|Description||FGIN-1-43 is a potent and specific ligand for the mitochondial DBI receptor (MDR).|
|Brife Description||MDR ligand|
(S)-(-)-4-Amino-2-hydroxybutyric acid is an analogue of γ-aminobutyric acid (GABA) that exhibits potential inhibitory activity on GABA binding and uptake by bra...
Pagoclone, an active (+)-enantiomer of the racemate RP 59037, is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and an...
Guvacine hydrochloride is a specific GABA uptake inhibitor (IC50 = 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). Guvacine may be...
CL 218872 has been found to be a benzodiazepine agonist and has been found to exhibit anxiolytic and anticonvulsant activities.
DPNI-caged-GABA, a kind of neurotransmitter, has been found to be allowed optical control of neural tissue with high spatial and temporal precision.
Ro 19-4603 is a novel potent partial inverse agonist of benzodiazepine (BZ) receptors. Ro19-4603 binds with high affinity to both diazepam-sensitive (DS) and di...
DMCM hydrochloride is a benzodiazepine inverse agonist exhibiting anxiogenic and potent convulsant activity.
CGS 20625 is a partial agonist for the benzodiazepine binding site of the GABAA receptor used as an anti-anxiety drug. It acts as a central benzodiazepine recep...
Etomidate hydrochloride is a GABAA receptor agonist used for the induction of general anaesthesia.
PHP 501 trifluoroacetate
PHP 501 trifluoroacetate is potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells), with...
Saclofen is a selective antagonist at GABAB receptors.
Afloqualone is a agonist of GABA receptor has sedative and muscle-relaxant effects.
Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.
L-655,708, an inverse agonist of α5 subunit involved in GABAA receptor, has been found to exhibit cognitive performance improvement in biological studies.
SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibit...
FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 i...
SL 651498 is a GABAA agonist selectively for subtype α2, and has the potential for the treatment of anxiety.
ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors....
Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. It acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.