Ferulic acid sodium - CAS 24276-84-4
Catalog number: 24276-84-4
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Molecular Formula:
C10H9NaO4
Molecular Weight:
216.17
COA:
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Chemical Family:
Phenylpropanoids
Description:
Ferulic acid sodium is one of the most abundant phenolic acids ubiquitously existing in plants. Free ferulic acid is a good antioxidant since it forms a resonancestabilized phenoxy radical. Ferulic acid showed high scavenging activity for hydrogen peroxid
Purity:
>98%
Appearance:
Solid powder
Synonyms:
sodium;(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
4-hydroxy-3-methoxycinnamic acid
8,8'-diferulic acid
ferulic acid
ferulic acid, (E)-isomer
ferulic acid, (Z)-isomer
ferulic acid, monosodium salt
sodium ferulate
Solubility:
Soluble to 15mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -109℃ for long term (months to years).
MSDS:
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Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Grams-Kilos
InChIKey:
NCTHNHPAQAVBEB-WGCWOXMQSA-M
InChI:
1S/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+;
Canonical SMILES:
COC1=C(C=CC(=C1)C=CC(=O)[O-])O.[Na+]
1. Sodium Ferulate Reduces Portal Pressure Through Inhibition of RhoA/Rho-Kinase and Activation of Endothelial Nitric Oxide Synthase in Cirrhotic Rats
Jiqiao Liu • Liping Peng • Juan Yang • Min Wang • Shengnan Xu • Jingmei Liu. Dig Dis Sci (2015) 60:2019–2029
Sodium ferulate is the main constituent of Chinese angelica and szechwan lovage rhizome. Because of its multiple functions in antiplatelet aggregation, anti-inflammation, and antioxidation, SF has been wildly applied in clinical use such as for angiocardiopathy and carcinomas. In addition, SF has a negative effect on cholesterol synthesis,which probably leads to the reduction of geranylgeranyl-pyrophosphate (GGPP), a key material in activating the RhoA/Rho-kinase signaling pathway.
2. The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice
Xiaopei Yuan, Yuyun Wang, Dunren Du. Inflammation, Vol. 35, No. 3, June 2012
Sodium ferulate (SF), a compound extracted from Radix Angelicae sinensis, had been used to treat cardiovascular and cerebrovascular diseases because of its effects on anti-oxidation and anti-inflammation. Oxymatrine (OMT), the chief active component of Chinese herb Radix Sophora flavescens Ait, had been reported with the following pharmacological effects, anti-inflammation, inhibiting immune reaction, protecting hepatocytes, and anti-apoptotic. However, the single drug treatment had a weak anti-inflammatory and analgesic potency. For example, the effective dose of OMT on anti-inflammatory effect was about 100 mg/kg in the animal models. According to prescription of traditional Chinese medicine, we found that the combination of SF and OMT had obvious anti-inflammatory and analgesic effects. The main anti-inflammatory effect was on the acute phase of inflammatory infiltrates. Therefore, we speculated that the combination should be a potential effective drug to treat ALI.
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CAS 24276-84-4 Ferulic acid sodium

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