Flufenamic acid - CAS 530-78-9
Catalog number: 530-78-9
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
Flufenamic Acid; CI-440; CN-27554; INF-1837; CI 440; CN 27554; INF 1837; CI440; CN27554; INF1837
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1.Mesoporous silica based MCM-41 as solid-phase extraction sorbent combined with micro-liquid chromatography-quadrupole-mass spectrometry for the analysis of pharmaceuticals in waters.
Dahane S1, Martínez Galera M2, Marchionni ME3, Socías Viciana MM4, Derdour A5, Gil García MD4. Talanta. 2016 May 15;152:378-91. doi: 10.1016/j.talanta.2016.02.013. Epub 2016 Feb 13.
This paper reports the first application of the silica based mesoporous material MCM-41 as a sorbent in solid phase extraction, to pre-concentrate pharmaceuticals of very different polarity (atenolol, nadolol, pindolol, timolol, bisoprolol, metoprolol, betaxolol, ketoprofen, naproxen, ibuprofen, diclofenac, tolfenamic acid, flufenamic acid and meclofenamic acid) in surface waters. The analytes were extracted from 100mL water samples at pH 2.0 (containing 10(-3)mol/L of sodium chloride) by passing the solution through a cartridge filled with 100mg of MCM-41. Following elution, the pharmaceuticals were determined by micro-liquid chromatography and triple quadrupole-mass spectrometry. Two selected reaction monitoring transitions were monitored per compound, the most intense one being used for quantification and the second one for confirmation. Matrix effect was found in real waters for most analytes and was overcome using the standard addition method, which compared favorably with the matrix matched calibration method.
2.Impact of APCI ionization source in liquid chromatography tandem mass spectrometry based tissue distribution studies.
Khatal L1, Gaur A1, Naphade A1, Kandikere V1, Mookhtiar K1. Biomed Chromatogr. 2016 Apr 15. doi: 10.1002/bmc.3740. [Epub ahead of print]
Measuring test article concentration in tissue samples has been an important part of Pharmacokinetic study which helped to co-relate pharmacokinetic/pharmacodynamic relationships, since 1950s and 1960s. Bioanalysis of tissue samples using LC-MS/MS comes with unique challenges in terms of sample handling and inconsistent analyte response due to non-volatile matrix components. Matrix Effect (ME) is a phenomenon where target analyte response either gets suppressed or enhanced in presence of matrix components. Based on previous reports electrospray ionization (ESI) mode of ionization is believed to be more affected by matrix components than atmospheric pressure chemical ionization (APCI) or atmospheric pressure photo ionization (APPI) mode. To explore the impact of ionization source with respect to bioanalysis of tissue samples five structurally diverse compounds like atenolol, verapamil, diclofenac, propranolol and flufenamic acid were selected, quality control standard were spiked in ten different biological matrices like whole blood, liver, heart, brain, spleen, kidney, skeletal muscle, eye and skin tissue and were quantified against calibration standards prepared in rat plasma.
3.Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus).
Lavrov I1, Fox L2, Shen J2, Han Y3, Cheng J2. PLoS One. 2016 Mar 29;11(3):e0152650. doi: 10.1371/journal.pone.0152650. eCollection 2016.
Although gap junctions are widely expressed in the developing central nervous system, the role of electrical coupling of neurons and glial cells via gap junctions in the spinal cord in adults is largely unknown. We investigated whether gap junctions are expressed in the mature spinal cord of the mudpuppy and tested the effects of applying gap junction blocker on the walking-like activity induced by NMDA or glutamate in an in vitro mudpuppy preparation. We found that glial and neural cells in the mudpuppy spinal cord expressed different types of connexins that include connexin 32 (Cx32), connexin 36 (Cx36), connexin 37 (Cx37), and connexin 43 (Cx43). Application of a battery of gap junction blockers from three different structural classes (carbenexolone, flufenamic acid, and long chain alcohols) substantially and consistently altered the locomotor-like activity in a dose-dependent manner. In contrast, these blockers did not significantly change the amplitude of the dorsal root reflex, indicating that gap junction blockers did not inhibit neuronal excitability nonselectively in the spinal cord.
4.mGluR-mediated calcium signalling in the thalamic reticular nucleus.
Neyer C1, Herr D1, Kohmann D1, Budde T1, Pape HC1, Coulon P2. Cell Calcium. 2016 Mar 28. pii: S0143-4160(16)30028-8. doi: 10.1016/j.ceca.2016.03.009. [Epub ahead of print]
The thalamic reticular nucleus (TRN) plays a major role in modulating the transfer of information from the thalamus to the cortex. GABAergic inhibition via the TRN is differentially regulated by metabotropic glutamate receptors (mGluRs) and the effect of mGluRs on the membrane potential, on ion channels, and on the plasticity of electrical coupling of TRN neurons has been studied previously. Although mGluRs are generally known to trigger Ca2+ transients, mGluR-mediated Ca2+-transients in TRN neurons have not yet been investigated. In this study, we show that mGluRs can trigger Ca2+-transients in TRN neurons, that these transients depend on intracellular Ca2+-stores, and are mediated by IP3 receptors. Ca2+ transients caused by the group I mGluR agonist DHPG elicit a current that is sensitive to flufenamic acid and has a reversal potential around -40mV. Our results add mGluR-mediated Ca2+-signalling in the TRN to the state-dependent modulators of the thalamocortical system.
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CAS 530-78-9 Flufenamic acid

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