Fludrocortisone Acetate - CAS 514-36-3
Catalog number: 514-36-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C23H31FO6
Molecular Weight:
422.50
COA:
Inquire
Targets:
Others
Description:
Fludrocortisone acetate is a synthetic corticosteroid used as a mineralocorticoid.
Purity:
≥95%
Appearance:
White to Off-White Solid
Synonyms:
Scherofluron; Florinef acetate; Alflorone acetate; [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A mineralocorticoid.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
>201 ºC
InChIKey:
SYWHXTATXSMDSB-GSLJADNHSA-N
InChI:
1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
Canonical SMILES:
CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O
1.Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat.
Koutinas CK1, Soubasis NC1, Djajadiningrat-Laanen SC1, Kolia E1, Theodorou K1. J Am Anim Hosp Assoc. 2015 Sep-Oct;51(5):338-41. doi: 10.5326/JAAHA-MS-6201.
A 9 yr old cat was presented with clinical signs and laboratory abnormalities attributed to arterial hypertension (mean systolic arterial pressure, 290 mm Hg). Plasma aldosterone concentration was increased at the time of admission (651 pmol/L), but serum creatinine and potassium concentrations were within the reference range. A second increased aldosterone (879 pmol/L) and normal plasma renin activity (1.85 ng/mL/hr) resulted in an increased aldosterone/renin ratio, which was suggestive of primary hyperaldosteronism (PHA). To further support the diagnosis of PHA, the urinary aldosterone/creatinine ratio was calculated both before and after oral administration of fludrocortisone acetate (0.05 mg/kg q 12 hr for 4 consecutive days). The urinary aldosterone/creatinine ratio was 92.6 × 10(-9) before fludrocortisone administration and 155.8 × 10(-9) 4 days later. Absence of suppression was typical of PHA. The cat had a limited response to antihypertensive medication and died before treatment for PHA could be instituted.
2.Generalized vitiligo in a dog with primary hypoadrenocorticism.
Malerba E1, Morini M1, Fracassi F1. Vet Dermatol. 2015 Oct;26(5):376-8, e86. doi: 10.1111/vde.12228. Epub 2015 Jun 23.
BACKGROUND: Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune-mediated destruction of the adrenal cortex.
3.Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity.
Ishiguro H1, Kawahara T, Zheng Y, Kashiwagi E, Li Y, Miyamoto H. Cancer Chemother Pharmacol. 2014 Aug;74(2):249-55. doi: 10.1007/s00280-014-2496-7. Epub 2014 Jun 1.
PURPOSE: A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but increased cell proliferation via inhibiting apoptosis particularly induced by cisplatin. Therefore, comedication with dexamethasone in bladder cancer patients may lead to unfavorable outcomes such as chemoresistance. We here look for any glucocorticoids with inhibitory effects on tumor cell invasion yet inhibitory or at least no stimulatory effects on cell viability.
4.Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone.
Baumstark ME1, Nussberger J, Boretti FS, Baumstark MW, Riond B, Reusch CE, Sieber-Ruckstuhl NS. J Vet Intern Med. 2014 Sep-Oct;28(5):1471-8. doi: 10.1111/jvim.12426.
BACKGROUND: Measurement of plasma renin activity (PRA) is the gold standard for monitoring mineralocorticoid treatment in humans with primary hypoadrenocorticism (PH).
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CAS 514-36-3 Fludrocortisone Acetate

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