Fluconazole hydrate - CAS 155347-36-7
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Fluconazole (hydrate) is the hydrate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h.
Publictions citing BOC Sciences Products
  • >> More
UK 49858 hydrate; UK49858 hydrate; UK-49858 hydrate
1.Solid-state characterization of fluconazole.
Alkhamis KA1, Obaidat AA, Nuseirat AF. Pharm Dev Technol. 2002 Nov;7(4):491-503.
Two polymorphs and three solvates of fluconazole were isolated and characterized by x-ray powder diffractometry, IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetry, and their dissolution rates. The different forms were prepared by crystallization of the original powder in different solvents at different cooling rates. X-ray diffraction patterns of the five solid modifications exhibited substantial differences in both the intensity and position of the peaks. FTIR spectra of the five different solid-state modifications also exhibited differences in the peaks' positions and intensities. DSC thermogram of anhydrate form I showed a single melting point at 139.2 degrees C. Anhydrate form II showed two endothermic peaks at 136.5 and 139.2 degrees C and one exothermic peak in between. The DSC thermogram of acetone 1/4 solvate exhibited two endothermic peaks at 75.5 and 139.2 degrees C. Benzene 1/7 solvate exhibited two endothermic peaks at 131.
2.[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].
Imokawa S1, Mori K, Harada M, Sagisaka S, Sano T, Uchiyama H, Yasuda K, Ukita T, Fujisawa T, Suda T, Chida K. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.
A 22-year-old man was admitted to our hospital with fever, cough and dyspnea. His chest radiograph showed diffuse ground-glass attenuation in both lung fields. Arterial blood gas analysis showed hypoxemia (PaO2 28.7 Torr breathing room air) and he required mechanical ventilation within 6 hours after admission. Gomori methenamine silver (GMS) stain of the bronchoalveolar lavage (BAL) fluid smear showed round and indented organisms, and polymerase chain reaction revealed pneumocystis jirovecii in the BAL fluid. The HIV antibody was positive and peripheral blood CD4-positive lymphocytes decreased to 4.0%. Pneumocystis pneumonia complicated with acquired immunodeficiency syndrome (AIDS) was diagnosed. There was no four-fold rise in screen viral titers. We treated him with antibiotics, trimethoprim-sulfamethoxazole, ganciclovir, fos-fluconazole, steroid pulse therapy and sivelestat sodium hydrate. Respiratory failure was relieved within 5 days following treatment.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products

CAS 78628-80-5 Terbinafine HCl

Terbinafine HCl
(CAS: 78628-80-5)

Terbinafine HCl is a hydrochloride salt of terbinafine that is a synthetic allylamine antifungal and a squalene epoxidase inhibitor with an IC50 of 30 nM for Ca...

CAS 174671-46-6 AN-2690

(CAS: 174671-46-6)

Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct wit...

CAS 73151-29-8 Fenticonazole Nitrate

Fenticonazole Nitrate
(CAS: 73151-29-8)

Fenticonazole Nitrate is an azole antifungal agent.

CAS 137234-62-9 Voriconazole

(CAS: 137234-62-9)

Voriconazole inhibits 95% of isolates at ≤1 μg/ml against 448 recent clinical mold isolates

CAS 114-26-1 Sendran

(CAS: 114-26-1)

Propoxur, a carbamate derivative, could be widely used as an insecticide against sorts of agricultural pests.

CAS 64872-77-1 Butoconazole nitrate

Butoconazole nitrate
(CAS: 64872-77-1)

Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.

CAS 208538-73-2 Micafungin Sodium

Micafungin Sodium
(CAS: 208538-73-2)

Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.

CAS 7716-60-1 Etisazole

(CAS: 7716-60-1)

Etoxazole is a narrow spectrum systemic acaricide used to combat spider mites.


CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A virus M1 protein, and was first described in the yeast Saccharomyces cerevisiae and has subsequently...

CAS 86386-73-4 Fluconazole

(CAS: 86386-73-4)

Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol, used in the treatment and prevention of s...

CAS 179463-17-3 Caspofungin Acetate

Caspofungin Acetate
(CAS: 179463-17-3)

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of f...

CAS 68890-66-4 Piroctone olamine

Piroctone olamine
(CAS: 68890-66-4)

Piroctone olamine, a pyridine derivate, is an anti-dandruff agent with fungicidal effect used in shampoo formulations.

CAS 198022-65-0 Icofungipen

(CAS: 198022-65-0)

Icofungipen, a cyclic β-amino acid, is the representative of a novel class of antifungals, active against Candida. Its in vivo efficacy indicates its potential ...

CAS 1265166-14-0 Antifungal agent 1

Antifungal agent 1
(CAS: 1265166-14-0)

A potent antifungalagent

CAS 1400-61-9 Nystatin

(CAS: 1400-61-9)

Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.

CAS 171228-49-2 Posaconazole

(CAS: 171228-49-2)

Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

CAS 136212-91-4 Dermaseptin

(CAS: 136212-91-4)

Dermaseptin is a 34-residue antimicrobial peptide.

CAS 22916-47-8 Miconazole

(CAS: 22916-47-8)

Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal in...

CAS 159532-41-9 Fluconazole mesylate

Fluconazole mesylate
(CAS: 159532-41-9)

Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses....

CAS 135575-42-7 Pneumocandin B0

Pneumocandin B0
(CAS: 135575-42-7)

Pneumocandin B0, also called as L 688786, is an inhibitor of ß-(1,3)-D-glucan (a component of fungal cell walls) synthesis with an antifungal effect (IC50s = 70...

Chemical Structure

CAS 155347-36-7 Fluconazole hydrate

Quick Inquiry

Verification code

Featured Items