FIIN-2 - CAS 1633044-56-0
Catalog number: 1633044-56-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C35H38N8O4
Molecular Weight:
634.73
COA:
Inquire
Targets:
FGFR
Description:
FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
FIIN2; FIIN 2; FIIN-2.
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
Canonical SMILES:
O=C(NC1=CC=C(C=C1)CN2C(N(CC3=CN=C(N=C32)NC4=CC=C(C=C4)N5CCN(CC5)C)C6=CC(OC)=CC(OC)=C6)=O)C=C
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