Fludrocortisone Acetate - CAS 514-36-3
Catalog number:
514-36-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H31FO6
Molecular Weight:
422.50
COA:
Inquire
Targets:
Others
Description:
Fludrocortisone acetate is a synthetic corticosteroid used as a mineralocorticoid.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
White to Off-White Solid
Synonyms:
Scherofluron; Florinef acetate; Alflorone acetate; [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A mineralocorticoid.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
>201 ºC
InChIKey:
SYWHXTATXSMDSB-GSLJADNHSA-N
InChI:
1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
Canonical SMILES:
CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O
1.Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat.
Koutinas CK1, Soubasis NC1, Djajadiningrat-Laanen SC1, Kolia E1, Theodorou K1. J Am Anim Hosp Assoc. 2015 Sep-Oct;51(5):338-41. doi: 10.5326/JAAHA-MS-6201.
A 9 yr old cat was presented with clinical signs and laboratory abnormalities attributed to arterial hypertension (mean systolic arterial pressure, 290 mm Hg). Plasma aldosterone concentration was increased at the time of admission (651 pmol/L), but serum creatinine and potassium concentrations were within the reference range. A second increased aldosterone (879 pmol/L) and normal plasma renin activity (1.85 ng/mL/hr) resulted in an increased aldosterone/renin ratio, which was suggestive of primary hyperaldosteronism (PHA). To further support the diagnosis of PHA, the urinary aldosterone/creatinine ratio was calculated both before and after oral administration of fludrocortisone acetate (0.05 mg/kg q 12 hr for 4 consecutive days). The urinary aldosterone/creatinine ratio was 92.6 × 10(-9) before fludrocortisone administration and 155.8 × 10(-9) 4 days later. Absence of suppression was typical of PHA. The cat had a limited response to antihypertensive medication and died before treatment for PHA could be instituted.
2.Generalized vitiligo in a dog with primary hypoadrenocorticism.
Malerba E1, Morini M1, Fracassi F1. Vet Dermatol. 2015 Oct;26(5):376-8, e86. doi: 10.1111/vde.12228. Epub 2015 Jun 23.
BACKGROUND: Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune-mediated destruction of the adrenal cortex.
3.Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity.
Ishiguro H1, Kawahara T, Zheng Y, Kashiwagi E, Li Y, Miyamoto H. Cancer Chemother Pharmacol. 2014 Aug;74(2):249-55. doi: 10.1007/s00280-014-2496-7. Epub 2014 Jun 1.
PURPOSE: A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but increased cell proliferation via inhibiting apoptosis particularly induced by cisplatin. Therefore, comedication with dexamethasone in bladder cancer patients may lead to unfavorable outcomes such as chemoresistance. We here look for any glucocorticoids with inhibitory effects on tumor cell invasion yet inhibitory or at least no stimulatory effects on cell viability.
4.Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone.
Baumstark ME1, Nussberger J, Boretti FS, Baumstark MW, Riond B, Reusch CE, Sieber-Ruckstuhl NS. J Vet Intern Med. 2014 Sep-Oct;28(5):1471-8. doi: 10.1111/jvim.12426.
BACKGROUND: Measurement of plasma renin activity (PRA) is the gold standard for monitoring mineralocorticoid treatment in humans with primary hypoadrenocorticism (PH).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 465-65-6 Naloxone

Naloxone
(CAS: 465-65-6)

Naloxone is a medication used to block the effects of opioids, especially in overdose useful both in acute opioid overdose and in reducing respiratory or mental...

c-Myc Peptide

c-Myc Peptide, a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, is a useful for displacement of c-Myc-tagged fu...

CAS 479-98-1 Aucubin

Aucubin
(CAS: 479-98-1)

Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor acti...

CAS 1821428-35-6 AZD0156

AZD0156
(CAS: 1821428-35-6)

AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage c...

GSK-7975A
(CAS: 1253186-56-9)

This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activatio...

CAS 58-60-6 Puromycin aminonucleoside

Puromycin aminonucleoside
(CAS: 58-60-6)

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, which is a puromycin analog which does not inhibit protein synthesis or in...

CAS 47931-85-1 Calcitonin salmon

Calcitonin salmon
(CAS: 47931-85-1)

Calcitonin salmon, a calcium regulating hormone, has been shown to be an effective alternative for the treatment of postmenopausal osteoporosis.

CAS 52286-58-5 Ginsenoside Rf

Ginsenoside Rf
(CAS: 52286-58-5)

Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, an anti-arthritic agent, attenuating collagen-induced arthritis in mice.

CAS 9005-49-6 Heparin

Heparin
(CAS: 9005-49-6)

Heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological...

CAS 60482-95-3 Neurotensin(8-13)

Neurotensin(8-13)
(CAS: 60482-95-3)

Neurotensin (8-13), the smallest active fragment of neurotensin, results in a decrease in cell-surface NT1 receptors (NTR1) density.

CAS 6284-40-8 Meglumine

Meglumine
(CAS: 6284-40-8)

Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL.

CAS 169105-89-9 Isofagomine

Isofagomine
(CAS: 169105-89-9)

Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease.

ARV-825
(CAS: 1818885-28-7)

ARV-825, a BRD4 inhibitor, has extensive anti-AML activity and modulates tumor microenvironment and metabolism to overcome stromamediated drug resistance. DC50...

CAS 111-48-8 Thiodiglycol

Thiodiglycol
(CAS: 111-48-8)

Thiodiglycol, the hydrolysis product of sulfur mustard, is useful in textile dyeing and sorts of pen ink manufacturing. It could produce mustard gas reacted wit...

Rabies Virus Glycoprotein

Rabies Virus Glycoprotein, a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein, is only structural protein of the virus that induc...

CAS 3734-33-6 Denatonium benzoate

Denatonium benzoate
(CAS: 3734-33-6)

Denatonium benzoate is a stimulant of the bitter taste receptors used as aversive agents (bitterants) to prevent inappropriate ingestion.

CAS 81025-04-9 Lactitol monohydrate

Lactitol monohydrate
(CAS: 81025-04-9)

Lactitol monohydrate is an analogue of disaccharide lactulose. lt is used as replacement sweeteners and has been used in the treatment of constipation & hepatic...

CAS 886-50-0 Terbutryn

Terbutryn
(CAS: 886-50-0)

Terbutryn is a chemical compound with a triazine ring as a basic structure. It is used as a herbicide. It also acts as an inhibitor of photosynthesis. It is abs...

CAS 38642-49-8 Benzoylpaeoniflorin

Benzoylpaeoniflorin
(CAS: 38642-49-8)

Benzoylpaeoniflorin was found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.

CAS 3458-22-8 IPD Hydrochloride

IPD Hydrochloride
(CAS: 3458-22-8)

IPD is an alkylsulfonate DNA crosslinker.

Chemical Structure

CAS 514-36-3 Fludrocortisone Acetate

Quick Inquiry

Verification code

Featured Items