Flunarizine - CAS 52468-60-7
Catalog number: 52468-60-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Calcium Channel
Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity and duration of attacks of paralysis and is effective in rapid onset dystonia-parkinsonism. It is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children. It was discovered at Janssen Pharmaceutica in 1968. It has been listed.
Publictions citing BOC Sciences Products
  • >> More
Solid powder
Sibelium;Flunarizinum;Flunarizina;(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine;1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine;Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-
Soluble in DMSO, not in water
-20°C Freezer
Flunarizine is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy.
Quality Standard:
In-house standard
Kilograms to Tons
Boiling Point:
511.3±50.0 °C | Condition: Press: 760 Torr
1.170±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
Flunarizine was discovered at Janssen Pharmaceutica in 1968. It has been listed.
1.[Neuropsychological deficits in alternating hemiplegia of childhood: a case study].
Muriel V1, Garcia-Molina A, Aparicio-Lopez C, Ensenat A, Roig-Rovira T. Rev Neurol. 2015 Jul 1;61(1):25-8.
in English, SpanishTITLE: Deficits neuropsicologicos en la hemiplejia alternante infantil: estudio de un caso.
Prashanth KN, Swamy N, Basavaiah K. Acta Pol Pharm. 2016 Jan-Feb;73(1):35-45.
Three indirect methods for the assay of flunarizine dihydrochloride (FNH) in bulk drug and commercial formulation based on titrimetric and spectrophotometric techniques using bromate-bromide mixture are described. In titrimetry, a measured excess of bromate-bromide mixture is added to an acidified solution of FNH and the unreacted bromine is determined iodometrically (method A). Spectrophotometry involves the addition of a known excess of bromate-bromide mixture to FNH in acid medium followed by estimation of unreacted bromine by its reaction with excess iodide and the liberated iodine (I₃⁻) is either measured at 370 nm (method B) or liberated iodine reacted with starch followed by the measurement of the blue colored starch-iodide complex at 575 run (method C). Titrimetric method is applicable over the range 4.5-30.0 mg FNH (method A), and the reaction stoichiometry is found to be 1:2 (FNH:KBrO₃). The spectrophotometric methods are applicable over the concentration ranges 0.
3.Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties.
Pudukulatham Z1, Zhang FX2, Gadotti VM2, M'Dahoma S2, Swami P1, Tamboli Y1, Zamponi GW3. Mol Pain. 2016 Apr 6;12. pii: 1744806916641678. doi: 10.1177/1744806916641678. Print 2016.
BACKGROUND: T-type calcium channels are important contributors to signaling in the primary afferent pain pathway and are thus important targets for the development of analgesics. It has been previously reported that certain piperazine-based compounds such as flunarizine are able to inhibit T-type calcium channels. Thus, we hypothesized that novel piperazine compounds could potentially act as analgesics.
4.A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache.
Jackson JL1, Cogbill E2, Santana-Davila R3, Eldredge C4, Collier W5, Gradall A6, Sehgal N7, Kuester J1. PLoS One. 2015 Jul 14;10(7):e0130733. doi: 10.1371/journal.pone.0130733. eCollection 2015.
OBJECTIVE: To compare the effectiveness and side effects of migraine prophylactic medications.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Calcium Channel Products

CAS 136-47-0 Tetracaine Hydrochloride

Tetracaine Hydrochloride
(CAS: 136-47-0)

Tetracaine hydrochlorideis a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

CAS 72509-76-3 Felodipine

(CAS: 72509-76-3)

Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lower blood pressure by reducing peripheral vascular resistance via a highly ...

CAS 111011-76-8 Efonidipine hydrochloride monoethanolate

Efonidipine hydrochloride monoethanolate
(CAS: 111011-76-8)

The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders.

CAS 1841-19-6 Fluspirilene

(CAS: 1841-19-6)

Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM). Fluspirilene is also a...

CAS 116308-56-6 Watanipidine monohydrochloride

Watanipidine monohydrochloride
(CAS: 116308-56-6)

Watanipidine, also called as AE 0047 or Calbren, is a calcium channel antagonist.

CAS 150493-34-8 NS-638

(CAS: 150493-34-8)

NS-638 is a small nonpeptide Ca(2+)-channel blocker.

CAS 116666-63-8 Mibefradil dihydrochloride hydrate

Mibefradil dihydrochloride hydrate
(CAS: 116666-63-8)

The dihydrochloride hydrate salt form of Mibefradil which is a calcium channel blocker with modest selectivity for T-type Ca2+ channels so that it could be used...

CAS 39562-70-4 Nitrendipine

(CAS: 39562-70-4)

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is used in the treatment of primary (essential) hypertension to decrease bloo...


(CAS: 128229-52-7)

Tamolarizin is a calcium antagonist originated by Nippon Chemiphar. Tamolarizin can induce the increase of GABA in the cerebellum and medulla oblongata followin...

(CAS: 1593673-23-4)

Etripamil, a benzoates derivative, has been found to be a calcium channel antagonist that could be used against hypertension and arrhythmic. It is currently und...

CAS 14663-23-1 Dantrolene Sodium

Dantrolene Sodium
(CAS: 14663-23-1)

Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...

CAS 68291-98-5 Zonisamide sodium salt

Zonisamide sodium salt
(CAS: 68291-98-5)

Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and r...

CAS 129198-88-5 Autocamtide 2

Autocamtide 2
(CAS: 129198-88-5)

Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activit...

CAS 298-57-7 Cinnarizine

(CAS: 298-57-7)

Cinnarizine, with antiallergic and anti-vasoconstricting activity, is a calcium channel blocker to treat cerebral apoplexy, post-trauma cerebral symptoms, and c...

CAS 91599-74-5 Benidipine HCl

Benidipine HCl
(CAS: 91599-74-5)

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

(CAS: 1257116-00-9)

RQ-00311651 is a novel T-type Ca channel inhibitor' which plays a role in neuropathic and visceral pain. RQ-00311651 notably inhibited T currents when tested at...

CAS 52468-60-7 Flunarizine

(CAS: 52468-60-7)

Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity...

CAS 79700-61-1 Dopropidil

(CAS: 79700-61-1)

Dopropidil, also called as ORG 30701, is a cardioactive drug to be classified as a calcium antagonist with combined class I and class VI antiarrhythmic properti...

PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

CAS 66085-59-4 Nimodipine

(CAS: 66085-59-4)

Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intrac...

Chemical Structure

CAS 52468-60-7 Flunarizine

Quick Inquiry

Verification code

Featured Items