Fesoterodine Fumarate - CAS 286930-03-8
Catalog number: 286930-03-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H37NO3.C4H4O4
Molecular Weight:
527.65
COA:
Inquire
Targets:
mAChR
Description:
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
Purity:
>98%
Synonyms:
SPM 907
MSDS:
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InChIKey:
MWHXMIASLKXGBU-RNCYCKTQSA-N
InChI:
InChI=1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1
Canonical SMILES:
CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(=CC(=O)O)C(=O)O
1.Oral pharmacotherapy for overactive bladder in older patients: mirabegron as a potential alternative to antimuscarinics.
Wagg A1, Nitti VW2, Kelleher C3, Castro-Diaz D4, Siddiqui E5, Berner T6. Curr Med Res Opin. 2016 Apr;32(4):621-38. doi: 10.1185/03007995.2016.1149806. Epub 2016 Feb 17.
Objective Overactive bladder (OAB) is a particular challenge to treat in older adults with co-morbid conditions taking multiple medications. Antimuscarinics (e.g., solifenacin, fesoterodine) and β3-adrenergic receptor agonists (mirabegron) are similarly efficacious; however, antimuscarinics may be associated with side effects that result in poor persistence and contribute to anticholinergic burden, particularly in those taking other medications with anticholinergic properties. With a mechanism of action distinct from antimuscarinics, mirabegron has a different tolerability profile and does not contribute to anticholinergic burden. The objective of this review was to compare and contrast the tolerability profiles of antimuscarinics and mirabegron in older patients to inform practice. Methods Prospective trials or retrospective subgroup analyses of antimuscarinics for the treatment of OAB in older patients were identified through a search of PubMed.
2.Cost effectiveness analysis of fesoterodine compared to mirabegron in first-line therapy setting for overactive bladder with urge urinary incontinence, from the Spanish National Health System perspective.
Angulo JC1, Sánchez-Ballester F2, Peral C3, Rejas J3, Ramos J3, Snedecor SJ4, Sudharshan L4, Liu S4, Luo X5. Actas Urol Esp. 2016 Mar 14. pii: S0210-4806(16)00045-0. doi: 10.1016/j.acuro.2015.11.012. [Epub ahead of print]
OBJECTIVES: To evaluate the cost-effectiveness of first-line treatment of Overactive Bladder (OAB) with fesoterodine relative to mirabegron, from the Spanish National Health System (NHS) perspective.
3.Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine.
Weissbart SJ1, Lewis R2, Smith AL3, Harvie HS4, Miller JM5, Arya LA4. J Urol. 2015 Dec 10. pii: S0022-5347(15)05396-3. doi: 10.1016/j.juro.2015.12.024. [Epub ahead of print]
PURPOSE: We investigated the long-term relationships between dry mouth, fluid intake and overactive bladder symptoms in women undergoing treatment with fesoterodine. We hypothesized that women who experienced dry mouth would increase their fluid intake and worsen their urinary symptoms.
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CAS 286930-03-8 Fesoterodine Fumarate

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