FK 3311 - CAS 116686-15-8
Catalog number: 116686-15-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C15H13F2NO4S
Molecular Weight:
341.33
COA:
Inquire
Targets:
Cox-2 | COX
Description:
A selective COX-2 inhibitor
Brife Description:
A selective COX-2 inhibitor
Appearance:
Solid powder
Synonyms:
FK-3311; FK3311
Solubility:
100 mM in DMSO ; 50 mM in ethanol
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Boiling Point:
431.27° C at 760 mmHg (Predicted)
Melting Point:
183.97° C (Predicted)
InChIKey:
DIIYLGZNZGPXRR-UHFFFAOYSA-N
InChI:
1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
Canonical SMILES:
CC(=O)C1=CC(=C(C=C1)NS(=O)(=O)C)OC2=C(C=C(C=C2)F)F
1.The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs.
Takeyoshi I;Sunose Y;Iwazaki S;Tsutsumi H;Aiba M;Kasahara M;Ohwada S;Matsumoto K;Morishita Y J Surg Res. 2001 Sep;100(1):25-31.
BACKGROUND: ;Pringle's procedure is commonly used during liver surgery, and it sometimes causes liver failure. Metabolites of arachidonic acid, which are converted by cyclooxygenase (Cox), are involved in ischemia-reperfusion injury. This study evaluated the effects of FK 3311, which selectively inhibits Cox-2, on ischemia-reperfusion injury during liver resection in dogs.;MATERIALS AND METHODS: ;The animals were divided into four groups and subjected to 60 min of warm ischemia by partial inflow occlusion. The FK-treated groups (FK0.2: 0.2 mg/kg, FK1: 1 mg/kg, FK3: 3mg/kg) received FK3311, and the control group received vehicle. Following reperfusion, the nonischemic lobes were resected and remnant liver function was evaluated.;RESULTS: ;Tissue blood flow and serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase were significantly better in the FK1 and FK3 groups, especially FK1, than in the control group. Thromboxane B(2) was significantly lower in the FK1 and FK3 groups than in the control group. The level of 6-keto-prostaglandin F(1alpha) was significantly lower in the FK3 group and relatively unchanged in the FK1 group. Histological damage was milder in the FK1 group.
2.The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model.
Sunose Y;Takeyoshi I;Ohwada S;Tsutsumi H;Iwazaki S;Kawata K;Kawashima Y;Tomizawa N;Matsumoto K;Morishita Y J Am Coll Surg. 2001 Jan;192(1):54-62.
BACKGROUND: ;Liver grafts from non-heart-beating donors inevitably suffer from warm ischemic injury. In these grafts, large quantities of inflammatory cytokines and arachidonic acid metabolites are induced, further aggravating injury. Cyclooxygenase (COX) is an intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2. COX has two isoforms: constitutive COX-1 and inducible COX-2. The aim of this study was to evaluate the effects of COX-2 inhibition by FK3311 (FK) on warm ischemic injury in a canine total hepatic vascular exclusion (THVE) model.;STUDY DESIGN: ;Sixteen mongrel adult dogs were studied. The portal triad of the hilum and the inferior vena cava above and below the liver was clamped for 1 hour. Splanchnic decompression was achieved by active splenofemorojugular bypass. The animals were divided into two groups. FK (1 mg/kg) was administered in the FK group (n = 8), and saline was administered in the control group (n = 8). Hepatic venous blood was collected to measure serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), and hyaluronic acid levels. Serum thromboxane (Tx)B2 and 6-keto-PGF1alpha levels were also measured.
3.[Stereoselective synthesis and pharmacological properties of metabolites of new antiinflammatory agent. 4'-Acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311)].
Nakamura K;Ochi T;Matsuo M Yakugaku Zasshi. 1995 Nov;115(11):928-36.
Asymmetric reduction of acetophenone (FK3311: 1) and ethyl phenylglyoxylate (7) with various chiral reducing agents was investigated in an attempt to synthesize both optical isomers of the two metabolites (2 and 5) of 1. The treatment of 1 with 3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c]-[1,3,2]- oxazaborolidine-borane complex (reductants B, C) gave chiral alcohol 2 in a high optical purity. On the other hand, reduction of 7 by B-chlorodiisopinocamphenylborane (reductants E, F) gave the best result among the tested reagents. Each isomer of 2 and 5 was examined for in vitro activity to inhibit zymosan-induced prostaglandine E2 production, adjuvant-induced arthritis for antiinflammatory activity, and acetic acid-induced writhing for analgesic activity in comparison with the racemic mixture.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cox-2 Products


CAS 64490-92-2 Tolmetin sodium dihydrate

Tolmetin sodium dihydrate
(CAS: 64490-92-2)

Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory agent for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

CAY10404
(CAS: 340267-36-9)

A potent, selective COX-2 inhibitor

CAS 62-44-2 Phenacetin

Phenacetin
(CAS: 62-44-2)

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. It is a pain-relieving and fever-reducing drug and was withdrawn from the Canadian ma...

CAS 301692-76-2 Polmacoxib

Polmacoxib
(CAS: 301692-76-2)

Polmacoxib is a first-in-class NSAID drug candidate that acts as a dual inhibitor of COX-2 and carbonic anhydrase (CA). It exhibits superior safety for cardiova...

CAS 51146-56-6 (S)-(+)-Ibuprofen

(S)-(+)-Ibuprofen
(CAS: 51146-56-6)

Be capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations; As an enantiomer of (R)-(-)-Ibuprofen, it more potently inhibits COX activi...

CAS 74711-43-6 Zaltoprofen

Zaltoprofen
(CAS: 74711-43-6)

An inhibitor of Cox-1 and Cox-2;A nonsteroidal anti-inflammatory drug

CAS 41340-25-4 Etodolac

Etodolac
(CAS: 41340-25-4)

A non-selective inhibitor of COX

CAS 482-45-1 Isoimperatorin

Isoimperatorin
(CAS: 482-45-1)

Isoimperatorin is a COX-2 inhibitor, and also inhibits cytochrome P450 (CYP) isoform 1A activity. In bone marrow-derived mast cells, isoimperatorin exhibits an ...

Chemical Structure

CAS 116686-15-8 FK 3311

Quick Inquiry

Verification code

Featured Items