FIPI - CAS 939055-18-2
Catalog number:
939055-18-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H24FN5O2
Molecular Weight:
421.47
COA:
Inquire
Targets:
Phosphodiesterase (PDE)
Description:
FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.
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Purity:
>98 %
Appearance:
Light yellow to khaki Solid
Synonyms:
5-Fluoro-2-Indolyl des-Chlorohalopemide;N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide;5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide
Solubility:
DMSO: ≤ 14.67 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Density:
1.349±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
LHABRXRGDLASIH-UHFFFAOYSA-N
InChI:
InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
Canonical SMILES:
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 939055-18-2 FIPI

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