FLI-06 - CAS 313967-18-9
Catalog number: 313967-18-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H30N2O5
Molecular Weight:
438.22
COA:
Inquire
Targets:
Amyloid-β | Notch
Description:
FLI-06 , a Notch inhibitor that disrupts Notch trafficking and processing, disrupts the Golgi by mechanisms different from BFA or GCA. It Reduces amyloid β secretion.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
Inhibits Notch signaling (EC50 = 2.3 μM); Reduces amyloid β secretion
Appearance:
White solid powder
Synonyms:
cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate; FLI-06; 313967-18-9; cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; STK368879; AC1MIXAW; BAS 00380830; Oprea1_143746; Oprea1_499413; FLI 06; SCHEMBL15536952; AOB2707; SYN5099; 2412AH; AKOS000650664; AKOS021985195; CS-2407; MCULE-5112819342; BC600549; HY-15860; ST50001800; S7399,313967-18-9; 4-(4-Nitrophenyl)-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid cyclohexyl ester; cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,7,8-pentahydroquinoli ne-3-carboxylate; FLI 06|Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -43℃ for long term (months to years).
MSDS:
Inquire
Density:
1.25±0.1 g/cm3
InChIKey:
SWWVFYHSSOWZMF-UHFFFAOYSA-N
InChI:
1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
Canonical SMILES:
CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Amyloid-β Products


CAS 290315-45-6 BMS 299897

BMS 299897
(CAS: 290315-45-6)

BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynth...

AC 186
(CAS: 1421854-16-1)

AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's dise...

CAS 1192750-33-6 PE 154

PE 154
(CAS: 1192750-33-6)

PE 154 is a fluorescent inhibitor of both AChE and BChE with IC50 values of 280 pM and 16 nM. PE 154 targets and labels β-amyloid plaques in histochemical analy...

CAS 937812-80-1 gamma-Secretase modulators

gamma-Secretase modulators
(CAS: 937812-80-1)

gamma-Secretase Modulators, as a potent modulator of γ-secretase, it is derived from oxadiazine. IC50: Aβ42=11 nM, Aβtotal/ Aβ42=1170.

CAS 35825-57-1 Cryptotanshinone

Cryptotanshinone
(CAS: 35825-57-1)

Cryptotanshinone, a natural cell-permeable diterpene quinone isolated from Salvia miltiorrhiza, it inhibits acetylcholinesterase (IC50 = 4.09 μM) and reduces Aβ...

CAS 1584713-87-0 BMS-983970

BMS-983970
(CAS: 1584713-87-0)

BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.

Methoxy-X04
(CAS: 863918-78-9)

Methoxy-X04, also called CHEMBL2181036, as a Fluorescent Amyloid-β (Aβ) probe, can be easily synthesized with carbon-11 (11C), it can detect and quantify plaque...

CAS 208255-80-5 DAPT

DAPT
(CAS: 208255-80-5)

DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human prima...

CAS 131602-53-4 Amyloid beta-peptide(25-35)

Amyloid beta-peptide(25-35)
(CAS: 131602-53-4)

Amyloid beta-peptide(25-35), the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, is functionally required for the neurotrophic and neurotoxic effects a...

CAS 313967-18-9 FLI-06

FLI-06
(CAS: 313967-18-9)

FLI-06 , a Notch inhibitor that disrupts Notch trafficking and processing, disrupts the Golgi by mechanisms different from BFA or GCA. It Reduces amyloid β secr...

FPS-ZM1
(CAS: 945714-67-0)

FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. It ...

CAS 867021-83-8 Colivelin

Colivelin
(CAS: 867021-83-8)

Colivelin, as a neuroprotective peptide and activator of STAT3 it is able to suppresses neuronal death. It is also able to protect neurons against the neurotoxi...

CAS 26130-02-9 Frentizole

Frentizole
(CAS: 26130-02-9)

Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly impr...

CAS 293762-45-5 Ro 90-7501

Ro 90-7501
(CAS: 293762-45-5)

Ro 90-7501, under the IUPCAS name 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine, a type of aminoquinolines, is an inhibitor of Aβ42 fibril ...

CAS 145915-60-2 CGP 53353

CGP 53353
(CAS: 145915-60-2)

CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibr...

CRANAD 2
(CAS: 1193447-34-5)

CRANAD 2, a difluoroboron-derivatized curcumins, is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. It penetrates the blood-brain barrier and shows...

CAS 481-53-8 Tangeretin

Tangeretin
(CAS: 481-53-8)

Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and a...

Hoechst 34580 tetrahydrochloride

A cell-permeable fluorescent dye for staining DNA and nuclei

CAS 185351-19-3 NQTrp

NQTrp
(CAS: 185351-19-3)

NQTrp, also called 1,4-Naphthoquinon-2-yl-L-tryptophan, inhibits amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from A...

LY-900009
(CAS: 209984-68-9)

LY-900009 is a small molecule inhibitor of Notch signalling with IC50 value of 0.27 nM via selective inhibition of the γ-secretase protein. LY-900009 was develo...

Chemical Structure

CAS 313967-18-9 FLI-06

Quick Inquiry

Verification code

Featured Items