Fluconazole hydrate - CAS 155347-36-7
Catalog number: 155347-36-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C13H14F2N6O2
Molecular Weight:
324.29
COA:
Inquire
Targets:
Antifungal
Description:
Fluconazole (hydrate) is the hydrate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h.
Purity:
>98%
Synonyms:
UK 49858 hydrate; UK49858 hydrate; UK-49858 hydrate
MSDS:
Inquire
InChIKey:
QSZFKRINVAUJGQ-UHFFFAOYSA-N
InChI:
InChI=1S/C13H12F2N6O.H2O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21;/h1-3,6-9,22H,4-5H2;1H2
Canonical SMILES:
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O.O
1.Solid-state characterization of fluconazole.
Alkhamis KA1, Obaidat AA, Nuseirat AF. Pharm Dev Technol. 2002 Nov;7(4):491-503.
Two polymorphs and three solvates of fluconazole were isolated and characterized by x-ray powder diffractometry, IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetry, and their dissolution rates. The different forms were prepared by crystallization of the original powder in different solvents at different cooling rates. X-ray diffraction patterns of the five solid modifications exhibited substantial differences in both the intensity and position of the peaks. FTIR spectra of the five different solid-state modifications also exhibited differences in the peaks' positions and intensities. DSC thermogram of anhydrate form I showed a single melting point at 139.2 degrees C. Anhydrate form II showed two endothermic peaks at 136.5 and 139.2 degrees C and one exothermic peak in between. The DSC thermogram of acetone 1/4 solvate exhibited two endothermic peaks at 75.5 and 139.2 degrees C. Benzene 1/7 solvate exhibited two endothermic peaks at 131.
2.[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].
Imokawa S1, Mori K, Harada M, Sagisaka S, Sano T, Uchiyama H, Yasuda K, Ukita T, Fujisawa T, Suda T, Chida K. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.
A 22-year-old man was admitted to our hospital with fever, cough and dyspnea. His chest radiograph showed diffuse ground-glass attenuation in both lung fields. Arterial blood gas analysis showed hypoxemia (PaO2 28.7 Torr breathing room air) and he required mechanical ventilation within 6 hours after admission. Gomori methenamine silver (GMS) stain of the bronchoalveolar lavage (BAL) fluid smear showed round and indented organisms, and polymerase chain reaction revealed pneumocystis jirovecii in the BAL fluid. The HIV antibody was positive and peripheral blood CD4-positive lymphocytes decreased to 4.0%. Pneumocystis pneumonia complicated with acquired immunodeficiency syndrome (AIDS) was diagnosed. There was no four-fold rise in screen viral titers. We treated him with antibiotics, trimethoprim-sulfamethoxazole, ganciclovir, fos-fluconazole, steroid pulse therapy and sivelestat sodium hydrate. Respiratory failure was relieved within 5 days following treatment.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products


CAS 38083-17-9 Climbazole

Climbazole
(CAS: 38083-17-9)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high...

CAS 1265166-14-0 Antifungal agent 1

Antifungal agent 1
(CAS: 1265166-14-0)

A potent antifungalagent

CAS 141-94-6 Hexetidine

Hexetidine
(CAS: 141-94-6)

Hexetidine, mixture of stereoisomers, is an antibacterial and antifungal agent that destroy fungi by suppressing their ability to grow or reproduce.

CAS 83657-24-3 Diniconazole

Diniconazole
(CAS: 83657-24-3)

Diniconazol is a chemical compound belonging to chlorine group of conazole. It is used as a fungicide. It inhibited lanosterol 14 alpha-demethylation catalyzed ...

CAS 53370-90-4 Exalamide

Exalamide
(CAS: 53370-90-4)

Exalamide is a derivative of salicylamide used as an antifungal.

CAS 159532-41-9 Fluconazole mesylate

Fluconazole mesylate
(CAS: 159532-41-9)

Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses....

CAS 137234-62-9 Voriconazole

Voriconazole
(CAS: 137234-62-9)

Voriconazole inhibits 95% of isolates at ≤1 μg/ml against 448 recent clinical mold isolates

CAS 135575-42-7 Pneumocandin B0

Pneumocandin B0
(CAS: 135575-42-7)

Pneumocandin B0, also called as L 688786, is an inhibitor of ß-(1,3)-D-glucan (a component of fungal cell walls) synthesis with an antifungal effect (IC50s = 70...

Chemical Structure

CAS 155347-36-7 Fluconazole hydrate

Quick Inquiry

Verification code

Featured Items