Flunarizine - CAS 52468-60-7
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Calcium Channel
Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity and duration of attacks of paralysis and is effective in rapid onset dystonia-parkinsonism. It is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children. It was discovered at Janssen Pharmaceutica in 1968. It has been listed.
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Solid powder
Sibelium;Flunarizinum;Flunarizina;(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine;1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine;Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-
Soluble in DMSO, not in water
-20°C Freezer
Flunarizine is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy.
Quality Standard:
In-house standard
Kilograms to Tons
Boiling Point:
511.3±50.0 °C | Condition: Press: 760 Torr
1.170±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
Flunarizine was discovered at Janssen Pharmaceutica in 1968. It has been listed.
1.[Neuropsychological deficits in alternating hemiplegia of childhood: a case study].
Muriel V1, Garcia-Molina A, Aparicio-Lopez C, Ensenat A, Roig-Rovira T. Rev Neurol. 2015 Jul 1;61(1):25-8.
in English, SpanishTITLE: Deficits neuropsicologicos en la hemiplejia alternante infantil: estudio de un caso.
Prashanth KN, Swamy N, Basavaiah K. Acta Pol Pharm. 2016 Jan-Feb;73(1):35-45.
Three indirect methods for the assay of flunarizine dihydrochloride (FNH) in bulk drug and commercial formulation based on titrimetric and spectrophotometric techniques using bromate-bromide mixture are described. In titrimetry, a measured excess of bromate-bromide mixture is added to an acidified solution of FNH and the unreacted bromine is determined iodometrically (method A). Spectrophotometry involves the addition of a known excess of bromate-bromide mixture to FNH in acid medium followed by estimation of unreacted bromine by its reaction with excess iodide and the liberated iodine (I₃⁻) is either measured at 370 nm (method B) or liberated iodine reacted with starch followed by the measurement of the blue colored starch-iodide complex at 575 run (method C). Titrimetric method is applicable over the range 4.5-30.0 mg FNH (method A), and the reaction stoichiometry is found to be 1:2 (FNH:KBrO₃). The spectrophotometric methods are applicable over the concentration ranges 0.
3.Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties.
Pudukulatham Z1, Zhang FX2, Gadotti VM2, M'Dahoma S2, Swami P1, Tamboli Y1, Zamponi GW3. Mol Pain. 2016 Apr 6;12. pii: 1744806916641678. doi: 10.1177/1744806916641678. Print 2016.
BACKGROUND: T-type calcium channels are important contributors to signaling in the primary afferent pain pathway and are thus important targets for the development of analgesics. It has been previously reported that certain piperazine-based compounds such as flunarizine are able to inhibit T-type calcium channels. Thus, we hypothesized that novel piperazine compounds could potentially act as analgesics.
4.A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache.
Jackson JL1, Cogbill E2, Santana-Davila R3, Eldredge C4, Collier W5, Gradall A6, Sehgal N7, Kuester J1. PLoS One. 2015 Jul 14;10(7):e0130733. doi: 10.1371/journal.pone.0130733. eCollection 2015.
OBJECTIVE: To compare the effectiveness and side effects of migraine prophylactic medications.
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CAS 52468-60-7 Flunarizine

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