Flibanserin - CAS 167933-07-5
Catalog number: 167933-07-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H21F3N4O
Molecular Weight:
390.40
COA:
Inquire
Targets:
5-HT Receptor
Description:
Flibanserin, a benzimidazole derivative, has been found to be a Serotonin 1A/2A receptor agonist that was once studied as antidepressant as well as anxiolytic agent and could be used against female sexual dysfunction.
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Purity:
98%
Appearance:
Powder
Synonyms:
Flibanserin;Bimt 17;3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
Density:
1.292 g/cm3
InChIKey:
PPRRDFIXUUSXRA-UHFFFAOYSA-N
InChI:
InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
Canonical SMILES:
C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
1.Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis.
Jaspers L1, Feys F2, Bramer WM3, Franco OH1, Leusink P4, Laan ET5. JAMA Intern Med. 2016 Apr 1;176(4):453-62. doi: 10.1001/jamainternmed.2015.8565.
IMPORTANCE: In August 2015, the US Food and Drug Administration (FDA) approved flibanserin as a treatment for hypoactive sexual desire disorder (HSDD) in premenopausal women, despite concern about suboptimal risk-benefit trade-offs.
2.[Female sexual dysfunction: Drug treatment options].
Alcántara Montero A1, Sánchez Carnerero CI2. Semergen. 2016 Mar 31. pii: S1138-3593(16)00088-5. doi: 10.1016/j.semerg.2016.02.008. [Epub ahead of print]
Many women will likely experience a sexual problem in their lifetime. Female sexual dysfunction is a broad term used to describe 3 categories of disorders of a multifactorial nature. Effective, but limited pharmacotherapeutic options exist to address female sexual dysfunction. The FDA recently approved the first agent for treatment of hypoactive sexual desire disorder in pre-menopausal women. Off-label use of hormonal therapies, particularly oestrogen and testosterone, are the most widely employed for female sexual dysfunction, particularly in post-menopausal women. Other drugs currently under investigation include phosphodiesterase inhibitors and agents that modulate dopamine or melanocortin receptors.
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CAS 167933-07-5 Flibanserin

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