 51022-69-6)

Amcinonide is a corticosteroid (IC50=3.38 nM) used as anti-inflammatory and antipruritic agents.

CAS 67-73-2 Fluocinolone Acetonide

Fluocinolone Acetonide
(CAS: 67-73-2)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It was also found to strongly potentia...

CAS 397864-44-7 Fluticasone furoate

Fluticasone furoate
(CAS: 397864-44-7)

Fluticasone furoate is a synthetic corticosteroid derived from fluticasone as a selective high affinity glucocorticoid agonist, MRP4 inhibitor;

Chemical Structure

CAS 3385-03-3 Flunisolide Hemihydrate

Quick Inquiry

Verification code

Featured Items