Fentrazamide - CAS 158237-07-1
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Fentrazamide, an oxotetrazole derivative, has been found to be a kind of herbicide and could be commonly used in paddy fields.
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Fentrazamide; CHEBI:81791; 4-(2-Chlorophenyl)-N-cyclohexyl-N-ethyl-4,5-dihydro-5-oxo-1H-tetrazole-1-carboxamide; Innova
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
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In-house standard
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1.Degradation of fentrazamide herbicide in soil under aerobic condition.
Tandon S1, Pujari A, Sand NK. Bull Environ Contam Toxicol. 2012 Aug;89(2):312-5. doi: 10.1007/s00128-012-0697-5. Epub 2012 Jun 12.
Dissipation of fentrazamide in soil under aerobic conditions was studied. Fentrazamide was extracted with 0.1 N HCl: acetone (1:1 v/v) followed by partition and cleanup. Separation was done on ODS-II column with mobile phase acetonitrile: water (70:30 v/v). Recovery varied from 74.51 % to 90.10 % percent in soil. Dissipation followed first order kinetics with monophasic pattern. Half life in soil was 9.02 days. Calibration curves were linear over the range of 0.05-1.00 μg mL(-1) and RSD was 1.82 %. LOD and LOQ were 0.002 and 0.005 μg g(-1) for soil. No residues in soil and crop were observed at harvest.
2.Dissipation studies of fentrazamide (YRC-2388) in soil under anaerobic condition.
Tandon S1, Pujari A, Sand NK. J Environ Monit. 2012 Sep;14(9):2521-6. doi: 10.1039/c2em30257h. Epub 2012 Aug 10.
Dissipation of fentrazamide in soil and water under flooded (anaerobic) conditions was studied. Fentrazamide was applied to soil at 100 g ha(-1). Soil was extracted with 0.1 N HCl : acetone (1 : 1 v/v) followed by partition and cleanup with silica SPE. Separation was achieved in an ODS-II column with a mobile phase of acetonitrile : water (70 : 30 v/v) and detection at 214 nm. Recovery of fentrazamide varied from 75.2-90.4% and 89.9-97.8% in soil and water, respectively. Fentrazamide dissipated rapidly and fentrazamide residues were not detected after 100 and 35 days of application in soil and water, respectively. Half life in soil and water was 9.06 and 3.66 days, respectively. Dissipation followed monophasic first order kinetics pattern. No fentrazamide was detected in soil, rice grain and rice straw at harvest of crop. Calibration curves for quantification were linear and relative standard deviation (RSD) was 1.78%. LOD for instrument was 0.
3.Effects of the new herbicide fentrazamide on the glucose utilization in neurons and erythrocytes in vitro.
Schmuck G1, Freyberger A, Ahr HJ, Stahl B, Kayser M. Neurotoxicology. 2003 Jan;24(1):55-64.
Treatment of rats with fentrazamide for 2 years at 3000 ppm (males) and 4000 ppm (females) led to an increased incidence and degree of axonal degeneration in sciatic nerve as well as to effects on red blood cells. The mechanism underlying these effects was investigated in vitro using various cell cultures (permanent rodent cell lines from the nervous system, liver, kidney, skeletal and heart muscle and fibroblasts, primary cortical neurons and erythrocytes from the rat). Added to cultured rat cortical neurons for 1 week, fentrazamide considerably decreased glucose consumption, ATP levels and mitochondrial membrane potential and lowered the GSH level, however, it had little impact on viability and neurofilaments and did not induce oxidative stress (ROS) over the first 2 h. After recovery for 1 week, in addition some destruction of neurofilaments had occurred probably secondary to the disturbance of energy production. These effects were prevented by pyruvate.
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CAS 158237-07-1 Fentrazamide

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