Fenticonazole Nitrate - CAS 73151-29-8
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Not Intended for Therapeutic Use. For research use only.
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Fenticonazole Nitrate is an azole antifungal agent.
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1.[Evaluation of the time response of a single dose administration of fenticonazole nitrate].
Balaïsch J. Contracept Fertil Sex. 1996 May;24(5):417-22.
174 women with vaginal candidosis confirmed by direct microscopic examination were treated with a single intravaginal fenticonazole nitrate capsule. One third received a second intravaginal capsule three days later. Fenticonazole nitrate cream was also applied daily on the vulvar area in 94.2% of cases. Efficacy was excellent. After one week improvement and complete healing rates were 88% and 80%, respectively. On the second day of treatment pruritus and burning abated in 78% and 85% of women. Mycologic cure demonstrated by microscopic examination was obtained in 92% of cases. Treatment acceptance and tolerance were rated good or excellent by 98% and 92% of patients. Absence of abnormal vaginal discharge due to vaginal capsule was considered as an advantage by women. Results of this trial performed on a large number of patients confirm that product efficacy is fast.
2.Toxicological and pharmacological properties of fenticonazole, a new topical antimycotic.
Graziani G, Cazzulani P, Barbadoro E. Arzneimittelforschung. 1981;31(12):2145-51.
The acute oral and subchronic (6 weeks) topical toxicity of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) was studied in mice, rats, guinea pigs and beagle dogs. The acute oral LD50 in mice and rats was found to be 3000 mg/kg, while the i.p. acute toxicity was 1191 mg/kg in mice and between 309 and 440 mg/kg in rats. The acute oral LD50 in beagle dogs was 1000 mg/kg. Percutaneous subchronic (6 weeks) toxicity was evaluated in guinea pigs and beagle dogs. Both species of animals exhibited no toxic effect attributable to the treatment with fenticonazole and no histopathologic changes were attributed to the drug treatment. Fenticonazole did not affect numerous pharmacological and physiological parameters (blood pressure, heart rate, pulmonary ventilation, nor did it interfere with the activity of histamine, adrenaline, noradrenaline and acetylcholine). It does not possess analgesic or antiinflammatory activity at high doses (100 mg/kg p.
3.Systemic absorption of 3H-fenticonazole after vaginal administration of 1 gram in patients.
Novelli A1, Periti E, Massi GB, Masi R, Mazzei T, Periti P. J Chemother. 1991 Feb;3(1):23-7.
Fourteen women, five with normal cervicovaginal mucosa (Group 1), five with cervical carcinoma (Group 2) and four with relapsing vulvovaginal candidiasis (Group 3) were enrolled and completed this open clinical trial. Each subject received a single dose of 1.82 +/- 0.3 g on average of vaginal paste (for ovules) containing about 1000 mg of 3H-fenticonazole nitrate (266 microCi). Twelve hours after vaginal administration, the paste was removed by vaginal washing. Blood, urine and stool samples were collected at specified time intervals for five days. Plasma, urine, stools and all used material in contact with the paste were assayed for radioactivity. No measurable levels of radioactivity were detected in plasma of subjects of Groups 1 and 3 while in 4 of the 5 subjects with cervical carcinoma (Group 2) fenticonazole was detected during the 24 h after administration with a peak level at about 8 hours. For a period of 5 days, 0.4-1.5% of the dose on average was recovered from urine, and 0.
4.[Efficacy and tolerance of 200 mg of fenticonazole versus 400 mg of miconazole in the intravaginal treatment of mycotic vulvovaginitis].
Muñoz Reyes JR1, Villanueva Reynoso C, Ramos CJ, Menéndez Vázquez J, Bailón Uriza R, Vargas AJ. Ginecol Obstet Mex. 2002 Feb;70:59-65.
OBJECTIVE: Fenticonazole is an imidazole derivative with a broad-spectrum antifungal activity mainly against Candida albicans. Fenticonazole nitrate was compared to myconazole vs. test efficacy, tolerance and treatment compliance in-patients with mycotic vulvovaginitis.
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CAS 73151-29-8 Fenticonazole Nitrate

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