FGIN-1-43 - CAS 145040-29-5
Category: Inhibitor
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Molecular Formula:
C28H36Cl2N2O
Molecular Weight:
487.51
COA:
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Targets:
GABA Receptor
Description:
FGIN-1-43 is a potent and specific ligand for the mitochondial DBI receptor (MDR).
Brife Description:
MDR ligand
Purity:
≥98%
Synonyms:
N,N-Dihexyl-2-(4-chlorophenyl)-5-chloroindole-3-acetamide; 2-[5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide
MSDS:
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InChIKey:
XTZUPNNVXIMWAR-UHFFFAOYSA-N
InChI:
InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
Canonical SMILES:
CCCCCCN(CCCCCC)C(=O)CC1=C(NC2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)Cl
1.Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43.
Guillon J;Boulouard M;Lelong V;Dallemagne P;Rault S;Jarry C J Pharm Pharmacol. 2001 Nov;53(11):1561-8.
The 2-aryl-3-indoleacetamides FGIN-1-27 and FGIN-1-43 have already been characterized in-vitro as potent and specific ligands for the mitochondrial DBI receptor. This affinity was associated with psychotropic properties in several rodent behavioural tasks (in particular anxiolytic action) via enhancement of GABA transmission through neurosteroid production. The synthesis of new 3-aryl-3-pyrrol-1-ylpropanamides 1a-i, analogues of FGIN-1-27 and FGIN-1-43, is described in four steps starting from the corresponding arylaldehydes. Preliminary evaluation of these compounds in behavioural studies (spontaneous locomotor activity and anxiolytic activity) in mice was also undertaken.
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CAS 145040-29-5 FGIN-1-43

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