Flibanserin - CAS 167933-07-5
Catalog number: 167933-07-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H21F3N4O
Molecular Weight:
390.40
COA:
Inquire
Targets:
5-HT Receptor
Description:
Flibanserin, a benzimidazole derivative, has been found to be a Serotonin 1A/2A receptor agonist that was once studied as antidepressant as well as anxiolytic agent and could be used against female sexual dysfunction.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Flibanserin;Bimt 17;3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
Density:
1.292 g/cm3
InChIKey:
PPRRDFIXUUSXRA-UHFFFAOYSA-N
InChI:
InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
Canonical SMILES:
C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
1.Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis.
Jaspers L1, Feys F2, Bramer WM3, Franco OH1, Leusink P4, Laan ET5. JAMA Intern Med. 2016 Apr 1;176(4):453-62. doi: 10.1001/jamainternmed.2015.8565.
IMPORTANCE: In August 2015, the US Food and Drug Administration (FDA) approved flibanserin as a treatment for hypoactive sexual desire disorder (HSDD) in premenopausal women, despite concern about suboptimal risk-benefit trade-offs.
2.[Female sexual dysfunction: Drug treatment options].
Alcántara Montero A1, Sánchez Carnerero CI2. Semergen. 2016 Mar 31. pii: S1138-3593(16)00088-5. doi: 10.1016/j.semerg.2016.02.008. [Epub ahead of print]
Many women will likely experience a sexual problem in their lifetime. Female sexual dysfunction is a broad term used to describe 3 categories of disorders of a multifactorial nature. Effective, but limited pharmacotherapeutic options exist to address female sexual dysfunction. The FDA recently approved the first agent for treatment of hypoactive sexual desire disorder in pre-menopausal women. Off-label use of hormonal therapies, particularly oestrogen and testosterone, are the most widely employed for female sexual dysfunction, particularly in post-menopausal women. Other drugs currently under investigation include phosphodiesterase inhibitors and agents that modulate dopamine or melanocortin receptors.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 113777-40-5 MDL 72832 hydrochloride

MDL 72832 hydrochloride
(CAS: 113777-40-5)

MDL 72832 hydrochloride is a potent ligand at 5-HT1A receptors, with mixed agonist and antagonist properties.

CAS 186544-26-3 LY 344864

LY 344864
(CAS: 186544-26-3)

LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...

CAS 87760-53-0 Tandospirone

Tandospirone
(CAS: 87760-53-0)

Tandospironeis a potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM. It significantly reduces haloperidol-induced bradykinesia in a dose depe...

CAS 193611-72-2 BRL-15572

BRL-15572
(CAS: 193611-72-2)

BRL-15572 displays high affinity and selectivity for h5-HT1D receptors. BRL-15572 has 60-fold higher affinity for h5-HT1D than 5-HT1B receptors.

CAS 5560-59-8 Alverine Citrate

Alverine Citrate
(CAS: 5560-59-8)

Alverine Citrate is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

SB 242084 hydrochloride
(CAS: 1260505-34-7)

SB 242084 hydrochloride is a selective and brain penetrant 5-HT2C receptor antagonist with over 100-fold selectivity versus a range of other 5-HT, dopamine and ...

CAS 1977-08-8 Isoclozapine

Isoclozapine
(CAS: 1977-08-8)

Isoclozapine is a 2-Cl analogue of clozapine as a typical antipsychotic.

CAS 171205-17-7 N-Methylquipazine dimaleate

N-Methylquipazine dimaleate
(CAS: 171205-17-7)

N-Methylquipazine dimaleate, a tertiary amine analog of quipazine, is a 5-HT3 agonist, which has almost the same affinity for 5-HT3 sites as quipazine but unlik...

CAS 138982-67-9 Ziprasidone hydrochloride monohydrate

Ziprasidone hydrochloride monohydrate
(CAS: 138982-67-9)

The hydrochloride monohydrate salt form of Ziprasidone, a benzothiazol derivative, has been found to be a 5HT2A and D2 receptor antagonist that could be used ag...

CAS 109889-09-0 Granisetron

Granisetron
(CAS: 109889-09-0)

Granisetron is an antagonist of serptpmom 5-HT3 receptor and could be used to relieve the nausea and vomiting symptom after receving chemotherapy by decreasing ...

CAS 112457-95-1 Tandospirone citrate

Tandospirone citrate
(CAS: 112457-95-1)

The citrate salt form of tandospirone, a partial 5HT1A receptors agonist, could be effective as an antianxiety and antidepressant agent.

CAS 1216468-02-8 SB 258585 hydrochloride

SB 258585 hydrochloride
(CAS: 1216468-02-8)

SB 258585 hydrochloride is a potent and selective 5-HT6 receptor antagonist (pKi = 8.6) with > 160-fold selectivity over other 5-HT receptor subtypes, dopamine ...

CAS 163521-12-8 Vilazodone

Vilazodone
(CAS: 163521-12-8)

Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evalu...

CAS 148672-15-5 GMC 2-29

GMC 2-29
(CAS: 148672-15-5)

GMC 2-29 is a potent and selective 5-HT1B/1D antagonist.

CAS 132539-06-1 Olanzapine

Olanzapine
(CAS: 132539-06-1)

Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscar...

CAS 193611-67-5 SB 216641 hydrochloride

SB 216641 hydrochloride
(CAS: 193611-67-5)

SB 216641 hydrochloride is a selective h5-HT1B antagonist with ~ 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.

Revexepride
(CAS: 219984-49-3)

Revexepride, also referred as SSP-002358, is a very selective and potent 5-HT4 receptor agonist and a novel prokinetic that stimulates gastrointestinal motility...

Sarizotan HCl
(CAS: 195068-07-6)

Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa...

CAS 190508-50-0 AT 1015

AT 1015
(CAS: 190508-50-0)

AT 1015 has been found to be a 5-HT2A receptor antagonist and exhibit antithrombotic activities.

CAS 157798-13-5 5-Nonyloxytryptamine oxalate

5-Nonyloxytryptamine oxalate
(CAS: 157798-13-5)

5-Nonyloxytryptamine oxalate is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 c...

Chemical Structure

CAS 167933-07-5 Flibanserin

Quick Inquiry

Verification code

Featured Items